Injectable methylcellulose hydrogel containing silver oxide nanoparticles for burn wound healing

Kim, Min Hee; Park, Hanna; Nam, Hyung Chan; Park, Se Ra; Jung, Jongwan; Park, Won Ho

doi:10.1016/j.carbpol.2017.11.109

Cited by 110 publications

(53 citation statements)

References 23 publications

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“…In addition, ISFIHs can be tailored to mimic the physicochemical properties of human tissues and promote the wound healing process [ 26 , 27 ]. Given these unique characteristics, ISFIHs have attracted increasing attention in recent years and are widely used in various biomedical applications [ 14 , 28 , 29 ]. However, until now, there have been no reports on ISFIHs for treating gastric bleeding and wound healing after endoscopic treatment.…”

Section: Introductionmentioning

confidence: 99%

Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing

et al. 2021

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Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are well-established therapeutics for gastrointestinal neoplasias, but complications after EMR/ESD, including bleeding and perforation, result in additional treatment morbidity and even threaten the lives of patients. Thus, designing biomaterials to treat gastric bleeding and wound healing after endoscopic treatment is highly desired and remains a challenge. Herein, a series of injectable pH-responsive self-healing adhesive hydrogels based on acryloyl-6-aminocaproic acid (AA) and AA-g-N-hydroxysuccinimide (AA-NHS) were developed, and their great potential as endoscopic sprayable bioadhesive materials to efficiently stop hemorrhage and promote the wound healing process was further demonstrated in a swine gastric hemorrhage/wound model. The hydrogels showed a suitable gelation time, an autonomous and efficient self-healing capacity, hemostatic properties, and good biocompatibility. With the introduction of AA-NHS as a micro-cross-linker, the hydrogels exhibited enhanced adhesive strength. A swine gastric hemorrhage in vivo model demonstrated that the hydrogels showed good hemostatic performance by stopping acute arterial bleeding and preventing delayed bleeding. A gastric wound model indicated that the hydrogels showed excellent treatment effects with significantly enhanced wound healing with type I collagen deposition, α-SMA expression, and blood vessel formation. These injectable self-healing adhesive hydrogels exhibited great potential to treat gastric wounds after endoscopic treatment.

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Section: Introductionmentioning

confidence: 99%

Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing

et al. 2021

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“…They used Sprague four-week-old field hairs for this experiment. Field was performed under controlled conditions of temperature, humidity and light [38]. Their histopathological examina-tion showed that the part of the wound treated with MC hydrogel containing silver oxide nanoparticles was more successful than the untreated wound.…”

Section: Wound Dressingmentioning

confidence: 99%

“…Their histopathological examina-tion showed that the part of the wound treated with MC hydrogel containing silver oxide nanoparticles was more successful than the untreated wound. It has been reported that the healing rate of burn wounds with MC hydrogel is significantly increased [38] .The treatment pattern of burn wounds was also studied to examine untreated tissue. Particles were evaluated by biological dyes on days 1, 3, 7, 14, and 21.…”

Section: Wound Dressingmentioning

confidence: 99%

“…Particles were evaluated by biological dyes on days 1, 3, 7, 14, and 21. The results showed that MC hydrogels without silver nanoparticles caused inflammation and tissue necrosis, while hydrogels containing silver nanoparticles without inflammation and necrosis [38]. Hydrogel-based dressings can absorb water several times their dry weight and for Absorbing wound secretions and helping to reduce the temperature at the wound site and creating a moist environment will be helpful.…”

Section: Wound Dressingmentioning

confidence: 99%

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A Review of Hydrogels, Their Properties and Applications in Medicine

Chamkouri

2021

AJBSR

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“…Through these methods, highly stable and uniformly distributed silver particles were produced in resins, however they require high energy and long periods of time. In previous works, different green reducing agents were employed to obtain Ag 0 in hydrogels such as extract of blackberry [21] and cologynths seed [22]. As glucose is an edible and abundant monosaccharide widely used in many fields, it can easily reduce Ag + ions to Ag 0 .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Superabsorbent Polymers from Tara Gum Grafted Poly(Acrylic acid) Embedded Silver Particles

et al. 2018

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Tara gum/silver composite superabsorbent polymers were synthesized with tara gum grafted poly(acrylic acid), using K 2 S 2 O 8 (KPS) as an initiator and N,N -methylenebisacrylamide (MBA) as a cross-linker. The products were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscope (TEM), scanning electron microscope (SEM) and X-ray photoelectron spectroscopy (XPS). The results showed that the silver ions were partially reduced to Ag 0 and the amorphous nanoparticles containing Ag 0 and Ag 2 O were around 10~50 nm in size The tara gum/silver composite superabsorbent polymers exhibited an interconnected porous structure with strong water absorption capacity. The swelling ratio of each product could reach 473 g/g in distilled water and 62 g/g in 0.9% NaCl solution. The antimicrobial activity of the samples against Staphylococcus aureus and Escherichia coli increased with the addition of AgNO 3 from 0 to 125 mg. This work indicates that the developed tara gum/silver composite superabsorbent polymers can be potentially used for biomedical applications.

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Injectable methylcellulose hydrogel containing silver oxide nanoparticles for burn wound healing

Cited by 110 publications

References 23 publications

Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing

Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing

A Review of Hydrogels, Their Properties and Applications in Medicine

Antibacterial Superabsorbent Polymers from Tara Gum Grafted Poly(Acrylic acid) Embedded Silver Particles

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