The current situation presents a pressing need to reduce pharmacokinetic variations of drugs in cancer patients. Although most of the omics technologies are not entirely focussed on the study of pharmacokinetic variations and some studies are met with uncertainty, the use of pharmacometabolomics combined with other omics technology such as pharmacogenomics can provide clues to personalised cancer treatments by providing useful information about the cancer patient's response to medical interventions via identification of patients' dependent variables, understanding of correlations between individuals and population PKs, and therapy outcomes to achieve optimum therapeutic effects with minimum toxicity. We also propose an approach for PKs' evaluation using pharmacometabolomics.
Schneiderian membrane perforation is one of the main complications during sinus augmentation. The aim of the study was to investigate sinus membrane rupture in maxillary sinus lifting surgery with the ultrasound and with conventional rotary technique, analyzing the bone gain obtained after the operation using cone beam computed tomography (CBCT), and examining the postaugmentation survival of implants. Twenty-two patients requiring dental implant therapy in the posterior maxillary region with insufficient bone volume were included in the study. Patients were randomly and equally allocated to Piezosurgery group and the conventional rotary group. A total of 22 sinus lifting surgeries were carried out; 11 with ultrasound in piezosurgery group and 11 with DASK drills in conventional rotary group. A total of 47 dental implants were placed three months after sinus augmentation. Patients were randomly and equally allocated to Piezosurgery group and the conventional rotary group. In either Piezosurgery group or conventional group a total of 11 sinus lifting surgeries in 11 patients were performed. The bone gain obtained as a result of sinus lift was calculated using CBCT scanning. Perforations of Schneider's membrane with the ultrasound and rotary technique occurred in 9% and 18 % of the cases, respectively, with membrane integrity being preserved in 86.3% of operated patients. All 47 implants placed showed the implant success criteria throughout postoperative follow-up in the both study groups. No statically significant difference in bone gain was recorded between study groups. In conclusions, perforations of the membrane in sinus lift were more frequent with the rotary technique (18%) than with ultrasound (9%). Implant survival and bone gain were statistically showed no significant difference between the two study groups throughout follow-up period.(1322) Gamal M. Moutamed E.D.
Background: Implant osseointegration is an important of long term success of the widely used Rehabilitation treatment. Many therapeutic presidiums have been investigated to accelerate osseointegration. Concentrated growth factors are third generation platelet concentrate used clinically in acceleration of tissue healing and bone regeneration. The aim of this study was to assess histologically the effect of using CGF on osseointegration of immediate dental implant in animal model Methods: ten animal models (adult mongrel dogs) were selected in this study each to receive one immediate implant of the Spectra system (Inc. Las Vegas, NV 89149, CA. USA). They were divided in to 2 equal groups; group A received immediate implant without CGF as a control group and group B received immediate implant with CGF which was applied to the socket walls before implant placement. Eight weeks postoperatively the animal models were euthanized and implants with surrounding bone were dissected and transferred in formalin to the lab for histologic preparation and histomorphometric analysis Results: histomorphometric analysis revealed the mean percentage of new bone formation for group A (control group) was 25.662 % while for group B it reached 66.939%. Student's t -test revealed that the difference between both groups was statistically significant difference with p value of 0.0001 which indicated the higher amount of bone regeneration in group B indicative of the accelerated osseointegration process in the test group.Conclusion it may be concluded that application of CGF to the socket walls before placement of immediate implant may enhance the healing of bone surrounding implants and accelerate osseointegration providing a convenient and affordable choice for implant placement. Application of this method may, therefore, be effective in enhancing the rate of osseointegration and allow for early loading of immediate implants.
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