Association between psoriasis and asthma risk: A meta-analysis

Abstract

(OR 1.35 [95% CI,) and white populations (OR 1.27 [95% CI,) with psoriasis compared with those without psoriasis. Conclusion:Results of this meta-analysis indicated that the patients with psoriasis had a higher risk of asthma susceptibility, especially among the older patients with psoriasis.

Increased risk of psoriasis in children and elderly patients with asthma: a longitudinal follow‐up study using a national sample cohort

“…In line with the present results, a few recent studies reported the association of psoriasis with asthma . However, only a retrospective cohort study investigated the high risk of psoriasis in children with asthma .…”

“…Thus, we speculated that asthma patients have an increased risk of psoriasis. When the PubMed and EMBASE databases were searched for studies using the keyword phrase “(asthma) AND (psoriasis),” several studies evaluating the increased risk of asthma in psoriasis patients were found . The psoriasis patients demonstrated a risk of asthma 1.38 times higher than that of the control group (95% confidence interval [CI], 1.23 to 0.54) .…”

Psoriasis and Respiratory Comorbidities: The Added Value of Fraction of Exhaled Nitric Oxide as a New Method to Detect, Evaluate, and Monitor Psoriatic Systemic Involvement and Therapeutic Efficacy

“…The pathophysiology is also enriched by several overlapping genetic risk loci that link psoriasis to asthma [ 66 – 68 ]. A recent meta-analysis described that asthma risk in PS patients is higher and that patients >50 years old have the highest risk [ 69 ], due to the increased duration of long-term inflammation in the airways.…”

Asthma and psoriasis: What do they have in common? IL-17A!

“…As the authors explain, they reviewed the clinical characteristics of the U-BIOPRED subjects studied, and psoriasis was not an associated finding in this small patient population. However, associations have been noted for an increased asthma risk in the presence of coexisting psoriasis 6 ; in addition, childhood asthma was associated with a significantly increased risk for psoriasis. Furthermore, the cutaneous debilitating features of psoriasis have been most dramatically responsive to anti-IL-17A mAb treatment, confirming the importance of the IL-17A pathway to the pathophysiology of psoriasis.…”

“…The importance of this pathway is noted by other investigators 3,4 who have described the biological properties of IL-17 and its potential contributions to the pathophysiology of asthma in subpopulations of patients and have identified IL-17's presence in patients with severe asthma. 5 For many of us, IL-17 is considered the prototype cytokine for non-T2 severe asthma, which is characterized by neutrophilic airway inflammation, a diminished responsiveness to corticosteroids, dysbiosis, and older age, 6 and is a potential contributing factor for the emergence of respiratory bacteria. 3 Clinical trials with biological antagonists for IL-17, including the IL-17RA antagonist brodalumab, have failed to elicit a consistent pattern of efficacy, thus questioning whether the IL-17 pathway plays a role in severe asthma.…”