Injectable and tissue adhesive EGCG-laden hyaluronic acid hydrogel depot for treating oxidative stress and inflammation

He, Zhichao; Luo, Huitong; Wang, Zetao; Chen, Dafu; Feng, Qi; Cao, Xiaodong

doi:10.1016/j.carbpol.2022.120180

Cited by 42 publications

(28 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the past decade, HA and its derivatives have found use in different biomedical applications because of their hydrophilicity, biocompatibility, and viscoelastic properties, and they are considered important components of synthetic scaffolds for the delivery of drugs and genes [ 89 ]. In this context, He et al recently designed a tissue-adhesive hydrogel depot able to achieve anti-inflammatory and anti-oxidative effects [ 53 ]. The matrix consisted of methacrylic acid and 3-aminophenylboronic acid grafted to HA.…”

Section: Natural Hydrogelsmentioning

confidence: 99%

“…Photoinitiation radical polymerization improved the mechanical properties of the HA/Gel hydrogel and drastically reduced the burst release of EGCG. The pH responsiveness due to phenylboronic acid ester formation was evaluated, showing a higher cumulative release amount of EGCG at an acidic pH compared to a neutral pH, allowing us to consider the designed matrix as a possible treatment for oxidative stress and inflammation [ 53 ].…”

Section: Natural Hydrogelsmentioning

confidence: 99%

See 1 more Smart Citation

Polysaccharide-Based Hydrogels and Their Application as Drug Delivery Systems in Cancer Treatment: A Review

Dattilo

Patitucci

Prete

et al. 2023

JFB

View full text Add to dashboard Cite

Hydrogels are three-dimensional crosslinked structures with physicochemical properties similar to the extracellular matrix (ECM). By changing the hydrogel’s material type, crosslinking, molecular weight, chemical surface, and functionalization, it is possible to mimic the mechanical properties of native tissues. Hydrogels are currently used in the biomedical and pharmaceutical fields for drug delivery systems, wound dressings, tissue engineering, and contact lenses. Lately, research has been focused on hydrogels from natural sources. Polysaccharides have drawn attention in recent years as a promising material for biological applications, due to their biocompatibility, biodegradability, non-toxicity, and excellent mechanical properties. Polysaccharide-based hydrogels can be used as drug delivery systems for the efficient release of various types of cancer therapeutics, enhancing the therapeutic efficacy and minimizing potential side effects. This review summarizes hydrogels’ classification, properties, and synthesis methods. Furthermore, it also covers several important natural polysaccharides (chitosan, alginate, hyaluronic acid, cellulose, and carrageenan) widely used as hydrogels for drug delivery and, in particular, their application in cancer treatment.

show abstract

Section: Natural Hydrogelsmentioning

confidence: 99%

Section: Natural Hydrogelsmentioning

confidence: 99%

Polysaccharide-Based Hydrogels and Their Application as Drug Delivery Systems in Cancer Treatment: A Review

Dattilo

Patitucci

Prete

et al. 2023

JFB

View full text Add to dashboard Cite

show abstract

“…Due to the lack of vascularization in the intervertebral disc (IVD), various in situ injectable platforms such as microspheres, 19,20 nanocarriers 29,30 and hydrogels 31–34 loaded with anti-inflammatory drugs have been developed for minimally invasive treatment of IVDD. With tunable mechanical and chemical properties, hydrogels rival or exceed other platforms.…”

Section: Introductionmentioning

confidence: 99%

“…With tunable mechanical and chemical properties, hydrogels rival or exceed other platforms. [34][35][36][37] However, the rapid degradation rate of the pure CS scaffold limits its persistent functioning. 38 The hydrogel with sustained and stimulus-responsive CS release property turns to be another choice for CS to effectuate anti-inflammation in target tissues.…”

Section: Introductionmentioning

confidence: 99%

Injectable chondroitin sulfate-grafted self-antioxidant hydrogels ameliorate nucleus pulposus degeneration against overactive inflammation

Luo

Wang

et al. 2023

Biomater. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Hydrogels based on phenylboronic acid-diol interaction have attracted attention due to their ability to form ROS-responsive drug bridging linkers with catechin-like polyphenols to prevent irreversible oxidation and low bioavailability or biotoxicity caused by the uncontrolled release of drugs. , TA is a plant-derived polyphenol with abundant phenolic hydroxyl groups and is considered as an anti-inflammatory, antimicrobial, and antioxidant agent . Various TA-doped hydrogels have been developed as wound dressings, tissue adhesives, and hemostatic sealants. ,, …”

Section: Introductionmentioning

confidence: 99%

Multistage ROS-Responsive and Natural Polyphenol-Driven Prodrug Hydrogels for Diabetic Wound Healing

Huang

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

The high level of reactive oxygen species (ROS) and bacterial infection impede wound healing of the diabetic wound. Here, benefiting from the antioxidation effects of tannic acid (TA) and ROS-responsive phenylborate ester (PBAE), a series of ROS-responsive anti-inflammatory TA-conjugated nanoparticle hydrogels (PPBA-TA-PVA) can be obtained by conveniently mixing TA, phenylboric acid modified polyphosphazene (PPBA), and poly(vinyl alcohol) (PVA). The obtained PPBA-TA-PVA hydrogels could effectively inhibit the growth of Escherichia coli (antibacterial rate = 93.1 ± 1.1%) within 4 h and effectively scavenge both 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and •OH radicals in vitro. Besides, the cell migration rate of HDFa cells treated with PPBA-TA-PVA hydrogels (84.2 ± 4.6%) was twice the rate of normal cells (43.8 ± 8.1%) after 24 h of cocultivation. The clinical relevance was demonstrated further by assessing the PPBA-TA-PVA hydrogels in full-thickness excisional wounds in a streptozotocin (STZ)-induced diabetic rat model. The PPBA-TA-PVA hydrogels could act as effective ROS-scavenging agents to alleviate inflammation and accelerate wound closure by decreasing the proinflammatory cytokines (IL-6, IL-1β) and increasing the gene expression of TGF-β1, COL-1, and COL-3, which resulted in faster re-epithelialization and increased formation of granulation tissue.

show abstract

Injectable and tissue adhesive EGCG-laden hyaluronic acid hydrogel depot for treating oxidative stress and inflammation

Cited by 42 publications

References 53 publications

Polysaccharide-Based Hydrogels and Their Application as Drug Delivery Systems in Cancer Treatment: A Review

Polysaccharide-Based Hydrogels and Their Application as Drug Delivery Systems in Cancer Treatment: A Review

Injectable chondroitin sulfate-grafted self-antioxidant hydrogels ameliorate nucleus pulposus degeneration against overactive inflammation

Multistage ROS-Responsive and Natural Polyphenol-Driven Prodrug Hydrogels for Diabetic Wound Healing

Contact Info

Product

Resources

About