Injectable hydrogel for postoperative synergistic photothermal-chemodynamic tumor and anti-infection therapy

Huang, Han; Wang, Xiaorui; Wang, Weili; Qu, Xinyu; Song, Xuejiao; Zhang, Yewei; Zhong, Liping; Yang, Da‐Peng; Dong, Xiaochen; Zhao, Yongxiang

doi:10.1016/j.biomaterials.2021.121289

Cited by 76 publications

(38 citation statements)

References 51 publications

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“…It is well known that an increase in collagen contributes to wound healing during the early stage, while excessive and persistent collagen deposition causes scar tissue formation, affecting skin repair. [ 52 ] Thus, we also performed Masson staining experiments to assess collagen deposition and the healing level of skin in each group. As illustrated in Figure 10F , the collagen deposition in the Gel‐S‐A group dramatically increased during the early stage but declined in the late stage, and this trend was the most prominent in the Gel‐S‐A group among all the groups.…”

Section: Resultsmentioning

confidence: 99%

An Injectable Epigenetic Autophagic Modulatory Hydrogel for Boosting Umbilical Cord Blood NK Cell Therapy Prevents Postsurgical Relapse of Triple‐Negative Breast Cancer

Gong

Chen

et al. 2022

Advanced Science

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Triple‐negative breast cancer (TNBC) exhibits resistance to conventional treatments due to the presence of cancer stem cells (CSCs), causing postsurgical relapse and a dismal prognosis. Umbilical cord blood natural killer (UCB‐NK) cell‐based immunotherapy represents a promising strategy for cancer treatment. However, its therapeutic efficacy is greatly restrained by downregulation of the NK cell activation ligand MHC class I‐related chain A/B (MICA/B) and autophagy‐mediated degradation of NK cell‐derived granzyme B (GZMB) in CSCs. Herein, it is demonstrated that suberoylanilide hydroxamic acid (SAHA) epigenetically downregulates let‐7e‐5p and miR‐615‐3p to increase MICA/B expression and that 3‐methyl adenine (3MA) inhibits autophagy‐mediated GZMB degradation, thereby sensitizing breast CSCs to UCB‐NK cells. Then, an injectable hydrogel is designed to codeliver SAHA and 3MA to enhance UCB‐NK cell infusion efficacy in TNBC. The hydrogel precursors can be smoothly injected into the tumor resection bed and form a stable gel in situ, allowing for a pH‐sensitive sustained release of SAHA and 3MA. Moreover, UCB‐NK cell infusion in combination with the hydrogel efficiently controls postsurgical relapse of TNBC. In addition, the hydrogel exhibits good hemostasis and wound‐healing functions. Therefore, the work provides proof of concept that an injectable epigenetic autophagic modulatory hydrogel augments UCB‐NK cell therapy to combat postsurgical relapse of TNBC.

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Section: Resultsmentioning

confidence: 99%

An Injectable Epigenetic Autophagic Modulatory Hydrogel for Boosting Umbilical Cord Blood NK Cell Therapy Prevents Postsurgical Relapse of Triple‐Negative Breast Cancer

Gong

Chen

et al. 2022

Advanced Science

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“…Huang etal. ( 287 ) mixed Ag 2 S nanodot-conjugated Fe-doped bioactive glass nanoparticles (BGN-Fe-Ag 2 S) with PEG double acrylates (PEGDA) and 2,2′-azobis[2-(2-imidazolin-2-yl)propane]-dihydrochloride solution to form a novel light-activated injectable nano-hydrogel (PBFA). The results of in vitro experiments showed that under the irradiation of an 808-nm laser, the solution temperature of the PBFA group increased significantly, the concentration of intracellular ROS increased, and the survival rate of tumor cells was much lower than that of the control groups at 33%.…”

Section: Multimodal Therapy For Tumors Based On Photothermal Nanomate...mentioning

confidence: 99%

Research Progress of Photothermal Nanomaterials in Multimodal Tumor Therapy

et al. 2022

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The aggressive growth of cancer cells brings extreme challenges to cancer therapy while triggering the exploration of the application of multimodal therapy methods. Multimodal tumor therapy based on photothermal nanomaterials is a new technology to realize tumor cell thermal ablation through near-infrared light irradiation with a specific wavelength, which has the advantages of high efficiency, less adverse reactions, and effective inhibition of tumor metastasis compared with traditional treatment methods such as surgical resection, chemotherapy, and radiotherapy. Photothermal nanomaterials have gained increasing interest due to their potential applications, remarkable properties, and advantages for tumor therapy. In this review, recent advances and the common applications of photothermal nanomaterials in multimodal tumor therapy are summarized, with a focus on the different types of photothermal nanomaterials and their application in multimodal tumor therapy. Moreover, the challenges and future applications have also been speculated.

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“…Lactic acid affects a number of cellular activities inside the TME as an energy source, signaling molecule, and key tumor immunosuppressive factor [ 8 ]. A weak acidic environment in the extracellular pH of TME is caused by cancer cells' excessive use of glucose, resulting in a buildup of lactic acid, which in turn promotes tumor spreading, angiogenesis, treatment resistance, and immune suppression [ 11 – 13 ]. Meanwhile, lactic acid generation reduces the ability of NK and NKT cells to fight cancer, which promotes tumor growth [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Tumor Microenvironment: Lactic Acid Promotes Tumor Development

Gao

Zhou

Liu

et al. 2022

Journal of Immunology Research

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Lactic acid is a “metabolic waste” product of glycolysis that is produced in the body. However, the role of lactic acid in the development of human malignancies has gained increasing interest lately as a multifunctional small molecule chemical. There is evidence that tumor cells may create a large amount of lactic acid through glycolysis even when they have abundant oxygen. Tumor tissues have a higher quantity of lactic acid than normal tissues. Lactic acid is required for tumor development. Lactate is an immunomodulatory chemical that affects both innate and adaptive immune cells’ effector functions. In immune cells, the lactate signaling pathway may potentially serve as a link between metabolism and immunity. Lactate homeostasis is significantly disrupted in the TME. Lactate accumulation results in acidosis, angiogenesis, immunosuppression, and tumor cell proliferation and survival, all of which are deleterious to health. Thus, augmenting anticancer immune responses by lactate metabolism inhibition may modify lactate levels in the tumor microenvironment. This review will evaluate the role of lactic acid in tumor formation, metastasis, prognosis, treatment, and histone modification. Our findings will be of considerable interest to readers, particularly those engaged in the therapeutic treatment of cancer patients. Treatments targeting the inhibition of lactate synthesis and blocking the source of lactate have emerged as a potential new therapeutic option for oncology patients. Additionally, lactic acid levels in the plasma may serve as biomarkers for disease stage and may be beneficial for evaluating therapy effectiveness in individuals with tumors.

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Injectable hydrogel for postoperative synergistic photothermal-chemodynamic tumor and anti-infection therapy

Cited by 76 publications

References 51 publications

An Injectable Epigenetic Autophagic Modulatory Hydrogel for Boosting Umbilical Cord Blood NK Cell Therapy Prevents Postsurgical Relapse of Triple‐Negative Breast Cancer

An Injectable Epigenetic Autophagic Modulatory Hydrogel for Boosting Umbilical Cord Blood NK Cell Therapy Prevents Postsurgical Relapse of Triple‐Negative Breast Cancer

Research Progress of Photothermal Nanomaterials in Multimodal Tumor Therapy

Tumor Microenvironment: Lactic Acid Promotes Tumor Development

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