Injectable hydrogel loaded with paclitaxel and epirubicin to prevent postoperative recurrence and metastasis of breast cancer

Leng, Qingqing; Li, Yue; Zhou, Ping; Xiong, Kang; Lü, Yun; Cui, Yongxia; Wang, Biqiong; Wu, Zhi‐Ying; Zhao, Ling; Fu, Shaozhi

doi:10.1016/j.msec.2021.112390

Cited by 38 publications

(28 citation statements)

References 43 publications

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“…Self-healing injectable hydrogels are able to spatially confine therapeutics and release them locally in a sustained manner, thereby maximizing therapeutic effects and minimizing off-target side effects. The use of injectable hydrogels for delivery of chemotherapeutics − or nanoparticles − has been investigated for various types of cancer. Intratumoral administration of chemotherapeutics using a hydrogel matrix prolongs their therapeutic efficacy compared to free drug administration and allows sustained tumor growth suppression, as shown in Figure C.…”

Section: Applications Of Self-healing Injectable Hydrogels For Tissue...mentioning

confidence: 99%

Self-Healing Injectable Hydrogels for Tissue Regeneration

et al. 2022

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Biomaterials with the ability to self-heal and recover their structural integrity offer many advantages for applications in biomedicine. The past decade has witnessed the rapid emergence of a new class of self-healing biomaterials commonly termed injectable, or printable in the context of 3D printing. These self-healing injectable biomaterials, mostly hydrogels and other soft condensed matter based on reversible chemistry, are able to temporarily fluidize under shear stress and subsequently recover their original mechanical properties. Self-healing injectable hydrogels offer distinct advantages compared to traditional biomaterials. Most notably, they can be administered in a locally targeted and minimally invasive manner through a narrow syringe without the need for invasive surgery. Their moldability allows for a patient-specific intervention and shows great prospects for personalized medicine. Injected hydrogels can facilitate tissue regeneration in multiple ways owing to their viscoelastic and diffusive nature, ranging from simple mechanical support, spatiotemporally controlled delivery of cells or therapeutics, to local recruitment and modulation of host cells to promote tissue regeneration. Consequently, self-healing injectable hydrogels have been at the forefront of many cutting-edge tissue regeneration strategies. This study provides a critical review of the current state of self-healing injectable hydrogels for tissue regeneration. As key challenges toward further maturation of this exciting research field, we identify (i) the trade-off between the self-healing and injectability of hydrogels vs their physical stability, (ii) the lack of consensus on rheological characterization and quantitative benchmarks for self-healing injectable hydrogels, particularly regarding the capillary flow in syringes, and (iii) practical limitations regarding translation toward therapeutically effective formulations for regeneration of specific tissues. Hence, here we (i) review chemical and physical design strategies for self-healing injectable hydrogels, (ii) provide a practical guide for their rheological analysis, and (iii) showcase their applicability for regeneration of various tissues and 3D printing of complex tissues and organoids.

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Section: Applications Of Self-healing Injectable Hydrogels For Tissue...mentioning

confidence: 99%

Self-Healing Injectable Hydrogels for Tissue Regeneration

et al. 2022

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Section: Discussionmentioning

confidence: 99%

“…EPI is an anthracycline drug that has been widely used in the clinical treatment of NSCLC, breast, liver, and stomach cancer (10,11,13,23). EPI inhibits the proliferation of cells by embedding itself directly in the cell DNA, thus interfering with the transcription process, inhibiting mRNA synthesis and topoisomerase II activity, and producing oxygen and free radicals (10,12). As a traditional chemotherapy drug, EPI has a significant effect in the adjuvant treatment of early breast cancer, mainly by inhibiting the metastasis of breast cancer cells, thus improving the prognosis of patients with breast cancer (10,24).…”

Section: Discussionmentioning

confidence: 99%

“…EPI inhibits the proliferation of cells by embedding itself directly in the cell DNA, thus interfering with the transcription process, inhibiting mRNA synthesis and topoisomerase II activity, and producing oxygen and free radicals (10,12). As a traditional chemotherapy drug, EPI has a significant effect in the adjuvant treatment of early breast cancer, mainly by inhibiting the metastasis of breast cancer cells, thus improving the prognosis of patients with breast cancer (10,24). EPI is less cardiotoxic than other adriamycin drugs, and when combined with trastuzumab, paclitaxel, and other chemotherapy drugs, it can significantly improve the clinical efficacy of tumor treatment (12,13).…”

Section: Discussionmentioning

confidence: 99%

“…Epirubicin (EPI) is a traditional anthracycline chemotherapy agent that has minimal side effects and thus has been widely used in the clinical treatment of breast, liver, and gastric, and non-small cell lung cancer (NSCLC) (10,11). EPI inhibits the proliferation of tumor cells by interfering with the DNA transcription process and inhibiting the synthesis of DNA and messenger RNA (12).…”

Section: Introductionmentioning

confidence: 99%

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Tailoring Hyaluronic Acid Hydrogels for Biomedical Applications

Luo,

Wang,

et al. 2023

Adv Funct Materials

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Hyaluronic acid (HA) is an attractive anionic polysaccharide polymer with inherent pharmacological properties and versatile chemical groups for modification. Due to their water retention ability, biocompatibility, biodegradation, cluster of differentiation‐44 targeting, and highly designable capacity, HA hydrogels have been an emerging biomaterial, showing tailoring performance in terms of chemical modifications and hydrogel forms. Various preparation technologies have been developed for the fabrication of the tailoring HA hydrogels with unique structures and functions. They have been utilized in diverse biomedical applications like drug delivery and tissue engineering scaffolds. Herein, this review comprehensively summarizes the HA derivatives with different molecule weights and functional modifications. Then the various fabrication methods to obtain tailoring hydrogels in the forms of nanogel, nanofiber, microparticle, microneedle patch, injectable hydrogel, and scaffold are reviewed as well. The emphasis is focused on the shining biomedical applications of these tailoring HA hydrogels in anti‐bacteria, anti‐inflammation, wound healing, cancer treatment, regenerative medicine, psoriasis treatment, diagnosis, etc. The potentials and prospects are subsequently given to inspire further investigation, aiming at accelerating product translation from research to clinic.

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Injectable hydrogel loaded with paclitaxel and epirubicin to prevent postoperative recurrence and metastasis of breast cancer

Cited by 38 publications

References 43 publications

Self-Healing Injectable Hydrogels for Tissue Regeneration

Self-Healing Injectable Hydrogels for Tissue Regeneration

Image_1.pdf

Tailoring Hyaluronic Acid Hydrogels for Biomedical Applications

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