Injectable pullulan hydrogel for the prevention of postoperative tissue adhesion

Bang, Sumi; Lee, Eungjae; Ko, Young-Gwang; Kim, Won Il; Kwon, Oh Hyeong

doi:10.1016/j.ijbiomac.2016.02.026

Cited by 54 publications

(13 citation statements)

References 20 publications

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“…We note that it has been widely used in many fields such as lubricants, pharmaceuticals, cosmetics, surfactants, and as a biodegradable reagent in metal extractions. 63 Most literature ascribes the degradation of PEG to an oxidation mechanism, but some have concluded that this degradation is due to a thermal mechanism 64 or even to high-speed stirring. 65 …”

Section: Resultsmentioning

confidence: 99%

One-Step Preparation of Highly Stable Copper–Zinc Ferrite Nanoparticles in Water Suitable for MRI Thermometry

et al. 2022

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Superparamagnetic ferrite nanoparticles coated with a polymer layer are widely used for biomedical applications. The objective of this work is to design nanoparticles as a magnetic resonance imaging (MRI) temperature-sensitive contrast agent. Copper–zinc ferrite nanoparticles coated with a poly(ethylene glycol) (PEG) layer are synthesized using a one-step thermal decomposition method in a polymer matrix. The resulting nanoparticles are stable in water and biocompatible. Using Mössbauer spectroscopy and magnetometry, it was determined that the grown nanoparticles exhibit superparamagnetic properties. Embedding these particles into an agarose gel resulted in significant modification of water proton relaxation times T 1 , T 2 , and T 2 * determined by nuclear magnetic resonance measurements. The results of the spin-echo T 2 -weighted MR images of an aqueous phantom with embedded Cu 0.08 Zn 0.54 Fe 2.38 O 4 nanoparticles in the presence of a strong temperature gradient show a strong correlation between the temperature and the image intensity. The presented results support the hypothesis that CuZn ferrite nanoparticles can be used as a contrast agent for MRI thermometry.

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Section: Resultsmentioning

confidence: 99%

One-Step Preparation of Highly Stable Copper–Zinc Ferrite Nanoparticles in Water Suitable for MRI Thermometry

et al. 2022

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“…To evaluate the effects of each mat as a physical barrier for the prevention of intra‐abdominal adhesion in a rat model, we divided the 30 male rats into five equal groups ( n = 5 rats per group). Defects of the adhesion model were made on both sides of the abdomen by exfoliating peritoneum (1 × 1 cm 2 ) with a scalpel blade and cecum by abrading the cecal serosa with a sandpaper (four sites per rat) . Rats in the control group were sutured after defects were made on both sides of the abdominal wall and cecum.…”

Section: Methodsmentioning

confidence: 99%

“…Defects of the adhesion model were made on both sides of the abdomen by exfoliating peritoneum (1 3 1 cm 2 ) with a scalpel blade and cecum by abrading the cecal serosa with a sandpaper (four sites per rat). 18 Rats in the control group were sutured after defects were made on both sides of the abdominal wall and cecum. In the experimental groups, chitosan-PLGA-PEO mats were applied to the damaged abdominal wall.…”

Section: Animal Testmentioning

confidence: 99%

Nanofiber mats composed of a chitosan-poly(d ,l -lactic-co -glycolic acid)-poly(ethylene oxide) blend as a postoperative anti-adhesion agent

Kim

et al. 2016

J. Biomed. Mater. Res.

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Postoperative tissue adhesion causes serious complications and suffering in 90% of patients after peritoneum surgery, while commercial anti-adhesion agents cannot completely prevent postoperative peritoneal adhesions. This study demonstrates electrospining of a blended solution of chitosan, poly(d,l-lactic-co-glycolic acid) (PLGA), and poly(ethylene oxide) (PEO) to fabricate a chitosan-based nanofibrous mat as a postoperative anti-adhesion agent. Rheological studies combined with scanning electron microscopy reveal that the spinnability of the chitosan-PLGA solution could be controlled by adjusting the blend ratio and concentration with average fiber diameter from 634 to 913 nm. Biodegradation of the nanofiber specimens showed accelerated hydrolysis by chitosan. Proliferation of fibroblasts and antimicrobial activity of nanofibers containing chitosan was analyzed. Abdominal defects with cecum adhesion in rats demonstrated that the blend nanofiber mats were effective in preventing tissue adhesion as a barrier (4 weeks after abdominal surgery) by coverage of exfoliated peritoneum and insufficient wound sites at the beginning of the wound healing process. Chitosan-PLGA-PEO blend nanofiber mats will provide a promising key as a postoperative anti-adhesion agent. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1906-1915, 2017.

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“…Thus, preventing adhesion after abdominal surgery is still a challenge in clinical practice. Although some approaches have been employed to prevent adhesions, such as liquid and solid film barriers, , unfortunately their anti-adhesion efficiency is limited. , Fluid anti-adhesion agents can produce a hydroflotation effect and separate the damaged peritoneal surfaces; however, their short residence time and unstable fixation to the injured tissue result in anti-adhesion failure . Solid film barriers, such as Seprafilm, also are considered one of the most ideal materials for preventing post-surgical adhesions, but they are brittle, and therefore, it is hard to cover an irregular surgical site completely. ,, …”

Section: Introductionmentioning

confidence: 99%

Combination of Polypropylene Mesh and in Situ Injectable Mussel-Inspired Hydrogel in Laparoscopic Hernia Repair for Preventing Post-Surgical Adhesions in the Piglet Model

Zhang

Long

et al. 2020

ACS Biomater. Sci. Eng.

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Polypropylene (PP) mesh has been used successfully for a long time in clinical practice as an impressive prosthesis for ventral hernia repair. To utilize a physical barrier for separating mesh from viscera is a general approach for preventing adhesions in clinical practice. However, a serious abdominal adhesion between the mesh and viscera can possibly occur post-hernia, especially with the small intestine; this can lead to a series of complications, such as chronic pain, intestinal obstruction, and fistula. Thus, determining how to prevent abdominal adhesions between the mesh and viscera is still an urgent clinical problem. In this study, a dopamine-functionalized polysaccharide derivative (oxidized-carboxymethylcellulose-g-dopamine, OCMC-DA) was synthesized; this was blended with carboxymethylchitosan (CMCS) to form a hydrogel (OCMC-DA/CMCS) in situ at the appropriate time. The physical and chemical properties of the hydrogel were characterized successfully, and its excellent biocompatibility was presented by the in vitro cell test. The combination of this hydrogel and PP mesh was used in laparoscopic surgery for repairing the abdominal wall defect, where the hydrogel could become fixed in situ on the PP mesh to form an anti-adhesion gel-mesh. The results showed that the gel-mesh could prevent abdominal adhesions effectively in the piglet model. Moreover, the histology and immunohistochemical staining proved that the gel-mesh could effectively alleviate the inflammation reaction and deposition of collagen around the mesh, and it did not disturb the integration between mesh and abdominal wall. Thus, the gel-mesh has superior tissue compatibility.

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Injectable pullulan hydrogel for the prevention of postoperative tissue adhesion

Cited by 54 publications

References 20 publications

One-Step Preparation of Highly Stable Copper–Zinc Ferrite Nanoparticles in Water Suitable for MRI Thermometry

One-Step Preparation of Highly Stable Copper–Zinc Ferrite Nanoparticles in Water Suitable for MRI Thermometry

Nanofiber mats composed of a chitosan-poly(d ,l -lactic-co -glycolic acid)-poly(ethylene oxide) blend as a postoperative anti-adhesion agent

Combination of Polypropylene Mesh and in Situ Injectable Mussel-Inspired Hydrogel in Laparoscopic Hernia Repair for Preventing Post-Surgical Adhesions in the Piglet Model

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