Injectable or transdermal flunixin meglumine improves pregnancy rates in embryo transfer recipient beef cows without altering returns to estrus

Kasimanickam, R.; Kasimanickam, Vanmathy; Gold, Jenifer R.; Moore, Daniel B.; Kastelic, John P.; Pyrdek, D.; Ratzburg, Kamron

doi:10.1016/j.theriogenology.2019.08.011

Cited by 16 publications

(20 citation statements)

References 46 publications

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“…Further evidence for poor uterine receptivity as a cause of infertility was the finding that 14 of 37 (32.4%) recipients receiving five embryos failed to become pregnant to any embryo ( Martins et al, 2018a ). Examples of cow factors associated with poor P/ET are low body condition score ( Mapletoft et al, 1986 ; Wallace et al 2011 ), poor weight gain ( Fernandes et al, 2016 ), lactation or parity in dairy cattle ( Dochi et al, 1998 ; Hasler, 2001 ; Ferraz et al, 2016 ), temperament ( Kasimanickam et al, 2018 , 2019 ), and periparturient or postpartum disease ( Ferraz et al, 2016 ; Ribeiro et al, 2016 ; Barbosa et al, 2018 ; Estrada-Cortés et al, 2019 ).…”

Section: Causes Of Pregnancy Loss Associated With Etmentioning

confidence: 99%

“…That one or more of insults to the reproductive tract are potentially deleterious to pregnancy establishment is indicated by observations that the difficulty in passing the cervix and depositing the embryo in the uterus is negatively associated with P/ET ( Jaśkowski et al, 2010 ; Kasimanickam et al, 2018 , 2019 ; Alkan et al, 2020 ). Moreover, the physical characteristics of the transfer instrument have been reported to affect pregnancy success.…”

Section: Causes Of Pregnancy Loss Associated With Etmentioning

confidence: 99%

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The incompletely fulfilled promise of embryo transfer in cattle—why aren’t pregnancy rates greater and what can we do about it?

Hansen

2020

Journal of Animal Science

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Typically, bovine embryos are transferred into recipient females about day 7 after estrus or anticipated ovulation, when the embryo has reached the blastocyst stage of development. All the biological and technical causes for failure of a female to produce a blastocyst 7 d after natural or artificial insemination (AI) are avoided when a blastocyst-stage embryo is transferred into the female. It is reasonable to expect, therefore, that pregnancy success would be higher for embryo transfer (ET) recipients than for inseminated females. This expectation is not usually met unless the recipient is exposed to heat stress or is classified as a repeat-breeder female. Rather, pregnancy success is generally similar for ET and AI. The implication is that either one or more of the technical aspects of ET have not yet been optimized or that underlying female fertility that causes an embryo to die before day 7 also causes it to die later in pregnancy. Improvements in pregnancy success after ET will depend upon making a better embryo, improving uterine receptivity, and forging new tools for production and transfer of embryos. Key to accelerating progress in improving pregnancy rates will be the identification of phenotypes or phenomes that allow the prediction of embryo competence for survival and maternal capacity to support embryonic development.

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Section: Causes Of Pregnancy Loss Associated With Etmentioning

confidence: 99%

Section: Causes Of Pregnancy Loss Associated With Etmentioning

confidence: 99%

The incompletely fulfilled promise of embryo transfer in cattle—why aren’t pregnancy rates greater and what can we do about it?

Hansen

2020

Journal of Animal Science

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“…We postulate that the damage to biological compounds leading to metabolic or pathological disorders and inflammation, such as arachidonic acid, would result in discomfort and subsequently reduce well-being. This is supported by some works who found a positive correlation between blood cortisol and isoprostane concentrations (29,30). The integration of uncomfortable experiences leads to negative emotions, thus reducing hedonic well-being.…”

Section: Oxidative Stressmentioning

confidence: 57%

“…Some recent works have shown a positive correlation between isoprostanes, which results from oxidant conversion of arachidonic acid, and cortisol. These experiments explored the effects of a non-steroidal anti-inflammatory drug on reproductive performance of cattle (29,30). As mentioned previously, isoprostanes result from the peroxidation of arachidonic acid by oxidants and it has been suggested that they are the pathophysiological mediators of oxidative damage (28).…”

Section: Linking Oxidative and Physiological Stressmentioning

confidence: 99%

How Dietary Diversity Enhances Hedonic and Eudaimonic Well-Being in Grazing Ruminants

Beck

Gregorini

2020

Front. Vet. Sci.

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Ruminants evolved in diverse landscapes of which they utilized, by choice, a diverse arrangement of plants (grasses, forbs, and trees) for food. These plants provide them with both primary (carbohydrates, protein, etc.) and secondary (phenolics, terpenes, etc.) compounds (PPC and PSC, respectively). As no one plant could possibly constitute a "balanced-diet," ruminants mix diets so that they can exploit arrangements of PPC to meet their individual requirements. Diet mixing also allows for ruminants to ingest PSC at levels, acquiring their benefits such as antioxidants and reduced gastrointestinal parasites, without overstepping thresholds of toxicity. Meeting dietary requirements is assumed to provide satisfaction through achieving positive internal status and comfort, thereby a sense of hedonic (happiness through pleasure) well-being. Furthermore, choice including dietary choice is a factor influencing well-being of ruminants in a manner akin to that in humans. Choice may facilitate eudaimonic (happiness through pursuit of purpose) well-being in livestock. Nutritional status plays an integral role in oxidative stress, which is linked with illness. Several diseases in livestock have been directly linked to oxidative stress. Mastitis, metritis, hypocalcaemia, and retained placenta occur in animals transitioning from dry to lactating and have been linked to oxidative stress and such a stress has likewise been linked to diseases that occur in growing livestock as well, such as bovine respiratory disease. The link between physiological stress and oxidative stress is not well-defined in livestock but is evident in humans. As dietary diversity allows animals to select more adequately balanced diets (improved nutrition), take advantage of PSC (natural antioxidants), and allows for choice (improved animal well-being) there is a strong possibility for ruminants to improve their oxidative status and thus health, well-being, and therefor production. The purposes of this review are to first, provide an introduction to oxidative and physiological stress, and nutritional status as effected by dietary diversity, with special attention to providing support and on answering the "how." Second, to provide evidence of how these stresses are connected and influence each other, and finally discuss how dietary diversity provides a beneficial link to all three and enhances both eudaimonic and hedonic well-being.

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“…Áûëî ïîêàçàíî, ÷òî ïðè ñíèaeåíèè óðîâíÿ ïðîãåñòåðîíà â êðîâè ó ðåöèïèåíòà ïîêàçàòåëè ñòåëüíîñòè ñíèaeàþòñÿ: ïðè ïîêàçàòåëå ïðîãåñòåðîíà áîëåå 2,6 íã/ìë ïîêàçàòåëü ïðèaeèâëÿåìîñòè äîñòèãàë 52,4 %, ïðè ïîêàçàòåëå óðîâíÿ ïðîãåñòåðîíà â äèàïàçîíå 2,5 -1,0 íã/ìë óðîâåíü ïðèaeèâëÿåìîñòè ó ðåöèïèåíòîâ ñîñòàâëÿë 16,7 -37,5 % [19]. Ïî äàííûì äðóãèõ èññëåäîâàòåëåé, ïðè áîëåå âûñîêèõ êîíöåíòðàöèÿõ ïðîãåñòåðîíà â êðîâè ó ðåöèïèåíòà (> 4,5 íã / ìë), ( [24]. Àíàëîãè÷íîãî ìíåíèÿ ïðèäåðaeèâàþòñÿ Spell A.R.…”

Section: äëÿ öèòèðîâàíèÿ / For Citationunclassified

Factors affecting embryo engraftment in recipient cows

Skachkova¹

2019

Vetkorm

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Injectable or transdermal flunixin meglumine improves pregnancy rates in embryo transfer recipient beef cows without altering returns to estrus

Cited by 16 publications

References 46 publications

The incompletely fulfilled promise of embryo transfer in cattle—why aren’t pregnancy rates greater and what can we do about it?

The incompletely fulfilled promise of embryo transfer in cattle—why aren’t pregnancy rates greater and what can we do about it?

How Dietary Diversity Enhances Hedonic and Eudaimonic Well-Being in Grazing Ruminants

Factors affecting embryo engraftment in recipient cows

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