“…Asthma is a chronic inflammatory disorder of the airway that is caused by multiple factors that involve environmental, genetic, and immunologic factors. 5,6 It is now thought that asthma may not solely be controlled by the Th2 subset but that a variety of T cells and cytokines are involved in the pathogenesis of asthma. 16,17 Th2 cells have been shown to play a critical role in the pathogenesis of eosinophilic asthma by producing IL-4, IL-5, and IL-13 cytokines; whereas Th1 cells, especially Th17 cells, are mainly involved in the pathogenesis of neutrophilic asthma, and the differentiation and activation of Th17 cells require the presence of cytokines, including IL-1, IL-6, transforming growth factor  and IL-23.…”