Injectable Polymers

Unterman, Shimon; and, Norman A. Marcus; Elisseeff, Jennifer H.

doi:10.1002/9781118015810.ch17

Cited by 1 publication

(1 citation statement)

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“…Polymer‐based delivery has received increasing attention in the field of medicinal chemistry and biotechnology including the delivery of short interfering RNA (siRNA) . The ability to control the character of the polymer structure in terms of size and monomer incorporation provides a unique opportunity for chemists to optimize the delivery vehicle in concert with its payload .…”

Section: Introductionmentioning

confidence: 99%

Comparison of flow and batch polymerization processes for production of vinyl ether terpolymers for use in the delivery of siRNA

Nyrop

Soheili

Xiang

et al. 2014

J. Polym. Sci. Part A: Polym. Chem.

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Synthetic polymers represent a modifiable class of materials that can serve as adjuvants to address challenges in numerous biomedical and medicinal chemistry applications including the delivery of siRNA. Polymer‐based therapeutics offer unique challenges in both synthesis and characterization as compared to small molecule therapeutics. The ability to control the structure of the polymer is critical in creating a therapeutic. Reported herein, are batch and flow polymerization processes to produce amphiphilic terpolymers through a Lewis acid BF3OEt2‐catalyzed polymerization. These processes focus on controlling reaction variables, which affect polymer structure in this rapid, exothermic, nonliving cationic polymerization. In addition to analytical characterization of the polymers, the in vivo activity of the polymer‐siRNA conjugates is also highlighted—demonstrating that the method of synthesis does affect the in vivo activity of the resulting polymer conjugate. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 1119–1129

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Section: Introductionmentioning

confidence: 99%