Injectable chitosan-based hydrogels for cartilage tissue engineering

Hydrogels for the Repair of Articular Cartilage Defects

“…90,92 Chitosan has been modified to increase biochemical similarity to cartilage 85,88,94,112 and to prepare injectable scaffolds. [84][85][86]91,95 Chondrocytes encapsulated in injectable chitosan hydrogels repaired non-weightbearing defects in sheep, with good integration with the surrounding tissue. 86 In situ-gelling hydrogels based on chitosan and glycerol phosphate (BST-CarGel; Biosyntech, Quebec, Canada) mixed with blood repaired 1 cm 3 weightbearing cartilage defects in sheep with more hyaline cartilage than microfracture controls.…”

Protease-sensitive atelocollagen hydrogels promote healing in a diabetic wound model

“…46 Dry, freshly synthesised, atelo-and rat tail collagen networks of known weight (md) were equilibrated in 10 mM HCl solution for 24 hour. Resulting hydrogels were air dried and weighed.…”

In-Situ Forming Biomimetic Hydrogels for Tissue Regeneration

“…The gelation rates induced by enzyme-mediated crosslinking can be readily adjusted from minutes to seconds by varying the HRP concentrations. By the same approach, Jin and Lee et al prepared the chitosan-phloretic acid and hyaluronic acid-tyramine hydrogels for cartilage tissue engineering (Jin et al, 2009) and protein delivery applications (F. , respectively. The disadvantage of this approach is the use of hydrogen peroxide.…”