MR volumetric assessment of endolymphatic hydrops

Gürkov, Robert; Berman, Albert; Dietrich, Olaf; Flatz, Wilhem; Jerin, Claudia; Krause, Eike; Keeser, Daniel; Ertl‐Wagner, Birgit

doi:10.1007/s00330-014-3414-4

Cited by 86 publications

(61 citation statements)

References 51 publications

(45 reference statements)

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“…The use of an independent test set would provide information on the diagnostic accuracy of this method. The advantage of using machine learning in combination with radiomics is that the analysis of the labyrinth could possibly be done autonomously as automatic image segmentation and registration are already feasible (25). The scalability that results from such a setup could possibly reshape diagnostics of the inner ear in the field of (neuro)radiology.…”

Section: Discussionmentioning

confidence: 99%

An Exploratory Study to Detect Ménière’s Disease in Conventional MRI Scans Using Radiomics

et al. 2016

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ObjectiveThe purpose of this exploratory study was to investigate whether a quantitative image analysis of the labyrinth in conventional magnetic resonance imaging (MRI) scans using a radiomics approach showed differences between patients with Ménière’s disease (MD) and the control group.Materials and methodsIn this retrospective study, MRI scans of the affected labyrinths of 24 patients with MD were compared to the MRI scans of labyrinths of 29 patients with an idiopathic asymmetrical sensorineural hearing loss. The 1.5- and 3-T MRI scans had been previously made in a clinical setting between 2008 and 2015. 3D Slicer 4.4 was used to extract several substructures of the labyrinth. A quantitative analysis of the normalized radiomic image features was performed in Mathematica 10. The image features of the two groups were statistically compared.ResultsFor numerous image features, there was a statistically significant difference (p-value <0.05) between the MD group and the control group. The statistically significant differences in image features were localized in all the substructures of the labyrinth: 43 in the anterior semicircular canal, 10 in the vestibule, 22 in the cochlea, 12 in the posterior semicircular canal, 24 in the horizontal semicircular canal, 11 in the common crus, and 44 in the volume containing the reuniting duct. Furthermore, some figures contain vertical or horizontal bands (three or more statistically significant image features in the same image feature). Several bands were seen: 9 bands in the anterior semicircular canal, 1 band in the vestibule, 3 bands in the cochlea, 0 bands in the posterior semicircular canal, 5 bands in the horizontal semicircular canal, 3 bands in the common crus, and 10 bands in the volume containing the reuniting duct.ConclusionIn this exploratory study, several differences were found in image features between the MD group and the control group by using a quantitative radiomics approach on high resolution T2-weighted MRI scans of the labyrinth. Further research should be aimed at validating these results and translating them in a potential clinical diagnostic method to detect MD in MRI scans.

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Section: Discussionmentioning

confidence: 99%

An Exploratory Study to Detect Ménière’s Disease in Conventional MRI Scans Using Radiomics

et al. 2016

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“…The intratympanic application route of GBCA is being increasingly used in the diagnosis of Ménièrés disease. MRI with GBCA is an important tool, not only for diagnosis, but also in the follow‐up, and to evaluate the therapeutic results . Furthermore, important new insights into the transport mechanisms of substances across the middle ear can be gained, such as the middle ear ‐ inner ear barrier can be obtained from imaging studies after intratympanic GBCA application.…”

Section: Discussionmentioning

confidence: 99%

“…MRI with GBCA is an important tool, not only for diagnosis, but also in the follow-up, 13 and to evaluate the therapeutic results. 14,15 Furthermore, important new insights into the transport mechanisms of substances across the middle ear can be gained, such as the middle ear -inner ear barrier can be obtained from imaging studies after intratympanic GBCA application. Recently, the oval window could be identified as a major transmission route, whereas traditionally, the round window was thought to be the main entry point into the inner ear.…”

Section: Discussionmentioning

confidence: 99%

Hearing function after intratympanic application of gadolinium‐based contrast agent: A long‐term evaluation

2015

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“…The role of new imaging techniques is gaining importance in ELH diagnosis, since conventional MRI is unable to distinguish the endolymphatic from the perilymphatic compartments within the inner ear 23 . In the recent years, several efforts have been made to develop reliable imaging able to identify ELH; some inner ear imaging techniques enable visualizing morphological changes in the cochlea and the vestibulum in vivo 24 . Current research demonstrates the validity of Locally Enhanced Inner Ear MRI (LEIM) after intratympanic contrast agent application and 3-Tesla MRI performed with intravenous gadolinium with 3D-FLAIR sequences for the diagnosis and grading of ELH; these techniques have shown similar sensitivity to histopathological series in identifying ELH [25][26][27] .…”

Section: Discussionmentioning

confidence: 99%

Vestibular Schwannoma and Ipsilateral Endolymphatic Hydrops: An Unusual Association

Ralli

Greco

Altissimi

et al. 2017

The International Tinnitus Journal

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Vestibular schwannoma and endolymphatic hydrops are two conditions that may present with similar audio-vestibular symptoms. The association of the two in the same patient represents an unusual finding that may lead clinicians to errors and delays in diagnosis and clinical management of affected subjects. We discuss the case of a patient with an intrameatal vestibular schwannoma reporting symptoms suggestive for ipsilateral endolymphatic hydrops. The patient presented with fluctuating hearing loss, tinnitus, and acute rotatory vertigo episodes, and underwent a full audiological evaluation and imaging of the brain with contrast-enhanced Magnetic Resonance Imaging. Clinical audio-vestibular and radiological examination confirmed the presence of coexisting vestibular schwannoma and endolymphatic hydrops. Hydrops was treated pharmacologically; vestibular schwannoma was monitored over time with a wait and scan protocol through conventional MRI. The association of vestibular schwannoma and endolymphatic hydrops is rare, but represents a possible finding in clinical practice. It is therefore recommended investigating the presence of inner ear disorders in patients with vestibular schwannoma and, similarly, to exclude the presence of this condition in patients with symptoms typical of inner ear disorders.

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MR volumetric assessment of endolymphatic hydrops

Cited by 86 publications

References 51 publications

An Exploratory Study to Detect Ménière’s Disease in Conventional MRI Scans Using Radiomics

An Exploratory Study to Detect Ménière’s Disease in Conventional MRI Scans Using Radiomics

Hearing function after intratympanic application of gadolinium‐based contrast agent: A long‐term evaluation

Vestibular Schwannoma and Ipsilateral Endolymphatic Hydrops: An Unusual Association

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