Injectable hydrogels based on the hyaluronic acid and poly (γ-glutamic acid) for controlled protein delivery

Ma, Xiaofang; Xu, Tingting; Chen, Wei; Qin, Hongye; Chi, Bo; Z, Ye

doi:10.1016/j.carbpol.2017.09.071

Cited by 101 publications

(46 citation statements)

References 44 publications

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“…There are, however, challenges related to coupling proteins to HA while preserving the protein's conformation and activity [125]. Proteins such as BSA can be released in a sustainable way from HA-based hydrogels for up to 30 h without having any cytotoxicity that can meet the needs of safe cartilage repair operation practices [126]. Note that cartilage repair and regeneration is a treatment for joints that have damaged cartilage but are otherwise healthy.…”

Section: Summary and Perspectivesmentioning

confidence: 99%

Hyaluronic Acid and Controlled Release: A Review

2020

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Hyaluronic acid (HA) also known as hyaluronan, is a natural polysaccharide—an anionic, non-sulfated glycosaminoglycan—commonly found in our bodies. It occurs in the highest concentrations in the eyes and joints. Today HA is used during certain eye surgeries and in the treatment of dry eye disease. It is a remarkable natural lubricant that can be injected into the knee for patients with knee osteoarthritis. HA has also excellent gelling properties due to its capability to bind water very quickly. As such, it is one the most attractive controlled drug release matrices and as such, it is frequently used in various biomedical applications. Due to its reactivity, HA can be cross-linked or conjugated with assorted bio-macromolecules and it can effectively encapsulate several different types of drugs, even at nanoscale. Moreover, the physiological significance of the interactions between HA and its main membrane receptor, CD44 (a cell-surface glycoprotein that modulates cell–cell interactions, cell adhesion and migration), in pathological processes, e.g., cancer, is well recognized and this has resulted in an extensive amount of studies on cancer drug delivery and tumor targeting. HA acts as a therapeutic but also as a tunable matrix for drug release. Thus, this review focuses on controlled or sustained drug release systems assembled from HA and its derivatives. More specifically, recent advances in controlled release of proteins, antiseptics, antibiotics and cancer targeting drugs from HA and its derivatives were reviewed. It was shown that controlled release from HA has many benefits such as optimum drug concentration maintenance, enhanced therapeutic effects, improved efficiency of treatment with less drug, very low or insignificant toxicity and prolonged in vivo release rates.

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Section: Summary and Perspectivesmentioning

confidence: 99%

Hyaluronic Acid and Controlled Release: A Review

2020

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“…Physical gelling of ploxamer with a chemical crosslinking agent has been used to improve mechanical properties to trap cells. Also, temperature-sensitive and injectable hydrogel of hyaluronic acid has been considered by researchers due to its high biocompatibility and high sensitivity to body temperature [24]. pH-dependent methods: It should be utilized as a hydrogel stimulant because every position of the human body is related to a specific pH [15].…”

Section: Temperature Dependent Methodsmentioning

confidence: 99%

“…As shown in Figure 2 when the NH2 / CHO molar ratio reached 1: 2, the swelling rate was about twice that of the 2: 1 hydrogel, and when it was 1: 3 NH2 / CHO, due to the low rate. Cross-linking in Am J Biomed Sci & Res structure, hydrogel was dissolved in buffer phosphate salt solution (PBS) [24].…”

Section: Swelling Of Hydrogelmentioning

confidence: 99%

A Review of Hydrogels, Their Properties and Applications in Medicine

Chamkouri

2021

AJBSR

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“…The controlled release of BSA as a biological compound with a variety of composition ratios was confirmed after 30 h during either diffusion or case-II relaxation mechanisms. 203 Temperature and pH-responsive hydrogels based on poly (NIPAAm-co-poly (γ-glutamic acid) -Allyl glycidyl ether) (poly (NIPAAm-co-γ-PGA -AGE)) were synthesized by crosslinking polymerization to evaluate the controlled release of naproxen. In this study, γ-PGA-Allyl glycidyl ether (γ-PGA-AGE), which was obtained by the reaction of γ-PGA and AGE through ring-opening grafting, played an indispensable role in preparing the thermo/pH-sensitive NIPAAm-co-γ-PGA -AGE hydrogels.…”

Section: Applications Of Pga Blends For Cddssmentioning

confidence: 99%

<p>Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review</p>

Maghsoudi¹,

Shahraki²,

Rabiee³

et al. 2020

IJN

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With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds come with a number of effective benefits for improving problems of targeted or controlled drug and gene delivery systems; thus, they have been extensively used in medical and pharmaceutical applications. Additionally, they are quite attractive for wound dressings, textiles, tissue engineering, and biomedical prostheses. In this sense, some important and workable natural polymers (namely, chitosan (CS), starch and cellulose) and some applicable synthetic ones (such as poly-lactic-co-glycolic acid (PLGA), poly(lactic acid) (PLA) and poly-glycolic acid (PGA)) have played an indispensable role over the last two decades for their therapeutic effects owing to their appealing and renewable biological properties. According to our data, this is the first review article highlighting CDDSs composed of diverse natural and synthetic nano biopolymers, blended for biological purposes, mostly over the past five years; other reviews have just briefly mentioned the use of such blended polymers. We, additionally, try to make comparisons between various nano blending systems in terms of improved sustained and controlled drug release behavior.

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Injectable hydrogels based on the hyaluronic acid and poly (γ-glutamic acid) for controlled protein delivery

Cited by 101 publications

References 44 publications

Hyaluronic Acid and Controlled Release: A Review

Hyaluronic Acid and Controlled Release: A Review

A Review of Hydrogels, Their Properties and Applications in Medicine

<p>Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review</p>

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