Injecting engineered anti-inflammatory macrophages therapeutically induces white adipose tissue browning and improves diet-induced insulin resistance

Liu, Pu Ste; Lin, Yi; Burton, Frank H.; Wei, Li‐Na

doi:10.4161/21623945.2014.981438

Cited by 36 publications

(38 citation statements)

References 21 publications

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“…Receptor Interacting Protein‐140 (RIP140) knockdown in macrophages through transgenic and bone marrow transplantation procedures under HFD induced states remarkably improved WAT browning and improved systemic insulin sensitivity in these mice (Figure ) . Results were subsequently confirmed by the same group by injecting engineered anti‐inflammatory macrophages (lacking RIP140) marking improvement in insulin sensitivity . This data hints the presence of specialised metabolic receptors on immune system cells, which ultimately primes its responses according to metabolic states outside.…”

Section: Immunometabolism In Metabolic Deregulationmentioning

confidence: 77%

“…6 Results were subsequently confirmed by the same group by injecting engineered antiinflammatory macrophages (lacking RIP140) marking improvement in insulin sensitivity. 7 This data hints the presence of specialised metabolic receptors on immune system cells, which ultimately primes its responses according to metabolic states outside. Interesting evidence in this regard is presented recently by Bekkering et al who reported that metabolic signals can induce trained immunity.…”

Section: Immunometabolism In Metabolic Dere Gulationmentioning

confidence: 96%

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Immunometabolism features of metabolic deregulation and cancer

Wang

Ping

Bakht

et al. 2018

J Cellular Molecular Medi

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Immunometabolism is a branch dealing at the interface of immune functionalities and metabolic regulations. Considered as a bidirectional trafficking, metabolic contents and their precursors bring a considerable change in immune cells signal transductions which as a result affect the metabolic organs and states as an implication. Lipid metabolic ingredients form a major chunk of daily diet and have a proven contribution in immune cells induction, which then undergo metabolic pathway shuffling inside their ownself. Lipid metabolic states activate relevant metabolic pathways inside immune cells that in turn prime appropriate responses to outside environment in various states including lipid metabolic disorders itself and cancers as an extension. Although data on Immunometabolism are still growing, but scientific community need to adjust and readjust according to recent data on given subject. This review attempts to provide current important data on Immunometabolism and consequently its metabolic ramifications. Incumbent data on various lipid metabolic deregulations like obesity, metabolic syndrome, obese asthma and atherosclerosis are analysed. Further, metabolic repercussions on cancers and its immune modalities are also analysed.

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Section: Immunometabolism In Metabolic Deregulationmentioning

confidence: 77%

Section: Immunometabolism In Metabolic Dere Gulationmentioning

confidence: 96%

Immunometabolism features of metabolic deregulation and cancer

Wang

Ping

Bakht

et al. 2018

J Cellular Molecular Medi

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“…Although the role M2 macrophages in the adipose tissue is currently unclear and has been subjected to controversies, two recent studies showed a crucial role for M2 macrophages in promoting adipose tissue beiging and metabolic function. Both used transgenic macrophages unable to switch from M2 to M1 and demonstrated an improvement of metabolic parameters upon DIO …”

Section: The Impact Of Type 2 Immunity and Adipose Tissuementioning

confidence: 99%

The interplay of type 2 immunity, helminth infection and the microbiota in regulating metabolism

2019

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Type 2 immunity has recently emerged as a critical player in metabolic status, with numerous studies investigating the role of type 2 immune cells within adipose tissue. Metabolic dysfunction is often characterised as a low‐grade or chronic inflammatory state within tissues, and type 2 immunity may facilitate a return to metabolic homeostasis. A complex network of type 2 resident cells including M2 macrophages, eosinophils and ILC2s has been identified within adipose tissue. Although the effector cells in this equilibrium have not been clearly identified, any alteration of the type 2 microenvironment resulted in an altered metabolic state. Historically, the type 2 immune response has been associated with helminth infection. The type 2 immune response drives host resistance and plays an important role in promoting tissue repair following the migration of helminth larvae through tissues. Although helminths are largely eradicated in developed countries, infection rates remain high in poor communities within the developing world. Interestingly, there is strong evidence that helminth infection is inversely correlated with autoimmune or inflammatory disorders. Recently, an increasing amount of epidemiological and field studies suggest that it could be the same for obesity and metabolic syndrome. In the current review, we summarise the literature linking type 2 immunity to improved adipose tissue function. We then discuss more recent evidence indicating that helminth infection can provide protection against metabolic syndrome. Lastly, we explore the possible contributions of altered nutrient uptake, adipose tissue function and/or the intestinal microbiota with the ability of helminths to alter metabolic status.

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“…Some studies have shown that alternatively activated M2 macrophages can promote AT browning and attenuate insulin resistance by enhancing intracellular glucose uptake, lipolysis, and FAO in mice. 110 In addition, the M2 macrophage phenotype was shown to increase the replication of β-cells, remedying the functional damage of β-cells that cannot be adequately replaced by exogenous insulin administration in diabetes. 111 The way that M2 macrophages promote β-cell proliferation was considered to be through the TGF-β1/Smad7/CyclinD1/ CyclinD2-dependent signalling pathway.…”

Section: Atm Polarization and Insulin Resistancementioning

confidence: 99%

Micro‐environment and intracellular metabolism modulation of adipose tissue macrophage polarization in relation to chronic inflammatory diseases

Zhu

Chen

et al. 2018

Diabetes Metabolism Res

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The accumulation and pro-inflammatory polarization of immune cells, mainly macrophages, in adipose tissue (AT) are considered crucial factors for obesity-induced chronic inflammatory diseases. In this review, we highlighted the role of adipose tissue macrophage (ATM) polarization on AT function in the obese state and the effect of the micro-environment and intracellular metabolism on the dynamic switch of ATMs into their pro-inflammatory or anti-inflammatory phenotypes, which may have distinct influences on obesity-related chronic inflammatory diseases. Obesity-associated metabolic dysfunctions, including those of glucose, fatty acid, cholesterol, and other nutrient substrates such as vitamin D and iron in AT, promote the pro-inflammatory polarization of ATMs and AT inflammation via regulating the interaction between ATMs and adipocytes and intracellular metabolic pathways, including glycolysis, fatty acid oxidation, and reverse cholesterol transportation. Focusing on the regulation of ATM metabolism will provide a novel target for the treatment of obesity-related chronic inflammatory diseases, including insulin resistance, cardiovascular diseases, and cancers.

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Injecting engineered anti-inflammatory macrophages therapeutically induces white adipose tissue browning and improves diet-induced insulin resistance

Cited by 36 publications

References 21 publications

Immunometabolism features of metabolic deregulation and cancer

Immunometabolism features of metabolic deregulation and cancer

The interplay of type 2 immunity, helminth infection and the microbiota in regulating metabolism

Micro‐environment and intracellular metabolism modulation of adipose tissue macrophage polarization in relation to chronic inflammatory diseases

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