Injectable bone cement based on mineralized collagen

Liu, Xi; Wang, Xiumei; Chen, Zonggang; Cui, Fuzhai; Liu, Huanye; Mao, Keya; Wang, Yan

doi:10.1002/jbm.b.31625

Cited by 38 publications

(32 citation statements)

References 34 publications

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“…Furthermore, collagen might be incorporated into various calcium orthophosphate cements. 713,738,[760][761][762][763][764] Typically, a type I collagen sponge is presoaked in a PO 4 3--containing, highly basic aqueous solution and then immersed into a Ca 2+ -containing solution to allow mineral deposition. Alternatively, collagen I fibers might be dissolved in acetic acid, then this solution added to phosphoric acid, followed by a neutralization synthesis (performed at 25°C and solution pH within 9-10) between an aqueous suspension of Ca(OH) 2 and the H 3 PO 4 /collagen solution.…”

mentioning

confidence: 99%

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Dorozhkin¹

2011

Biomatter

153

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confidence: 99%

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Dorozhkin¹

2011

Biomatter

153

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“…The initial setting duration for the n-CDHA/MAC/CSH composites containing different proportions of n-CDHA/MAC varies from 10 to 30 minutes, which is consistent with previous studies. 19,25 In contrast, the initial setting time for pure CSH is as short as 5 minutes. Clinically, the initial setting time of bone cements should be ideally controlled between 15-25 minutes.…”

Section: Discussionmentioning

confidence: 99%

Development and characterization of an injectable cement of nano calcium-deficient hydroxyapatite/multi(amino acid) copolymer/calcium sulfate hemihydrate for bone repair

Qi¹,

Hong²,

Qiao³

et al. 2013

IJN

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A novel injectable bone cement was developed by integration of nano calcium-deficient hydroxyapatite/multi(amino acid) copolymer (n-CDHA/MAC) and calcium sulfate hemihydrate (CSH; CaSO 4 · 1/2H 2 O). The structure, setting time, and compressive strength of the cement were investigated. The results showed that the cement with a liquid to powder ratio of 0.8 mL/g exhibited good injectability and appropriate setting time and mechanical properties. In vitro cell studies indicated that MC3T3-E1 cells cultured on the n-CDHA/MAC/CSH composite spread well and showed a good proliferation state. The alkaline phosphatase activity of the MC3T3-E1 cells cultured on the n-CDHA/MAC/CSH composite was significantly higher than that of the cells on pure CSH at 4 and 7 days of culture. The n-CDHA/MAC/CSH cement was implanted into critical size defects of the femoral condyle in rabbits to evaluate its biocompatibility and osteogenesis in vivo. Radiological and histological results indicated that introduction of the n-CDHA/MAC into CSH enhanced new bone formation, and the n-CDHA/MAC/CSH cement exhibited good biocompatibility and degradability. In conclusion, the injectable n-CDHA/MAC/CSH composite cement has a significant clinical advantage over pure CSH cement, and may be a promising bone graft substitute for the treatment of bone defects.

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“…61 To control the degradation rate of CSC, Liu et al studied degradation of a nanocrystalline HA/CSH composite and showed that addition of 30 wt% HA nanocrystals to CSH had a significant effect on the degradation rate of the composite cement. 62 …”

Section: Calcium Sulfate Cementmentioning

confidence: 99%

Nanotechnology for treating osteoporotic vertebral fractures

Gao¹,

Wei²,

Yang³

et al. 2015

IJN

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Osteoporosis is a serious public health problem affecting hundreds of millions of aged people worldwide, with severe consequences including vertebral fractures that are associated with significant morbidity and mortality. To augment or treat osteoporotic vertebral fractures, a number of surgical approaches including minimally invasive vertebroplasty and kyphoplasty have been developed. However, these approaches face problems and difficulties with efficacy and long-term stability. Recent advances and progress in nanotechnology are opening up new opportunities to improve the surgical procedures for treating osteoporotic vertebral fractures. This article reviews the improvements enabled by new nanomaterials and focuses on new injectable biomaterials like bone cements and surgical instruments for treating vertebral fractures. This article also provides an introduction to osteoporotic vertebral fractures and current clinical treatments, along with the rationale and efficacy of utilizing nanomaterials to modify and improve biomaterials or instruments. In addition, perspectives on future trends with injectable bone cements and surgical instruments enhanced by nanotechnology are provided.

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Injectable bone cement based on mineralized collagen

Cited by 38 publications

References 34 publications

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Development and characterization of an injectable cement of nano calcium-deficient hydroxyapatite/multi(amino acid) copolymer/calcium sulfate hemihydrate for bone repair

Nanotechnology for treating osteoporotic vertebral fractures

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