Injectable Adhesive Hydrogel through a Microcapsule Cross-Link for Periodontitis Treatment

Dong, Zejun; Sun, Yining; Chen, Yuhui; Yan, Liu; Tang, Chuhua; Qu, Xiaozhong

doi:10.1021/acsabm.9b00912

Cited by 33 publications

(42 citation statements)

References 42 publications

(68 reference statements)

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“…Such systems are sensitive to the pH, counter ion/polymer ratio, and temperature. [27] For example, alginate is crosslinked by the counterion Ca 2+ , [28][29][30][31][32] and cationic residues of polypeptides can be crosslinked using anionic organophosphorus crosslinkers. [33] Some examples of oppositely charged polymer-polymer crosslinking are the ionic crosslinking of quaternized chitosan (CS) with glycerophosphate [34] or chitosan and polyglutamate.…”

Section: Physically Crosslinked Injectable Hydrogelsmentioning

confidence: 99%

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Rizzo

Kehr

2020

Adv Healthcare Materials

183

152

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Injectable hydrogels have received considerable interest in the biomedical field due to their potential applications in minimally invasive local drug delivery, more precise implantation, and site‐specific drug delivery into poorly reachable tissue sites and into interface tissues, where wound healing takes a long time. Injectable hydrogels, such as in situ forming and/or shear‐thinning hydrogels, can be generated using chemically and/or physically crosslinked hydrogels. Yet, for controlled and local drug delivery applications, the ideal injectable hydrogel should be able to provide controlled and sustained release of drug molecules to the target site when needed and should limit nonspecific drug molecule distribution in healthy tissues. Thus, such hydrogels should sense the environmental changes that arise in disease states and be able to release the optimal amount of drug over the necessary time period to the target region. To address this, researchers have designed stimuli‐responsive injectable hydrogels. Stimuli‐responsive hydrogels change their shape or volume when they sense environmental stimuli, e.g., pH, temperature, light, electrical signals, or enzymatic changes, and deliver an optimal concentration of drugs to the target site without affecting healthy tissues.

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Section: Physically Crosslinked Injectable Hydrogelsmentioning

confidence: 99%

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Rizzo

Kehr

2020

Adv Healthcare Materials

183

152

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“…This delivery system was quite effective in anti-inflammation and periodontium regeneration [150]. In other research, Dong et al reported a thermoresponsive injectable PVA based hydrogel to control the release rate of antibiotics [151]. The sustained release of the drug endowed a prolonged bacteriostatic ability, while Chitosan decorated metronidazole (MTZ) enhanced the injectability and bio-adhesive property of the hydrogel [151].…”

Section: Periodontal Regenerationmentioning

confidence: 99%

Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Askari

Seyfoori

Amereh

et al. 2020

Gels

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Currently, surgical operations, followed by systemic drug delivery, are the prevailing treatment modality for most diseases, including cancers and trauma-based injuries. Although effective to some extent, the side effects of surgery include inflammation, pain, a lower rate of tissue regeneration, disease recurrence, and the non-specific toxicity of chemotherapies, which remain significant clinical challenges. The localized delivery of therapeutics has recently emerged as an alternative to systemic therapy, which not only allows the delivery of higher doses of therapeutic agents to the surgical site, but also enables overcoming post-surgical complications, such as infections, inflammations, and pain. Due to the limitations of the current drug delivery systems, and an increasing clinical need for disease-specific drug release systems, hydrogels have attracted considerable interest, due to their unique properties, including a high capacity for drug loading, as well as a sustained release profile. Hydrogels can be used as local drug performance carriers as a means for diminishing the side effects of current systemic drug delivery methods and are suitable for the majority of surgery-based injuries. This work summarizes recent advances in hydrogel-based drug delivery systems (DDSs), including formulations such as implantable, injectable, and sprayable hydrogels, with a particular emphasis on stimuli-responsive materials. Moreover, clinical applications and future opportunities for this type of post-surgery treatment are also highlighted.

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“…Dong and co-workers have prepared an injectable hydrogel system based on poly(vinyl alcohol) (PVA) with metronidazole (MTZ) microcapsules (CS-MTZ) incorporated in chitosan (CS) ( Figure 6 ) [ 17 ]. To obtain a crosslinked hydrogel, they have used a dually dynamic crosslinking strategy with 4-carboxyphenylboronic acid (CPBA).…”

Section: Hydrogelsmentioning

confidence: 99%

“… Schematic illustration of the preparation of chitosan-loaded metronidazole microcapsules (CS@MTZ) and the cross-linking mechanism with CPBA-grafted PVA to obtain injectable hydrogel. Reprinted with permission from [ 17 ]. Copyright ACS Publications (2019).…”

Section: Figurementioning

confidence: 99%

“…It is worth mentioning that local sustained administration of drugs into the periodontal pockets in the mouth is challenging due to the continuous secretion of saliva. This facilitates for the implant to leave the periodontal pocket easily and it could then be swallowed by the patient [ 17 ]. Usage of a local drug delivery system in the treatment of periodontitis allows to achieve and maintain a greater concentration of drug at the diseased area than possible with conventional therapy, preventing the side effects of free-drugs.…”

Section: Introductionmentioning

confidence: 99%

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Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

et al. 2020

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Periodontitis (PD) is a chronic inflammatory disease of periodontal tissues caused by pathogenic microorganisms and characterized by disruption of the tooth-supporting structures. Conventional drug administration pathways in periodontal disease treatment have many drawbacks such as poor biodistribution, low selectivity of the therapeutic effect, burst release of the drug, and damage to healthy cells. To overcome this limitation, controlled drug delivery systems have been developed as a potential method to address oral infectious disease ailments. The use of drug delivery devices proves to be an excellent auxiliary method in improving the quality and effectiveness in periodontitis treatment, which includes inaccessible periodontal pockets. This review explores the current state of knowledge regarding the applications of various polymer-based delivery systems such as hydrogels, liposomes, micro-, and nanoparticles in the treatment of chronic periodontal disease. Furthermore, to present a more comprehensive understanding of the difficulties concerning the treatment of PD, a brief description of the mechanism and development of the disease is outlined.

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Injectable Adhesive Hydrogel through a Microcapsule Cross-Link for Periodontitis Treatment

Cited by 33 publications

References 42 publications

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

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