Innate immunity in the malaria vectorAnopheles gambiae:comparative and functional genomics

Abstract

The resurgence of malaria is at least partly attributed to the absence of an effective vaccine, parasite resistance to antimalarial drugs and resistance to insecticides of the anopheline mosquito vectors. Novel strategies are needed to combat the disease on three fronts: protection

Correlation of Differential Expression of Silkworm Antimicrobial Peptide Genes with Different Amounts of Rel Family Proteins and Their Gene Transcriptional Activity

“…[1][2][3][4][5] Rapid production of humoral factors such as antimicrobial peptides (AMPs) in response to infectious pathogens is a common immunity reaction. 6,7) In Drosophila melanogaster, the Toll and immune deficiency (IMD) pathways are activated through recognition of invasive pathogens.…”

A genome-wide analysis of genes and gene families involved in innate immunity of Bombyx mori

“…Insects have an efficient and potent innate immune system to discriminate and eliminate invading pathogens and parasites (Engströ m, 1999;Hoffmann et al, 1999;Hultmark, 2003;Osta et al, 2004;Imler and Bulet, 2005). This system involves cellular and humoral immune reactions against microbial infections that maintain close networks with each other and occur first in the epidermis, gut and tracheal respiratory organs and then in the hemocoel.…”

Differentially expressed genes between female and male adult Anopheles anthropophagus

“…SSH has been proven useful for the identification of differentially expressed genes in parasites (Nowak and Loker 2005), and microarrays have been used in A. gambiae in the past (Biessmann et al 2005;Marinotti et al 2005;Warr et al 2007). Through these studies, the functions of many new genes and proteins were illuminated (Osta et al 2004;Calvo et al 2006;Gomez et al 2005;Dana et al 2006). Moreover, our staff explored differentially expressed genes in female Culex pipiens pallens by SSH and identified an important female-specific gene which encoded for a salivary peptide (Chen et al 2007).…”