Comparison of flow and batch polymerization processes for production of vinyl ether terpolymers for use in the delivery of siRNA

Nyrop, Jason L.; Soheili, Arash; Xiang, Rong; Meng, Fanyu; Waldman, Jacob H.; Jia, Xiujuan; Parmar, Rubina Giarre; Thuronyi, Benjamin W.; Williams, Jonathan; DiMichele, Lisa; Journet, Michel; Howell, Bonnie J.; Mao, Bing; Davies, Ian W.; Colletti, Steven L.; Sepp‐Lorenzino, Laura; Guidry, Erin N.

doi:10.1002/pola.27094

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…The ability to control the character of the polypeptide structure in terms of size and monomer incorporation provides a unique opportunity for chemists to optimize the delivery vehicle in concert with its payload. Therefore, the need for improved and robust methods for the synthesis of polymers is critical and may provide an opportunity to create a differentiated therapeutic . N ‐carboxyanhydride (NCA) polymerization represents a versatile approach toward the synthesis of peptide macromolecules .…”

Section: Introductionmentioning

confidence: 99%

Size controlled synthesis of ornithine‐based polypeptides by ring‐opening polymerization of α‐(amino acid)‐N‐carboxyanhydrides

Pei

Liao

Williams

et al. 2015

J. Polym. Sci., Part A: Polym. Chem.

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Polypeptide‐based drug delivery has become increasingly important in the field of nanomedicine, with N‐carboxyanhydride (NCA) polymerization representing a versatile approach toward their synthesis. Organocatalytic polymerization conditions have been developed to access moderate molecular weight polypeptides with narrow chain length distributions by adding acidic additives to triethylamine catalyzed NCA polymerizations. This method produces polypeptides of predictable sizes and is operationally simple, allowing the synthesis of polypeptides with different targeted sizes for use in a variety of applications including drug delivery.

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Section: Introductionmentioning

confidence: 99%

Size controlled synthesis of ornithine‐based polypeptides by ring‐opening polymerization of α‐(amino acid)‐N‐carboxyanhydrides

Pei

Liao

Williams

et al. 2015

J. Polym. Sci., Part A: Polym. Chem.

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Ionic Polymerisation and New Approaches to Polymerisation under Flow Conditions

Brocken¹,

Baxendale²

2019

Flow Chemistry

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Although ionic polymerisations are a valuable methodology historically they are less widely used because they are considered capricious, requiring significantly more optimisation due to their sensitivity to the specific reaction and processing conditions. Increasingly though flow processing regimes are being successfully implemented to allow better control over reaction parameters and facilitate a more consistent processing environment; this has also shown promising results for challenging reactions such as ionic polymerisation. Furthermore, as flow chemistry is becoming more widely implemented additional and complementary processing tools such as photochemical, supported reagents and enzymatic based plug-in reactors are being evaluated for their ability to expand the range of polymers on offer. Supplementing this era of advanced and accelerated synthesis is an explosion in direct integrated analysis routines and the development of smart self-optimising platforms capable of self-sustained assembly of new polymers. Whilst the machines have been taking over the physical synthesis, chemists have been starting to think beyond simply the isolated stage of polymer synthesis, considering options to create more encompassing work-flows. The next generations of polymer synthesis will encompass all aspects of synthesis, purification and final analysis as a single unified sequence. These new polymer products will ultimately be used for new applications such as light-emitting diodes and in photovoltaics.

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Highlights from the Flow Chemistry Literature 2014 (Part 1)

Glasnov

2014

J Flow Chem

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In this section of the journal, the continuous-flow chemistry literature of the preceding months is presented. Included are articles published in the period October-December 2013 and January-March 2014. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed ordered by journal name, with review articles grouped at the end. An efficient continuous-flow approach towards the synthesis of dipeptides has been accomplished. Various amino acids can be rapidly converted into highly reactive species via reaction with inexpensive triphosgene. Following in situ reaction with a second amino acid affords the corresponding dipeptide (5 s total reaction time). High yields and low rates of epimerization (≤3 %) were achieved. The reaction proceeds at room temperature, and the side products are only CO 2 and an HCl salt of the used organic base.

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Comparison of flow and batch polymerization processes for production of vinyl ether terpolymers for use in the delivery of siRNA

Cited by 3 publications

References 33 publications

Size controlled synthesis of ornithine‐based polypeptides by ring‐opening polymerization of α‐(amino acid)‐N‐carboxyanhydrides

Size controlled synthesis of ornithine‐based polypeptides by ring‐opening polymerization of α‐(amino acid)‐N‐carboxyanhydrides

Ionic Polymerisation and New Approaches to Polymerisation under Flow Conditions

Highlights from the Flow Chemistry Literature 2014 (Part 1)

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