Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients

Abstract

Background:Type 2 diabetes mellitus (T2DM) has traditionally been considered to affect mainly the elderly; however, the age at diagnosis has gradually reduced in recent years. Although the incidence of young-onset T2DM is increasing, it is still not fully clear the onset characteristics and risk factors of early-onset T2DM. The aim of this study was to describe the initiating characteristics of early-onset T2DM in Chinese patients and evaluate the risk factors for diabetes mellitus.Methods:This cross-sectional controlled study was performed using a questionnaire survey method in outpatients of multiple centers in China. A total of 1545 patients with T2DM with an age at onset of <40 years were included, and the control group consisted of subjects aged <40 years with normal blood glucose level.Results:In patients with young-onset T2DM, the mean age and initial hemoglobin 1Ac at diagnosis were 32.96 ± 5.40 years and 9.59 ± 2.71%, respectively. Most of the patients were obese, followed irregular diet pattern and sedentary lifestyle, had life or work pressure, and had a family history of diabetes mellitus. Compared with subjects with normal blood glucose level, logistic regression analysis showed that waist-to-hip ratio (odds ratio [OR] 446.99, 95% confidence interval [CI] 42.37–4714.87), family history of diabetes mellitus (OR 23.46, CI 14.47–38.03), dyslipidemia (OR 2.65, CI 1.54–4.56), diastolic blood pressure (OR 1.02, CI 1.00–1.04), and body mass index (OR 0.95, CI 0.92–0.99) are independent factors for early-onset T2DM.Conclusions:We observed that abdominal obesity, family history of diabetes mellitus, and medical history of hypertension and dyslipidemia are independent risk factors for early-onset T2DM. It is, therefore, necessary to apply early lifestyle intervention in young people with risk of diabetes mellitus.

Sleep problems of healthcare workers in tertiary hospital and influencing factors identified through a multilevel analysis: a cross-sectional study in China

“…Although healthcare workers in China’s top-three hospitals treat numerous patients, few workers are mindful of their own health issues. Studies have shown that continuous exposure to factors such as lack of sleep, exercise and a regular diet, as was found here, may increase the risk of chronic diseases among healthcare workers 10 62 63. The fact that healthcare workers do not pay proper attention to their own health should be recognised by the government and society.…”

The Constellation of Macrovascular Risk Factors in Early Onset T2DM: A Cross-Sectional Study in Xinjiang Province, China

“…These data suggest that adults with early onset T2DM represent a substantial proportion of patients consuming medical resource even in economically underdeveloped areas of China. Of note, patients with early onset T2DM, despite of younger ages and shorter durations of diabetes, had poorer plasma glucose control than those patients with late onset [ 8 , 15 , 16 ]. Thus, prevention of diabetes, especially among individuals aged below 40 years, should be regarded as a public health emergency in such area.…”

Elevated Levels of Very Low-density Lipoprotein Cholesterol Independently Associated with In-stent Restenosis in Diabetic Patients after Drug-eluting Stent Implantation

“…[ 24 ] Moreover, they often had dyslipidemia and systemic prothrombotic state related to the activation of the platelet aggregation and coagulation systems. [ 6 25 ] Altogether, these made diabetic patients a challenging subpopulation who should be given more specific treatment and management. Thus, it was very significant to find reliable factors to predict the risk of ISR, especially in diabetic patients.…”

“…A recent multicenter study showed that the prevalence of dyslipidemia had reached up to 67.1% in diabetic patients in China,[ 6 ] which was uniquely manifested by the high level of VLDL-C and TG, low level of HDL-C, but the usually normal level of LDL-C.[ 7 ] Increasing evidence indicated that triglycerides-rich lipoprotein (TGRL) was one of the most important residual risk factors of CVD beyond LDL-C.[ 10 26 27 ] The fasting serum TG was usually measured as the most common biomarker of TGRL. However, many prospective epidemiological studies suggested that serum TG might not capture the true extent of CVD risk, and failed to fully reflect the cholesterol content of VLDL.…”

“…[ 3 ] Especially among patients with diabetes mellitus (DM), the risk of developing ISR after PCI appeared to be 2–4 times higher compared with nondiabetic patients. [ 4 5 ] What's more, about 67% of diabetic patients had dyslipidemia and young-onset type 2 DM (T2DM) is increasing in China,[ 6 ] which was uniquely manifested by the high levels of very low-density lipoprotein cholesterol (VLDL-C) and triglyceride (TG), but the usually normal level of low-density lipoprotein cholesterol (LDL-C). [ 7 ] Of which, accumulating evidence suggested that VLDL-C was a significant risk factor for atherosclerosis and cardiovascular disease (CVD).…”