Initiation of reticular and spider veins, incompetent perforantes and varicose veins in the saphenous vein network of the rat

Patai, Bernadett Bettina; Dörnyei, Gabriella; Tőkés, Anna-Mária; Hetthéssy, Judit; Fees, Alexander; Nádasy, György L.

doi:10.1038/s41598-020-71982-z

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…Под вену подводили филамент диаметром 450 мкм и перевязывали полиамидной нитью, что позволяло достичь частичной стриктуры глубокой бедренной вены. Далее рану ушивали и обрабатывали раствором 10% повидон-йода [6]. 2023 20(1):166-173 Оценка изменения скорости кровотока в коже Измерение скорости в коже на латеральной поверхности задней правой конечности крыс осуществляли неинвазивно допплерографическим методом с применением системы ультразвукового допплерографа датчика УЗОП-010-01 с рабочей частотой 25МГц и программного комплекса ММ-Д-К-Minimax Doppler v.2.1 («Минимакс» Санкт-Петербург, Россия).…”

Section: экспериментальная модель хронической венозной недостаточностиunclassified

Comparative study of the effectiveness of phlebotonic drugs in the experiment

Поздняков

Kozlova

Карманович

et al. 2023

Ambulatornaya khirurgiya

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Introduction. Chronic venous diseases are a common group of diseases with a significant risk of complications requiring timely correction. As a rule, phlebotonic drugs based on flavonoid complexes are used for the treatment and prevention of venous diseases.Aim. To evaluate the effectiveness of the use of various phlebotonic drugs in the conditions of experimental chronic venous insufficiency.Materials and methods. Varicose veins were modeled in Wistar rats by partial stricture of the deep femoral vein. The studied medicines were administered orally in a course of 30 days from the moment of surgery. During the work, the change in the following parameters was evaluated: the rate oflocal blood flow in the skin in dynamics, the degree of vascular permeability, the concentration of proinflammatory cytokines (TNF-α, IL-6) and matrix metalloproteinase 9 (MMP9) in the vascular wall. The rate of local blood flow was assessed by ultrasound Dopplerography. The change of vascular permeability was studied by the degree of extravasation of the Evans blue dye in the Miles test. The content of proinflammatory cytokines and MMR9 was determined by enzyme-linked immunoassay. The results were statistically processed.Results. The study showed that the course oral administration of all the studied venotonizing drugs led to the restoration of hemodynamics and a significant (p˂ 0.05) decrease in the degree of vascular permeability in relation to untreated animals. It is worth noting that the use of a micronised purified flavonoid fraction 1 contributed to the development of a more pronounced vasal effect, which was reflected in an increase in blood flow velocity and a decrease in vascular permeability compared to the rest of the studied drugs. At the same time, the administration of micronised purified flavonoid fraction 1 to animals led to a statistically significant decrease in the concentration of proinflammatory cytokines, which was not observed when using other drugs.Conclusion. The course administration of the micronised purified flavonoid fraction 1leads to the development of a pronounced phlebotonic effect, expressed in the restoration of microcirculation, a decrease of the inflammation in the vascular wall.

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Section: экспериментальная модель хронической венозной недостаточностиunclassified

Comparative study of the effectiveness of phlebotonic drugs in the experiment

Поздняков

Kozlova

Карманович

et al. 2023

Ambulatornaya khirurgiya

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Section: экспериментальная модель хронической венозной недостаточностиunclassified

Comparative evaluation of the effectiveness of phlebotonic gels

Поздняков

Шабанова

Gerashchenko

et al. 2022

Ambulatornaya khirurgiya

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Introduction. Varicose veins are a common disease with a chronic course and a high risk of complications and cosmetic defects. Venotonic drugs are widely used in conservative treatment of varicose veins.Aim. To study the comparative efficacy of venotonic drugs for local application in experimental conditions.Materials and Methods. Varicose veins were modeled in Wistar rats by partial stricture of the deep femoral vein. The studied drugs were applied in the course of 14 days from the operation. The assessed parameters were the change of local blood flow velocity in the skin in the dynamics and the degree of vascular permeability. The rate of local blood flow was assessed by Doppler ultrasound. Changes in vascular permeability were studied by the degree of extravasation of Evans blue dye in the Miles test. The results were processed using the methods of variation statistics.Results. The study showed that under the conditions of experimental chronic venous insufficiency, a course of application of all the analyzed drugs resulted in an increase in the rate of local blood flow in the skin and a decrease in the degree of vascular permeability. It was noted that application of the investigated gel based on escin, heparin and essential phospholipids to the skin of animals resulted in reliably (p < 0,05) lower indices of vascular permeability in comparison with the rats which received a course therapy with the heparin-containing gel; combined cosmetic agent as well as the gel based on troxerutin, heparin and dexpanthenol.Discussion. The results obtained testify that application of external dosage forms of combined venotonic drugs promotes the regression of chronic venous insufficiency manifestations. Maximum evident effect was registered while applying the studied drug, that can be related to its complex composition including essential phospholipids, heparin and aescin. It is known that aescin is a phlebotonic with a high degree of percutaneous absorption, the effect of which is significantly potentiated by the phospholipid component.Conclusions. The application of the combined product based on heparin, aescin and essential phospholipids provided an optimum rate of onset of pharmacological effect compared to the other analysed compositions.

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Therapeutic Potential of Molsidomine-Loaded Liquid Crystal Nanoparticles for the Treatment and Management of Niacin-Induced Varicose Veins: In Vitro and In Vivo Studies

Javaid,

Sharma,

et al. 2024

ACS Appl. Bio Mater.

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Initiation of reticular and spider veins, incompetent perforantes and varicose veins in the saphenous vein network of the rat

Cited by 4 publications

References 14 publications

Comparative study of the effectiveness of phlebotonic drugs in the experiment

Comparative study of the effectiveness of phlebotonic drugs in the experiment

Comparative evaluation of the effectiveness of phlebotonic gels

Therapeutic Potential of Molsidomine-Loaded Liquid Crystal Nanoparticles for the Treatment and Management of Niacin-Induced Varicose Veins: In Vitro and In Vivo Studies

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