Injectable hydrogels with high drug loading through B–N coordination and ROS-triggered drug release for efficient treatment of chronic periodontitis in diabetic rats

Zhao, Xiaodan; Yang, Yuxuan; Yu, Jing; Ding, Rui; Pei, Dandan; Zhang, Yanfeng; He, Gang; Cheng, Yilong; Li, Ang

doi:10.1016/j.biomaterials.2022.121387

Cited by 69 publications

(54 citation statements)

References 65 publications

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“…Aspirin/erythropoietin was used to fill the successfully created and proven to be helpful in periodontium regeneration CS/gelatin hydrogel [ 32 ]. The dual drug-loaded oxidized dextran and phenylboronic acid-functionalized polyethylene imine hydrogel, a novel potential therapeutic agent, may be beneficial for the therapy of chronic periodontitis with diabetes mellitus [ 33 ]. Innovative hybrid hydrogel offers enormous potential as an injectable platform technology with a variety of applications in the eradication of mouth infections such as periodontal disease and pulpal pathology [ 34 ].…”

Section: Reviewmentioning

confidence: 99%

Injectable and Self-Invigorating Hydrogel Applications in Dentistry and Periodontal Regeneration: A Literature Review

Shirbhate¹,

Bajaj²

2022

Cureus

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Hydrogels are thought of as unique polymers utilized to build new materials, and two key factors that impact their features are their hydrophilicity and the degree of cross-linking of the polymer chains. An injectable hydrogel is based on the hypothesis that certain biomaterials can be injected into the body as a liquid and progressively solidify there. The scientific research community was intrigued and interested by its discovery. The hydrophilic polymers that are used to make hydrogels can typically be split into two groups: natural polymers derived from tissues or other sources of natural materials, and synthetic polymers produced by combining principles from organic chemistry and molecular engineering. A variety of organic and synthetic biomaterials, such as chitosan, collagen or gelatin, alginate, hyaluronic acid, heparin, chondroitin sulfate, polyethylene glycol, and polyvinyl alcohol, are used to generate injectable hydrogels. A promising biomaterial for the therapeutic injection of cells and bioactive chemicals for tissue regeneration in both dentistry and medicine, injectable hydrogels have recently attracted attention. Since injectable scaffolds can be implanted with less invasive surgery, their application is seen as a viable strategy in the regeneration of craniofacial tissue. Treatment for periodontitis that effectively promotes periodontal regeneration involves injecting a hydrogel that contains medications with simultaneous anti-inflammatory and tissueregenerating capabilities. The advantages of injectable hydrogel for tissue engineering are enhanced by the capability of three-dimensional encapsulation. A material's injectability can be attributed to a variety of mechanisms. The hydrogels work well to reduce inflammation and promote periodontal tissue regeneration.

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Section: Reviewmentioning

confidence: 99%

Injectable and Self-Invigorating Hydrogel Applications in Dentistry and Periodontal Regeneration: A Literature Review

Shirbhate¹,

Bajaj²

2022

Cureus

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“…[ 7 ] Especially by simply adding these antibiotics to ointments and applying the resultant ointments to the target area, the release of antibiotics would kill the pathogens effectively, bringing about complete inflammatory eradication. [ 8 ] Despite with many successes of the antibiotics additive ointments in dental preparations, like the commercial production of minocycline ointments, which are applied in clinical practice worldwide, the continuous gingival crevicular fluid flow in the gingival sulcus would weaken the drug retention at the periodontitis site, leading to repeated administration of ointments and unavoidable drug waste. [ 9 , 10 ] Additionally, the passive release of actives from these ointments has also resulted in limited local antibiotics concentration and low therapeutic efficiency.…”

Section: Introductionmentioning

confidence: 99%

Abalone‐Inspired Adhesive and Photo‐Responsive Microparticle Delivery Systems for Periodontal Drug Therapy

et al. 2022

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Antibiotics provide promising strategies for treating periodontitis, while their delivery and controllable release with desired oral retention remain challenging. Here, inspired by the unique suction-cup structures of abalones, a novel adhesive and photo-responsive microparticle (MP) delivery system is developed to treat periodontitis through microfluidic electrospray technology. Such MPs are generated by quickly ionic cross-linking of sodium alginate together with photo-curing of poly(ethylene glycol) diacrylate of the distorted microfluidic droplets during their high-speed dropping into calcium chloride solution. Attributing to their unique concave structures, the abalone-inspired MPs exhibit desired underwater adhesion ability and stability under running water. In addition, due to the loading of antibiotics minocycline hydrochloride and near-infrared (NIR)-responsive black phosphorus during their fabrication, the resultant MPs can not only eradicate bacteria directly, but also realize a controllable and effective drug release upon NIR irradiation. Based on these features, it is demonstrated from in vivo periodontitis that the abalone-inspired MPs are firmly adhesive and can controlled-release drugs on the tooth, and thus have outstanding antibacterial efficacy against Porphyromonas gingivalis. These results indicate the particular values of the abalone-inspired MPs for oral-related disease treatment.

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“…A deeper understanding of the mechanism of the signaling pathways and the target tissues of metformin provided compelling evidence that metformin can be applied to treat various diseases, including coronavirus disease 2019 (COVID-19) [ 3 ]. Importantly, metformin has demonstrated a significant contribution to repairing bone defects and promoting angiogenesis [ 4 , 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Metformin Delivery via Biomaterials on Bone and Dental Tissue Engineering

Zhu

Zhao

et al. 2022

IJMS

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Bone tissue engineering is a promising approach that uses seed-cell-scaffold drug delivery systems to reconstruct bone defects caused by trauma, tumors, or other diseases (e.g., periodontitis). Metformin, a widely used medication for type II diabetes, has the ability to enhance osteogenesis and angiogenesis by promoting cell migration and differentiation. Metformin promotes osteogenic differentiation, mineralization, and bone defect regeneration via activation of the AMP-activated kinase (AMPK) signaling pathway. Bone tissue engineering depends highly on vascular networks for adequate oxygen and nutrition supply. Metformin also enhances vascular differentiation via the AMPK/mechanistic target of the rapamycin kinase (mTOR)/NLR family pyrin domain containing the 3 (NLRP3) inflammasome signaling axis. This is the first review article on the effects of metformin on stem cells and bone tissue engineering. In this paper, we review the cutting-edge research on the effects of metformin on bone tissue engineering. This includes metformin delivery via tissue engineering scaffolds, metformin-induced enhancement of various types of stem cells, and metformin-induced promotion of osteogenesis, angiogenesis, and its regulatory pathways. In addition, the dental, craniofacial, and orthopedic applications of metformin in bone repair and regeneration are also discussed.

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Injectable hydrogels with high drug loading through B–N coordination and ROS-triggered drug release for efficient treatment of chronic periodontitis in diabetic rats

Cited by 69 publications

References 65 publications

Injectable and Self-Invigorating Hydrogel Applications in Dentistry and Periodontal Regeneration: A Literature Review

Injectable and Self-Invigorating Hydrogel Applications in Dentistry and Periodontal Regeneration: A Literature Review

Abalone‐Inspired Adhesive and Photo‐Responsive Microparticle Delivery Systems for Periodontal Drug Therapy

Effects of Metformin Delivery via Biomaterials on Bone and Dental Tissue Engineering

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