Injeção epidural preventiva de xilazina ou amitraz, em eqüinos: efeito antinociceptivo

Guirro, Erica Cristina Bueno do Prado; Sobrinho, Guilherme Roberto; Ferreira, Isabella Maria Marchesini; Valadão, Carlos Augusto Araújo

doi:10.1590/s0103-84782008005000049

Cited by 2 publications

(2 citation statements)

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“…The method used to evaluate the MNT was based on the paucity of studies with mechanical models to assess the effects of amantadine in dogs. Despite not having been studied in dogs, this method has been used to determine the sensitivity with relative safety and reproducibility in horses (Rédua et al 2002;Oleoskovicz et al, 2006;Guirro et al, 2009) and in rats (Moura et al 2015;Cunha et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs

Niella

Sena

Corrêa

et al. 2020

RSD

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This study aimed to evaluate the preemptive analgesic effect of amantadine on postoperative pain control in female dogs that underwent ovariohysterectomy. Twenty female dog were randomly assigned to two groups of ten. The control group (CONTROL) received oral placebo capsules, while the amantadine (AMANT) group received 5 mg/kg of oral amantadine one hour before sedation. All the animals were premedicated with 3 mg/kg (IM) meperidine, induced with propofol and maintained with isofluorane. The transanesthetic physiological parameters were recorded, and postoperative pain was evaluated every hour after extubation for six hours with the Dynamic Interactive Visual Analog Scale (DIVAS) and mechanical nociceptive threshold (MNT) and when the necessary analgesic rescue was administered (morphine, 0.2 mg/kg (IM)). During the surgical procedure, there was no significant difference in the variables measured between the two groups. Regarding postoperative pain assessment, there was a significant difference in the DIVAS score (p = 0.004) between the groups, in which AMANT required fewer rescues than did CONTROL (p = 0.03). The MNT was significantly higher in AMANT than in CONTROL (p = 0.03). The results suggested that the preoperative administration of amantadine decreased analgesic requirement in female dogs that underwent elective ovariohysterectomy.

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Section: Discussionmentioning

confidence: 99%

Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs

Niella

Sena

Corrêa

et al. 2020

RSD

View full text Add to dashboard Cite

show abstract

“…In other moments when there was a difference between the groups of two drugs, it was possible to observe that, when using the lower doses of detomidine, the nose-ground distance was similar to that observed with the greater doses of xylazine, showing that detomidine resulted in a more intense sedation due to its greater selectivity regarding adrenoceptors when compared to xylazine (Hubbell et al, 2012). Xylazine has a selectivity ratio of 160 (Guirro et al, 2009) and detomidine of 260 (Fischer et al, 2009) between α-2/α-1 receptors, thus detomidine has similar action to xylazine, but with ten times the potency and longer lasting effects (Hubbell et al, 2012). a, b = different letters indicate a significant difference between groups (p<0.05).…”

Section: Resultsmentioning

confidence: 66%