Injectable self-curing bioactive acrylic-glass composites charged with specific anti-inflammatory/analgesic agent

Comparison of Three Dissolution Apparatuses for Testing Calcium Phosphate Pellets used as Ibuprofen Delivery Systems

“…Indeed, these bioceramics are biocompatible, bioactive, osteoconductive, and resorbable (25,26,29,30). Moreover, they can offer great interest as drug delivery systems (31)(32)(33)(34), achieving a therapeutic drug concentration directly at the site to be treated, while maintaining a low systemic drug level (35)(36)(37)(38). In order to evaluate the drug-substance release as well as the biocompatibility and the osteoconductivity of such delivery systems, in vivo studies must be carried out.…”

Synthesis, Spectral Studies, Pharmacological and Insect Antifeedant Activities of some (<i>E</i>)-1-(2-(2-Benzyloxy-3-Methacrylate))-1-Naphthyl Enones

“…While seeking they are worthful and produce satisfactory correlation in the multi-regression analysis [33] with σ I and σ R or F and R parameters. The generated multi-regression analysis equations for the δCO ester , δC β and δC βʹ carbons are given in (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). Antibacterial activity assay of prepared 2-benzyloxy-(3-methoxyacrylate)-1-naphthyl enones were performed using Kirby-Bauer [34] disc diffusion technique.…”

“…These synthetic methodology have merits over than conventional methods such as easy work-up procedure, handling technique, nonhazardousness, environmental pollution free from atmosphere, shorter reaction time and better yields [7]. Aryl enones and methacrylates possess many biological activities such as antimicrobial [8,9], acute toxicity [10], haemo toxicity [11], in-vivo toxicity [12], genotoxicity [13], antioxidant [14], anticancer [15], antiviral [16], site-specific peroral delivery [17] antiinflammatory/analgesic [18], anti plasmodial [19], anti-tuberclosis [20] and insect antifeedant [21,22] activities due to presence of carbonyl and vinyl segments present in their structural moieties. Various catalysts were used for synthesis of enones by conventional heating methods [4,23,24,25].…”

Anterior spinal column augmentation with injectable bone cements

“…The latter is biomechanically unsuitable to transfer physiological, multidirectional loads. To eliminate these shortcomings, various hybrid or composite cements, in which polymethyl methacrylate cement is modified by incorporating, e.g., hydroxyapatite, calcium aluminate or glass beads, or even injectable (porous) polymers that combine their bone augmentation characteristics with the ability to serve as a drug release system, are currently being developed and tested in vitro and in vivo [154][155][156][157][158][159]. It is to be expected that these studies will eventually lead to the development of a range of injectable bone cements that are tailored to specific (balloon-) vertebroplasty needs and indications.…”