Injectable hydrogels for personalized cancer immunotherapies

Application of 3D, 4D, 5D, and 6D bioprinting in cancer research: what does the future look like?

“…These cells are then integrated into a suitable biomaterial, chosen based on the specific bioprinting method employed. 115–117 This development of in vitro cancer models capable of emulating drug responses unique to each patient is a major focus in personalized medicine. 118 Despite this, the current technologies used in crafting such models primarily reproduce only the morphological diversity found in human cancer tissues.…”

ROS-Responsive Bola-Lipid Nanoparticles as a Codelivery System for Gene/Photodynamic Combination Therapy

“…Cancer has long been one of the deadliest diseases threatening human life. − Due to the complexity, diversity, and heterogeneity of tumors, traditional treatment methods have limited treatment efficiency and cannot completely cure cancer in most cases . In recent years, the progress of cancer treatment has gradually shifted from monotherapy to the combination of multiple treatment methods. , This multimodal therapy refers to the combination of two or more medical approaches such as surgery, chemotherapy (CT), , radiotherapy (RT), , high-intensity focused ultrasound (HIFU), gene therapy, , photodynamic therapy (PDT), , photothermal therapy (PTT), , and immunotherapy. , Different from monotherapy, multimodal treatments have the characteristics of reducing drug dose, enhancing efficacy, and fewer side effects, showing much higher promise for the antitumor therapy. , …”

“…5,6 This multimodal therapy refers to the combination of two or more medical approaches such as surgery, 7 chemotherapy (CT), 8,9 radiotherapy (RT), 10,11 high-intensity focused ultrasound (HIFU), 12 gene therapy, 13,14 photodynamic therapy (PDT), 15,16 photothermal therapy (PTT), 17,18 and immunotherapy. 19,20 Different from monotherapy, multimodal treatments have the characteristics of reducing drug dose, enhancing efficacy, and fewer side effects, showing much higher promise for the antitumor therapy. 6,21 Several studies have shown that combining PDT with gene therapy can synergistically improve the killing efficiency of tumor cells.…”

Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and Alternatives

“…Therefore, the need for more effective and less toxic treatments remains a pressing concern in the scientific and clinical communities. Current and continuous research endeavors hold the promise of uncovering novel strategies to address the complexities of GBM treatment [ 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. Researchers are actively engaged in exploring novel strategies that could provide more effective and advanced solutions for managing the complex and aggressive GBM tumor, including boron neutron capture therapy (BNCT).…”