Injectable postoperative enzyme-responsive hydrogels for reversing temozolomide resistance and reducing local recurrence after glioma operation

Abstract

<p>Glioma is the most aggressive primary malignant brain tumor.</p>

Multi-responsive nanofibers composite gel for local drug delivery to inhibit recurrence of glioma after operation

“…100 µL T/PPS + TMZ hydrogel and T/PLGA + TMZ hydrogel were placed in a centrifuge tube, containing PBS buffer without or with one of the following reagents: MMP2 (100 ng mL −1 ), MMP9 (100 ng mL −1 ) and H 2 O 2 (1 mM). The drug concentration was determined as we previously reported [ 36 ]. In some tubes, MMP2 or MMP9 inhibitors were added.…”

Local delivery to malignant brain tumors: potential biomaterial-based therapeutic/adjuvant strategies

“…56 Hydrogels also offer an attractive means of delivering biomacromolecules such as proteins and DNA, as such cargoes can be loaded to hydrogels without denaturing hydrophobic interactions. 52 Lastly, hydrogels can be used to deliver chemotherapeutic drugs to GBM by either direct incorporation of the free drug [57][58][59][60][61][62][63] or incorporation of drug-loaded nano/micro carriers 56,[64][65][66] (Fig. 4B).…”

“…Several studies have explored the application of hydrogels for delivering chemotherapeutic agents locally to GBM. 56,[58][59][60]63,65,[67][68][69] Akbar et al developed a biodegradable PLGA based hydrogel comprised of a mixture of PLGA: plastici-zer with a ratio of (40 : 60) to load and deliver TMZ directly into the resection cavity. 57 Plasticizers with different hydrophilicity and hydrophobicity such as polyethylene glycol (PEG), N-methyl pyrrolidone (NMP), and acetyl triethyl citrate (ATEC) were studied which showed good biocompatibility.…”

Injectable Biomaterials for Treatment of Glioblastoma

“…Ultimately, this dual‐acting biomaterial depot increased the efficacy of TMZ for inhibiting tumor growth by combatting chemoresistance with delivery of the MGMT inhibitor (Figure 5c–f). [ 67 ]…”