Inlay osteotome sinus floor elevation with concentrated growth factor application and simultaneous short implant placement in severely atrophic maxilla

Chen, Yonghui; Cai, Zhiyu; Zheng, Dingguo; Lin, Pei Yang; Cai, Yanfei; Hong, Shuxin; Lai, Yiwei; Wu, Dong

doi:10.1038/srep27348

Cited by 29 publications

(25 citation statements)

References 40 publications

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“…This finding is also in agreement with those of previous investigations indicating that A‐PRF and CGF are beneficial for alveolar bone regeneration . ‒ However, there is minimal information regarding their optimal clinical application in periodontal IBDs. This study represents the first retrospective study comparing clinical effectiveness of A‐PRF and CGF, indicating which both have the potential application value as a desired GTR biomaterial by the promotion of vital bone formation at the treated BD site.…”

Section: Discussionsupporting

confidence: 92%

Quantification of growth factors in advanced platelet‐rich fibrin and concentrated growth factors and their clinical efficacy as adjunctive to the GTR procedure in periodontal intrabony defects

Lei

Han

et al. 2019

Journal of Periodontology

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Background:The development of platelet concentrated biomaterials has gained increasing awareness for regenerative medicine. With different protocol, derivatives such as advanced platelet-rich fibrin (A-PRF), injected platelet-rich fibrin, and concentrated growth factor (CGF) have been demonstrated effectively in preclinical and clinical studies. The aim of this study was to compare the level of growth factors releasing from A-PRF and CGF, and their clinical efficacy in the regenerative management of intrabony defects (IBDs).Methods: Thirty-two blood samples were collected from eight healthy donors and assessed for platelet-derived growth factor-, vascular endothelial growth factor, bone morphogenetic protein-2, and transforming growth factor-1 release at indicated times. In addition, the clinical records of 45 patients (15 per group) who had undergone guided tissue regeneration (GTR) with or without A-PRF/CGF were retrieved. The probing depth (PD) and clinical attachment level (CAL) were recorded preoperatively and 6 months postoperatively. Intrabony component (IC) depth, radiographic bone level (RBL), and bone defect filling were assessed radiographically. Results:A-PRF had a looser fibrin network than the CGF but presented larger amounts of growth factors with a more sustained release period. Although there was no difference in PD reduction, CAL gain, RBL height change and defect filling (%) between A-PRF and CGF group, both achieved a more favorable clinical result in IC height reduction and defect filling (%) than the control. Conclusions:A-PRF and CGF have the ability to stimulate a continual and steady release of total growth factors over a 14-day period. A-PRF and CGF show a similar effectiveness in periodontal bone regeneration with a potential benefit of improving GTR outcomes in IBD treatment. K E Y W O R D Sbone substitutes, growth factors, guided tissue regeneration, periodontitis, platelet-rich fibrin 462

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Section: Discussionsupporting

confidence: 92%

Quantification of growth factors in advanced platelet‐rich fibrin and concentrated growth factors and their clinical efficacy as adjunctive to the GTR procedure in periodontal intrabony defects

Lei

Han

et al. 2019

Journal of Periodontology

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“…Three different protocols were used for each volunteer (V1, V2, and V3) to produce the CGF, varying for each one the blood collection tube composition and morphology: PROTOCOL 1: sterile Vacuette tubes (Greiner Bio‐One, GmbH, Kremsmunster, Austria) coated with silica microparticles (SCTs) as a serum clot activator were used for blood collection (Borsani et al, ; Chen et al, ; Rodella et al, ) (Figure a). PROTOCOL 2: glass tubes with a round bottom (GRBTs) (Silfradent srl, Forli, Italy) were used for blood collection (Figure b) PROTOCOL 3: glass tubes with a conical bottom (GCBTs) (Silfradent srl, Forli, Italy) were used for blood collection (Figure c) …”

Section: Methodsmentioning

confidence: 99%

“…PROTOCOL 1: sterile Vacuette tubes (Greiner Bio‐One, GmbH, Kremsmunster, Austria) coated with silica microparticles (SCTs) as a serum clot activator were used for blood collection (Borsani et al, ; Chen et al, ; Rodella et al, ) (Figure a).…”

Section: Methodsmentioning

confidence: 99%

“…CGF is obtained through a specific and standardized protocol of centrifugation which requires a special programmed centrifuge (Medifuge MF200, Silfradent srl, Forli, Italy) and specific plastic tubes, coated with silica microparticles (Greiner Bio‐One, GmbH, Kremsmunster, Austria), for blood collection, without the addition of exogenous substances (Borsani et al, ; Chen et al, ; Rodella et al, ). This method allows to separate CGF in three different fractions: the upper white part (WP), the downer red part (RP), and the middle “buffy coat” (BC), interface between white and red part.…”

Section: Introductionmentioning

confidence: 99%

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How the different material and shape of the blood collection tube influences the Concentrated Growth Factors production

Bonazza

Borsani

Buffoli

et al. 2016

Microscopy Res & Technique

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Platelet concentrates, such as Concentrated Growth Factors (CGF), are autologous preparations obtained from the patient's own blood and rich in platelets, growth factors and cytokines involved in the key processes of tissue regeneration. These autologous concentrates differ in the way of preparation and also in the content of platelets, growth factors and leucocytes, as well as in the fibrin network architecture. So it is difficult to have a standardized product. The aim of the present study was to evaluate how the use of test tubes of different material, for blood collection, could influence the CGF production. Three different test tubes were used and the obtained CGFs were subjected to histomorphological and immunohistochemical analyses. Results showed that the tube material and shape influenced the CGF composition. In fact, according to the type of tube used, the obtained CGFs showed differences in morphology, in the fibrin network architecture and in blood cell localization and distribution.

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“…Honda etal 2013 7 Found that CGF promoted proliferation, osteogenic maturation and mineralization of mesenchymal stem cells in vitro more over the authors found that combining CGFs with bone marrow stroma cells resulted in excellent healing of critical sized bone defects in vivo. 8 Evaluated short term performance of implants placed after modified osteotome sinus floor elevation with CGFs in atrophic maxilla. The results showed high survival rate for these cases.…”

Section: Introductionmentioning

confidence: 99%

Boosting Effect of Concentrated Growth Factor on Osseointegration of Immediate Implant: A Histological Analysis in Dogs

Moutamed

2019

Egyptian Dental Journal

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Background: Implant osseointegration is an important of long term success of the widely used Rehabilitation treatment. Many therapeutic presidiums have been investigated to accelerate osseointegration. Concentrated growth factors are third generation platelet concentrate used clinically in acceleration of tissue healing and bone regeneration. The aim of this study was to assess histologically the effect of using CGF on osseointegration of immediate dental implant in animal model Methods: ten animal models (adult mongrel dogs) were selected in this study each to receive one immediate implant of the Spectra system (Inc. Las Vegas, NV 89149, CA. USA). They were divided in to 2 equal groups; group A received immediate implant without CGF as a control group and group B received immediate implant with CGF which was applied to the socket walls before implant placement. Eight weeks postoperatively the animal models were euthanized and implants with surrounding bone were dissected and transferred in formalin to the lab for histologic preparation and histomorphometric analysis Results: histomorphometric analysis revealed the mean percentage of new bone formation for group A (control group) was 25.662 % while for group B it reached 66.939%. Student's t -test revealed that the difference between both groups was statistically significant difference with p value of 0.0001 which indicated the higher amount of bone regeneration in group B indicative of the accelerated osseointegration process in the test group.Conclusion it may be concluded that application of CGF to the socket walls before placement of immediate implant may enhance the healing of bone surrounding implants and accelerate osseointegration providing a convenient and affordable choice for implant placement. Application of this method may, therefore, be effective in enhancing the rate of osseointegration and allow for early loading of immediate implants.

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Inlay osteotome sinus floor elevation with concentrated growth factor application and simultaneous short implant placement in severely atrophic maxilla

Cited by 29 publications

References 40 publications

Quantification of growth factors in advanced platelet‐rich fibrin and concentrated growth factors and their clinical efficacy as adjunctive to the GTR procedure in periodontal intrabony defects

Quantification of growth factors in advanced platelet‐rich fibrin and concentrated growth factors and their clinical efficacy as adjunctive to the GTR procedure in periodontal intrabony defects

How the different material and shape of the blood collection tube influences the Concentrated Growth Factors production

Boosting Effect of Concentrated Growth Factor on Osseointegration of Immediate Implant: A Histological Analysis in Dogs

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