A Review of Hydrogels, Their Properties and Applications in Medicine

Chamkouri, Hossein

doi:10.34297/ajbsr.2021.11.001682

Cited by 49 publications

(35 citation statements)

References 30 publications

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“…In terms of their microstructure, hydrogels are similar to the intercellular matrix of many tissues and are capable of imitating its physicochemical properties. Thus, they are an ideal cellular microenvironment for cell proliferation and differentiation [ 7 , 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrogels on the Base of Modified Chitosan and Hyaluronic Acid Mix as Polymer Matrices for Cytostatics Delivery

Vil’danova

Лобов

Спирихин

et al. 2022

Gels

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The development of biodegradable polysaccharide hydrogel matrices for cytostatic delivery can improve the therapeutic results of patients by prolonging the action of the drug, reducing its toxicity and providing additional biological activity by polysaccharides. In this work, N-succinyl chitosan/hyaluronic acid dialdehyde/cytostatic formulations have been prepared using two different chitosan grades (30 kDa and 150 kDa) and hyaluronic acid dialdehyde. The interaction of amino groups of N-succinyl chitosan and aldehydes of hyaluronic acid resulted in the formation of azomethine bonds and was demonstrated using 13C NMR. The elastic properties of the obtained hydrogels determine their use as implants. Two cytostatics—5-fluorouracil and mitomycin C were chosen as drugs because of their using both in oncology and in ophthalmology for the surgical treatment of glaucoma. Hydrogel formulations containing cytostatic were prepared and drug release was studied using in vitro dialysis method. It was established that the molecular weight of N-succinyl chitosan and rheological properties of hydrogel influenced the drug release behavior of the gelling delivery system. Formulations prepared from N-succinyl chitosan with greatest molecular weight and mitomycin C were found to be the most promising for medical application due to their rheological properties and prolonged drug release. Mild preparation conditions, simplicity of the technique, short gelation time (within a minute), 100% yield of hydrogel, suitability for drug release applications are the main advantages of the obtained hydrogels.

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Section: Introductionmentioning

confidence: 99%

Hydrogels on the Base of Modified Chitosan and Hyaluronic Acid Mix as Polymer Matrices for Cytostatics Delivery

Vil’danova

Лобов

Спирихин

et al. 2022

Gels

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“… Swelling properties: In standard hydrogel systems, drug release depends on swelling or contraction of the hydrogel and diffusion of the drug through the polymer network. Temperature, pH, ion concentration, the molecular weight of polymers, and crosslinking capability are important parameters that participate in the collapse or phase transfer of the hydrogel [ 66 ]. Mechanical properties: These properties of scaffold play an important role in regulating cell behavior.…”

Section: Main Textmentioning

confidence: 99%

“…Stiffness, elasticity, tensile strength, stress relaxation, self-healing, and degradation, can be controlled at various levels to meet specific requirements for specific applications [ 67 ]. Biological Properties: Biocompatibility, non-toxicity, non-carcinogenicity, non-inflammatory, and biodegradability are the main requirements that all types of hydrogel should possess [ 66 ]. …”

Section: Main Textmentioning

confidence: 99%

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Hydrogel based tissue engineering and its future applications in personalized disease modeling and regenerative therapy

Chaudhary

Chakraborty

2022

Beni-Suef Univ J Basic Appl Sci

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Background Evolution in the in vitro cell culture from conventional 2D to 3D technique has been a significant accomplishment. The 3D culture models have provided a close and better insight into the physiological study of the human body. The increasing demand for organs like liver, kidney, and pancreas for transplantation, rapid anti-cancer drug screening, and the limitations associated with the use of animal models have attracted the interest of researchers to explore 3D organ culture. Main body Natural, synthetic, and hybrid material-based hydrogels are being used as scaffolds in 3D culture and provide 'close-to-in vivo’ structures. Organoids: the stem cell-derived small size 3D culture systems are now favored due to their ability to mimic the in-vivo conditions of organ or tissue and this characteristic has made it eligible for a variety of clinical applications, drug discovery and regenerative medicine are a few of the many areas of application. The use of animal models for clinical applications has been a long-time ethical and biological challenge to get accurate outcomes. 3D bioprinting has resolved the issue of vascularization in organoid culture to a great extent by its layer-by-layer construction approach. The 3D bioprinted organoids have a popular application in personalized disease modeling and rapid drug development and therapeutics. Short conclusions This review paper, focuses on discussing the novel organoid culture approach, its advantages and limitations, and potential applications in a variety of life science areas namely cancer research, cell therapy, tissue engineering, and personalized medicine and drug discovery. Graphical Abstract

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“…Chemical crosslinking methods may also be used. However, chemical crosslinkers are often toxic and may affect the material’s biocompatibility [ 14 ]. These hydrogels can be prepared using injection molding, irradiation, cast drying, and freeze–thawing (FT) [ 12 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement

Branco

Oliveira

Monteiro

et al. 2022

Gels

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Polyvinyl alcohol (PVA) hydrogels have been widely studied for cartilage replacement due to their biocompatibility, chemical stability, and ability to be modified such that they approximate natural tissue behavior. Additionally, they may also be used with advantages as local drug delivery systems. However, their properties are not yet the most adequate for such applications. This work aimed to develop new PVA-based hydrogels for this purpose, displaying improved tribomechanical properties with the ability to control the release of diclofenac (DFN). Four types of PVA-based hydrogels were prepared via freeze-thawing: PVA, PVA/PAA (by polyacrylic acid (PAA) addition), PVA/PAA+PEG (by polyethylene glycol (PEG) immersion), and PVA/PAA+PEG+A (by annealing). Their morphology, water uptake, mechanical and rheological properties, wettability, friction coefficient, and drug release behavior were accessed. The irritability of the best-performing material was investigated. The results showed that the PAA addition increased the swelling and drug release amount. PEG immersion led to a more compact structure and significantly improved the material’s tribomechanical performance. The annealing treatment led to the material with the most suitable properties: besides presenting a low friction coefficient, it further enhanced the mechanical properties and ensured a controlled DFN release for at least 3 days. Moreover, it did not reveal irritability potential for biological tissues.

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A Review of Hydrogels, Their Properties and Applications in Medicine

Abstract: This work is licensed under Creative Commons Attribution 4.0 License AJBSR.MS.ID.001682.

Cited by 49 publications

References 30 publications

Hydrogels on the Base of Modified Chitosan and Hyaluronic Acid Mix as Polymer Matrices for Cytostatics Delivery

Hydrogels on the Base of Modified Chitosan and Hyaluronic Acid Mix as Polymer Matrices for Cytostatics Delivery

Hydrogel based tissue engineering and its future applications in personalized disease modeling and regenerative therapy

PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement

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