Injectable biodegradable hydrogels: progress and challenges

Bae, Ki Hyun; Wang, Lishan; Kurisawa, Motoichi

doi:10.1039/c3tb20940g

Cited by 260 publications

(195 citation statements)

References 195 publications

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“…Гидроге-ли можно разделить на два типа в соответствии с методами их получения: предварительно сформиро-ванные гидрогели и формируемые in situ гидрогели. В частности, формируемые in situ гидрогели при-влекают значительное внимание как искусственная микросреда из-за простоты инкапсуляции клеток, сигнальных молекул или лекарственных субстан-ций в процессе формирования гидрогеля [7]. Для создания формируемых in situ гидрогелей использу-ются различные природные, синтетические и полу-синтетические полимеры, включая полисахариды, белки, синтетические полимеры и их производные [8].…”

Section: Introductionunclassified

“…In particular, in situ-formed hydrogels have received considerable attention as artificial cellular microenvironments because of ease of encapsulation of the cells or signaling molecules during hydrogel formation [7] Various natural, synthetic, and semisynthetic polymers have been utilized to create the in situforming hydrogels, including polysaccharides, proteins, synthetic polymers, and their derivatives [8]. With these diverse materials, various crosslinking strategies have been developed to form polymeric networks in situ, including physical and chemical crosslinking reactions.…”

Section: Introductionmentioning

confidence: 99%

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In situ crosslinkable hydrogels for engineered cellular microenvironments

Парк

Sevastianov

et al. 2017

RJTAO

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1 Отделение биоинженерии, Колледж наук о жизни и биоинженерии, Национальный университет Инчеона, Инчеон, 22012, Республика Корея 2 Факультет молекулярной науки и технологии, Университет Ажон, Сувон 443-749, Республика Корея 3 ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, Москва, Российская Федерация Формируемые (сшиваемые) in situ гидрогели широко применяются в качестве терапевтических имплан-татов и систем доставки для различных биомедицинских технологий, включая тканевую инженерию, регенеративную медицину и фармакологию, благодаря биосовместимости гидрогелей и простоте инкор-порирования в них лекарственных веществ, клеток или сигнальных молекул в процессе образования сетчатой структуры. В последнее время гидрогелевые материалы часто используются в качестве искус-ственного внеклеточного матрикса из-за их структурного сходства с нативным внеклеточным матриксом человека, а также из-за возможности регулировать их многообразные свойства. В качестве клеточной микросреды (матриксов, носителей) на основе различных технологий сшивки был разработан ряд синте-тических, природных и полусинтетических гидрогелей. В данном обзоре обсуждаются вопросы создания формируемых in situ гидрогелей с регулируемыми физическими, химическими и биологическими свойс-твами. Будет сделан также анализ новых методов применения инновационных гидрогелевых материалов для создания клеточной микросреды как матриксов для биомедицинских тканевых продуктов, так и сис-тем доставки клеток и лекарственных веществ. In situ crosslinkable hydrogels have been widely used as therapeutic implants and vehicles for a broad range of biomedical applications including tissue regenerative medicine because of their biocompatibility and easiness of encapsulation of cells or signaling molecules during hydrogel formation. Recently, these hydrogel materials have been widely utilized as an artificial extracellular matrix (aECM) because of its structural similarity with the native extracellular matrix (ECM) of the human body and its multi-tunable properties. Various synthetic, natural, and semisynthetic hydrogels have been developed as engineered cellular microenvironments by using various crosslinking strategies. In this review, we discuss how in situ forming hydrogels are being created with tunable physical, chemical, and biological properties. In particular, we focus on emerging techniques to apply advanced hydrogel materials for engineered cellular microenvironments. ВВедеНиеПолимерные гидрогели представляют собой гид-рофильные трехмерные (3D) сетки, которые погло-щают и удерживают большое количество воды [1,2]. Эти полимерные системы широко используются в качестве терапевтических имплантатов и систем доставки для различных биомедицинских примене-ний, включая тканевую инженерию, регенератив-ную медицину и доставку лекарств [3][4][5][6]. Гидроге-ли можно разделить на два типа в соответствии с методами их получения: предварительно сформиро-ванные гидрогели и формируемые in...

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Section: Introductionunclassified

Section: Introductionmentioning

confidence: 99%

In situ crosslinkable hydrogels for engineered cellular microenvironments

Парк

Sevastianov

et al. 2017

RJTAO

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“…The polymerization of amphiphilic hydrogels under visible and UV light is interesting as the process conditions are very mild and the reaction can be carried out in direct contact with drugs, cells and tissues. Injectable hydrogels provide an effective and convenient way to administer a wide variety of bioactive agents such as proteins, genes, and even living cells [80]. Drug delivery purposes can be achieved with e.g., poly (N-isopropylacrylamide)-modified poly(2-hydroxyethyl acrylate) hydrogels [81], poly (ethylene glycol)-co-poly (e-caprolactone) diacrylate macromer and hydroxypropyl guar gum [82].…”

Section: Examples Of Final Properties For Photochemically Produced Ipnsmentioning

confidence: 99%

Photochemical Production of Interpenetrating Polymer Networks; Simultaneous Initiation of Radical and Cationic Polymerization Reactions

Fouassier

Lalevée

2014

Polymers

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Abstract:In this paper, we propose to review the ways to produce, through photopolymerization, interpenetrating polymer networks (IPN) based, e.g., on acrylate/epoxide or acrylate/vinylether blends and to outline the recent developments that allows a one-step procedure (concomitant radical/cationic polymerization), under air or in laminate, under various irradiation conditions (UV/visible/near IR; high/low intensity sources; monochromatic/polychromatic sources; household lamps/laser diodes/Light Emitting Diodes (LEDs)). The paper illustrates the encountered mechanisms and the polymerization profiles. A short survey on the available monomer systems and some brief examples of the attained final properties of the IPNs is also provided.

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“…9,10 Due to these weak cross-linking mechanisms, most of the developed biodegradable hydrogels exhibit poor mechanical properties. 11,12 In contrast, synthetic chemically cross-linked hydrogels with strong covalent bonds present an enhanced mechanical strength.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable HEMA‐based hydrogels with enhanced mechanical properties

Moghadam

Pioletti

2015

J Biomed Mater Res

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Hydrogels are widely used in the biomedical field. Their main purposes are either to deliver biological active agents or to temporarily fill a defect until they degrade and are followed by new host tissue formation. However, for this latter application, biodegradable hydrogels are usually not capable to sustain any significant load. The development of biodegradable hydrogels presenting load-bearing capabilities would open new possibilities to utilize this class of material in the biomedical field. In this work, an original formulation of biodegradable photo-crosslinked hydrogels based on hydroxyethyl methacrylate (HEMA) is presented. The hydrogels consist of short-length poly(2-hydroxyethyl methacrylate) (PHEMA) chains in a star shape structure, obtained by introducing a tetra-functional chain transfer agent in the backbone of the hydrogels. They are cross-linked with a biodegradable N,O-dimethacryloyl hydroxylamine (DMHA) molecule sensitive to hydrolytic cleavage. We characterized the degradation properties of these hydrogels submitted to mechanical loadings. We showed that the developed hydrogels undergo long-term degradation and specially meet the two essential requirements of a biodegradable hydrogel suitable for load bearing applications: enhanced mechanical properties and low molecular weight degradation products.

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Injectable biodegradable hydrogels: progress and challenges

Cited by 260 publications

References 195 publications

In situ crosslinkable hydrogels for engineered cellular microenvironments

In situ crosslinkable hydrogels for engineered cellular microenvironments

Photochemical Production of Interpenetrating Polymer Networks; Simultaneous Initiation of Radical and Cationic Polymerization Reactions

Biodegradable HEMA‐based hydrogels with enhanced mechanical properties

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