Inner Ear Fluid Volumes and the Resolving Power of Magnetic Resonance Imaging: Can it Differentiate Endolymphatic Structures?

Buckingham, Richard A.; Valvassori, Galdino E.

doi:10.1177/000348940111000204

Cited by 47 publications

(31 citation statements)

References 12 publications

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“…Buckingham and Valvassori [60] estimated the average total inner ear fluid volume of the bony labyrinth from histological cross-sections to be 193 mm 3 . Average inner ear fluid volumes have been measured by MR volumetric assessments in 29 healthy subjects [61] at 195 mm 3 (range 150-279 mm 3 ).…”

Section: Discussionmentioning

confidence: 99%

MR volumetric assessment of endolymphatic hydrops

Gürkov¹,

Berman²,

Dietrich³

et al. 2014

Eur Radiol

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• Endolymphatic hydrops is the pathological hallmark of Menière's disease. • Endolymphatic hydrops can be visualized by locally enhanced ultra-high-resolution MR imaging. • Computer-aided image processing enables quantification of endolymphatic hydrops. • Endolymphatic hydrops correlates with hearing loss in patients with Menière's disease. • Therapeutic trials in Menière's disease can be monitored with this quantitative approach.

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Section: Discussionmentioning

confidence: 99%

MR volumetric assessment of endolymphatic hydrops

Gürkov¹,

Berman²,

Dietrich³

et al. 2014

Eur Radiol

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“…The sum of the area of the endolymphatic duct and sac was multiplied by the section thickness, 0.8 mm. The normal volume of endolymph is about 34.0 mm 3 (17). This method has previously been described in detail (18).…”

Section: Audiological Findings and Endolymphatic Duct And Sac Volumesmentioning

confidence: 99%

Phenotypes associated with replacement of His by Arg in the Pendred syndrome gene

Sato¹,

Nakashima²,

Miura³

et al. 2001

European Journal of Endocrinology

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Background: Pendred syndrome is often associated with inner ear malformations, especially enlarged vestibular aqueduct (EVA). Recently, mutations in the Pendred syndrome gene (PDS) have been reported in patients with EVA, in addition to those with classical Pendred syndrome. Objective: The aim of this study was to investigate the genotype-phenotype correlations of PDS. Methods: Each of the 21 exons and flanking splice regions of PDS was analysed by direct DNA sequencing in nine patients with EVA; allele-specific amplification was performed to confirm the mutation. Genetic analyses were compared with thyroid function tests, perchlorate discharge tests, thyroid volume and pure-tone audiogram. Magnetic resonance imaging was used to determine the volume of the endolymphatic duct and sac of each patient. Results: A missense mutation, H723R, was identified in the homozygous state in three patients and in the heterozygous state in another three. Although none of the patients had goitre, increased serum thyroglobulin and an abnormal degree of iodide release were correlated with the number of mutant alleles identified. However, there was no relationship between the degree of hearing loss and the number of mutant alleles. Conclusion: The present study reveals that the number of mutant alleles correlates with the degree of subclinical thyroid abnormality, but not with the degree of hearing loss in Japanese patients with the PDS missense mutation H723R.

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“…Most of the functionally important elements of the cochlea are bathed in perilymph, an extracellular fluid similar to, and in diffusional contact with, the cerebrospinal fluid. Perilymph volume in the guinea pig is 15 μl [23], while that in the human is 160 μl [24]. Toward the goal of developing a chronic inner ear perfusion device for use in humans, a reciprocating microfluidic system that allows perfusion of drugs into the cochlea through a single inlet hole in scala tympani of the basal turn was developed.…”

Section: Introductionmentioning

confidence: 99%

Inner ear drug delivery via a reciprocating perfusion system in the guinea pig

Chen

Kujawa

McKenna

et al. 2005

Journal of Controlled Release

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Rapid progress in understanding the molecular mechanisms associated with cochlear and auditory nerve degenerative processes offers hope for the development of gene-transfer and molecular approaches to treat these diseases in patients. For therapies based on these discoveries to become clinically useful, it will be necessary to develop safe and reliable mechanisms for the delivery of drugs into the inner ear, bypassing the blood-labyrinthine barrier. Toward the goal of developing an inner ear perfusion device for human use, a reciprocating microfluidic system that allows perfusion of drugs into the cochlear perilymph through a single inlet hole in scala tympani of the basal turn was developed. The performance of a prototype, extracorporeal reciprocating perfusion system in guinea pigs is described. Analysis of the cochlear distribution of compounds after perfusion took advantage of the place-dependent generation of responses to tones along the length of the cochlea. Perfusion with a control artificial perilymph solution had no effect. Two drugs with wellcharacterized effects on cochlear physiology, salicylate (5 mM) and DNQX (6,7-Dinitroquinoxaline-2,3-dione; 100 and 300 μM), reversibly altered responses. The magnitude of drug effect decreased with distance from the perfusion pipette for up to 10 mm, and increased with dose and length of application.

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Inner Ear Fluid Volumes and the Resolving Power of Magnetic Resonance Imaging: Can it Differentiate Endolymphatic Structures?

Cited by 47 publications

References 12 publications

MR volumetric assessment of endolymphatic hydrops

MR volumetric assessment of endolymphatic hydrops

Phenotypes associated with replacement of His by Arg in the Pendred syndrome gene

Inner ear drug delivery via a reciprocating perfusion system in the guinea pig

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