Innovations in Airway Surgery

Manning, Amy; Wehrmann, Daniel; Hart, Catherine K.; Green, Glenn E.

doi:10.1016/j.otc.2019.06.005

Cited by 7 publications

(11 citation statements)

References 62 publications

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“…Advancements in biomaterials and new technologies have allowed for many novel stent concepts to grab news headlines, but less data are available on which of these technologies are mature enough for preclinical or clinical use (and to overcome the necessary sterilization and regulatory hurdles for use). To date, the largest body of literature in tracheal stent advancements is found in the pediatric otolaryngology literature, many of which are focused or systematic reviews of a particular type of stent material 78–80 . Applications in adults, though, can be quite different secondary to varying pathophysiology of disease processes and compromised wound healing from a number of chronic medical conditions.…”

Section: Discussionmentioning

confidence: 99%

“…To date, the largest body of literature in tracheal stent advancements is found in the pediatric otolaryngology literature, many of which are focused or systematic reviews of a particular type of stent material. [78][79][80] Applications in adults, though, can be quite different secondary to varying pathophysiology of disease processes and compromised wound healing from a number of chronic medical conditions.…”

Section: Discussionmentioning

confidence: 99%

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State of the Science in Tracheal Stents: A Scoping Review

et al. 2021

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Objective: Recent material science advancements are driving tracheal stent innovation. We sought to assess the state of the science regarding materials and preclinical/clinical outcomes for tracheal stents in adults with benign tracheal disease.Methods: A comprehensive literature search in April 2021 identified 556 articles related to tracheal stents. One-hundred and twenty-eight full-text articles were reviewed and 58 were included in the final analysis. Datapoints examined were stent materials, clinical applications and outcomes, and preclinical findings, including emerging technologies.Results: In the 58 included studies, stent materials were metals (n = 28), polymers (n = 19), coated stents (n = 19), and drug-eluting (n = 5). Metals included nitinol, steel, magnesium alloys, and elgiloy. Studies utilized 10 different polymers, the most popular included polydioxanone, poly-L-lactic acid, poly(D,L-lactide-co-glycolide), and polycaprolactone. Coated stents employed a metal or polymer framework and were coated with polyurethane, silicone, polytetrafluoroethylene, or polyester, with some polymer coatings designed specifically for drug elution. Drug-eluting stents utilized mitomycin C, arsenic trioxide, paclitaxel, rapamycin, and doxycycline. Of the 58 studies, 18 were human and 40 were animal studies (leporine = 21, canine = 9, swine = 4, rat = 3, ovine/feline/murine = 1). Noted complications included granulation tissue and/or stenosis, stent migration, death, infection, and fragmentation.Conclusion: An increasing diversity of materials and coatings are employed for tracheal stents, growing more pronounced over the past decade. Though most studies are still preclinical, awareness of tracheal stent developments is important in contextualizing novel stent concepts and clinical trials.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

State of the Science in Tracheal Stents: A Scoping Review

et al. 2021

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“…This is done by transecting at the midpoint of the stenosis, and posterior longitudinal incisions are made to widen the trachea before the anastomosis is performed [2]. Newer techniques using 3 D printed and stem cell-based tracheal transplants are being attempted [11,12].…”

Section: Discussionmentioning

confidence: 99%

Tracheal Stenosis and Congenital Heart Disease in Trisomy 21

Kylat

2019

Children

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Tracheal rings (TR) are rare, congenital cartilaginous defect of the upper airway and are usually due to complete or near complete circumferential cartilaginous tracheal rings, with variable degrees of tracheal stenosis (TS) and shortening. Chromosomal anomalies like trisomy 21 are characteristically associated with a wide range of upper airway anomalies including TS and congenital heart disease (CHD). However, the overall prevalence of severe forms of TS is rare and reported in 1.2% of all CHD patients. Herein, we present a rare association of severe TS due to complete tracheal rings in a trisomy 21 patient with CHD and the challenges in the management.

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“…The practice of complex pediatric otolaryngology will continue to evolve over the next 50 years. Exciting refinements in minimal invasive surgical techniques, such as increased application of endoscopic interventions for complex laryngeal pathologies, integration of robotic surgery both for pharyngeal and upper airway lesions, perinatal and fetal airway surgical interventions, and robotic assistance in minimalistic cochlear implant surgery—to name a few—have all been described in the recent past and will continue to expand into the future. Moreover, research in the area of 3D tissue printing and bioengineering is likely to open a whole new arena of pediatric airway surgical reconstruction .…”

Section: Futurementioning

confidence: 99%

A current render of pediatric otolaryngology in the United States

Preciado

2019

Pediatric Investigation

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Innovations in Airway Surgery

Cited by 7 publications

References 62 publications

State of the Science in Tracheal Stents: A Scoping Review

State of the Science in Tracheal Stents: A Scoping Review

Tracheal Stenosis and Congenital Heart Disease in Trisomy 21

A current render of pediatric otolaryngology in the United States

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