Innominate Grooves in the Surface of Mucosa

Williams, Ifor

doi:10.1148/84.5.877

Cited by 28 publications

(11 citation statements)

References 2 publications

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“…Spiculations have been reported to occur to a varying extent in as many as one-quarter of barium enema examinations, depending on the degree of distention of the bowel, the density of the barium mixture, and the technical quality of the radiographs [1]. In our experience, the pattern can be identified in no more than 5 10% of cases.…”

Section: Radiographic Featuresmentioning

confidence: 59%

“…However, Williams suggests that the pattern is due to barium in the pits formed at the intersection of the grooves [1]. The distance between the innomihate grooves conforms with the spacing that occurs between spiculations.…”

Section: Cause Of Pseudoulceration Patternmentioning

confidence: 70%

“…However, it may be that not all of the crypts fill with barium, but perhaps barium enters only crypts with wide orifices or those in which the lumen is not occluded with mucus. It is possible that a lace-like mucosal pattern which has been described by Williams [1] represents the innominate grooves. while the spiculated and punctate configurations corresponds to filling of the crypts of Lieberkuhn.…”

Section: Cause Of Pseudoulceration Patternmentioning

confidence: 99%

“…The crypts of Lieberkuhn or intestinal glands are straight tubules of epithelium perpendicularly orientated to the surface of the colonic mucosa. These are 0.5 7 mm in depth and are distributed uniformly throughout the colon spaced approximately 8 mm apart [1].…”

Section: Cause Of Pseudoulceration Patternmentioning

confidence: 99%

“…Williams reported that the spiculations noted on barium enema examination are not due to filling of the crypts of Lieberkuhn with barium, but instead are due to barium in the innominate grooves which are present on the surface of the colonic mucosa [1]. These grooves can be identified on gross specimens of the colon as a network of shallow channels, 0.5 to 2 mm apart, orientated circumferentially and occasionally longitudinally [3].…”

Section: Cause Of Pseudoulceration Patternmentioning

confidence: 99%

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Pseudoulcerations of the colon on barium enema examination

Frank

Berk

Goldstein

1977

Gastrointest Radiol

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Marginal spiculations and punctate collection of barium may occasionally be identified on barium examination in patients with a normal colon. These may be due either to filling of the crypts of Lieberkuhn with barium or retention of barium in the innominate grooves of the colon. Perhaps both combine to produce the radiographic findings. This normal variant must be carefully distinguished from actual ulcers associated with inflammatory bowel disease in order to avoid making a major error in diagnosis.

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Section: Radiographic Featuresmentioning

confidence: 59%

Section: Cause Of Pseudoulceration Patternmentioning

confidence: 70%

Section: Cause Of Pseudoulceration Patternmentioning

confidence: 99%

Section: Cause Of Pseudoulceration Patternmentioning

confidence: 99%

Section: Cause Of Pseudoulceration Patternmentioning

confidence: 99%

See 3 more Smart Citations

Pseudoulcerations of the colon on barium enema examination

Frank

Berk

Goldstein

1977

Gastrointest Radiol

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Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma

Filipe¹,

Branfoot²

1974

Cancer

233

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Our previous studies have shown that histologically normal mucosa adjacent to carcinomas of the large intestine is often abnormal histochemically. This „transitional”︁ mucosa, as we termed it, is characterized by an increase of sialomucins, accompanied usually by a decrease or absence of the sulphomucins which are predominant in the normal mucosa of the large intestine. The extent and intensity of these mucin changes were not clear, and so we have mapped them by cutting strips of mucosa from the whole length of 25 surgical specimens. This work confirms that the pattern of mucus secretion is altered around carcinomas, but also shows similar changes in patches of mucosa at a distance from frank tumors. The increase in sialomucins is directly related to the extent of invasion by a carcinoma according to Dukes' classification, but not to its degree of differentiation or to its histologic pattern. It is suggested that the mucin changes may reflect a transformation to a fetal type of epithelium and indicate an early stage in carcinogenesis. The practical value of these findings in diagnosis and prognosis is discussed.

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Ultrastructure of the “transitional” mucosa adjacent to large bowel carcinoma

Riddell

Levin

1977

Cancer

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The transitional mucosa immediately adjacent to large bowel carcinoma was examined in 13 patients by scanning electron microscopy (SEM), and this was correlated with transmission electron microscopy (TEM) and light microscopy (LM). Marked abnormalities were present in this mucosa in 9/13 patients with distortion and loss of the normal architecture. Examination of adenomas showed abnormalities also to be present adjacent to the neoplastic mucosa. In all patients, the transitional mucosa was compared with two pieces of normal mucosa; in one patient, typical changes of transitional mucosa were found in this region. In the remaining patients, normal mucosa by SEM was found to consist to large deep furrows (primary crypts) as well as the crypts of Lieberkuhn (secondary crypts). The secondary crypts structure showed marked individual variation between patients but one type was present in nine patients. It is uncertain whether this is a pattern with a high incidence in the general population, or whether patients with this type of mucosa are particularly predisposed to large bowel carcinoma. SEM may, therefore, play a part in identifying patients particularly likely to develop large bowel carcinoma.

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Innominate Grooves in the Surface of Mucosa

Cited by 28 publications

References 2 publications

Pseudoulcerations of the colon on barium enema examination

Pseudoulcerations of the colon on barium enema examination

Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma

Ultrastructure of the “transitional” mucosa adjacent to large bowel carcinoma

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