Innate Lymphoid Cells and Intestinal Inflammatory Disorders

Zheng, Mingzhu; Zhu, Jinfang

doi:10.3390/ijms23031856

Cited by 14 publications

(10 citation statements)

References 109 publications

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“… 55 , 71 Th1 cells and ILC1s eradicate viruses, bacteria, or protozoa from the body through production of IFN-γ. 75 Th2 and ILC2 cells, which produce IL-5 and IL-13, respectively, are behind development of allergies and assist in the elimination of helminths. ILC3s and Th17 cells also contribute to autoimmunity by the secretion of IL-17 and IL-22, respectively, which provide protection against fungal and extracellular bacterial infections ( Figure 3 ).…”

Section: Methodsmentioning

confidence: 99%

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Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

et al. 2022

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The human intestine hosts diverse microbial communities that play a significant role in maintaining gut-skin homeostasis. When the relationship between gut microbiome and the immune system is impaired, subsequent effects can be triggered on the skin, potentially promoting the development of skin diseases. The mechanisms through which the gut microbiome affects skin health are still unclear. Enhancing our understanding on the connection between skin and gut microbiome is needed to find novel ways to treat human skin disorders. In this review, we systematically evaluate current data regarding microbial ecology of healthy skin and gut, diet, pre- and probiotics, and antibiotics, on gut microbiome and their effects on skin health. We discuss potential mechanisms of the gut-skin axis and the link between the gut and skin-associated diseases, such as psoriasis, atopic dermatitis, acne vulgaris, rosacea, alopecia areata, and hidradenitis suppurativa. This review will increase our understanding of the impacts of gut microbiome on skin conditions to aid in finding new medications for skin-associated diseases.

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Section: Methodsmentioning

confidence: 99%

“…ILC3s and Th17 cells also contribute to autoimmunity by the secretion of IL-17 and IL-22, respectively, which provide protection against fungal and extracellular bacterial infections ( Figure 3 ). 75 …”

Section: Methodsmentioning

confidence: 99%

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

et al. 2022

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“…Further understanding of ILC3s regulatory mechanism and the crosstalk of ILC3s and other ILC subsets, adaptive immune cells, lymphoid tissues and microbes will have a place in future inflammatory disease and tumor treatment. 4. Can all ILC conversion be reversed and how can ILC plasticity be regulated to alleviate inflammation or tumor progression?…”

Section: Discussionmentioning

confidence: 99%

“…ILC3s are crucial in response to bacterial infection in the gut, especially for Citrobacter rodentium (8,9). Once gut immune cells sense bacterial antigens, tissue-resident dendritic cells (DCs) and mononuclear cells produce numerous IL-23 and IL-1bstimulating ILC3s to produce IL-17 and IL-22 to maintain intestinal homeostasis (4,(10)(11)(12). Furthermore, commensal flora influences the functional characteristics of intestinal NKp46+ cells.…”

Section: Introductionmentioning

confidence: 99%

Controversial role of ILC3s in intestinal diseases: A novelty perspective on immunotherapy

et al. 2023

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ILC3s have been identified as crucial immune regulators that play a role in maintaining host homeostasis and modulating the antitumor response. Emerging evidence supports the idea that LTi cells play an important role in initiating lymphoid tissue development, while other ILC3s can promote host defense and orchestrate adaptive immunity, mainly through the secretion of specific cytokines and crosstalk with other immune cells or tissues. Additionally, dysregulation of ILC3-mediated overexpression of cytokines, changes in subset abundance, and conversion toward other ILC subsets are closely linked with the occurrence of tumors and inflammatory diseases. Regulation of ILC3 cytokines, ILC conversion and LTi-induced TLSs may be a novel strategy for treating tumors and intestinal or extraintestinal inflammatory diseases. Herein, we discuss the development of ILCs, the biology of ILC3s, ILC plasticity, the correlation of ILC3s and adaptive immunity, crosstalk with the intestinal microenvironment, controversial roles of ILC3s in intestinal diseases and potential applications for treatment.

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“…11,18,19 Such gut dysbiosis and intestinal barrier injury can contribute to the enrichment of ILC3s. 20,21 Furthermore, ILC3s can secrete several pro-inflammatory cytokines, including IL-17 and granulocyte-macrophage colony-stimulating factor, 22 which may promote kidney and intestine inflammation, [22][23][24] reduce UA excretion and subsequently exacerbate UA accumulation in patients with HUA. Thus, targeting ILC3s may be a novel therapeutic strategy for HUA.…”

Section: Discussionmentioning

confidence: 99%

Type 3 innate lymphoid cells as an indicator of renal dysfunction and serum uric acid in hyperuricemia

Chen¹,

Liu²,

Wang³

et al. 2022

Adv Clin Exp Med

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Background. Type 3 innate lymphoid cells (ILC3s) are a newly identified group of innate immune cells that participate in the progression of several metabolic diseases by secreting interleukin (IL)-17 and IL-22. These cytokines are associated with hyperuricemia (HUA) severity and development; however, the relationship between ILC3s and HUA remains unclear.Objectives. To determine the characteristics of circulating ILC3s in patients with HUA.Materials and methods. Type 3 innate lymphoid cells and their subsets were detected using flow cytometry in peripheral blood mononuclear cells (PBMCs) of 80 HUA patients and 30 healthy controls (HC). Plasma levels of IL-17A and IL-22 were measured with enzyme-linked immunosorbent assay (ELISA). Clinical data of enrolled subjects were collected from electronic medical records. Results.In patients with HUA, the frequency of circulating ILC3s was elevated and positively correlated with levels of serum uric acid and serum creatinine (Scr). Although there was no significant difference in the plasma concentration of IL-17A between the patients with HUA and healthy controls, positive correlations between plasma IL-17A and the concentration of serum uric acid and frequency of circulating ILC3s were observed in the patients with HUA. Conclusions.In patients with HUA, positive correlations were detected between circulating ILC3 levels, plasma IL-17A and serum uric acid. Therefore, ILC3s and IL-17A may be useful indicators of disease severity, and are potential new therapeutic targets in HUA.

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Innate Lymphoid Cells and Intestinal Inflammatory Disorders

Cited by 14 publications

References 109 publications

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

Controversial role of ILC3s in intestinal diseases: A novelty perspective on immunotherapy

Type 3 innate lymphoid cells as an indicator of renal dysfunction and serum uric acid in hyperuricemia

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