Initial medication non‐adherence: prevalence and predictive factors in a cohort of 1.6 million primary care patients

Abstract

The rate of IMNA is high when all medications are taken into account. Attempts to strengthen trust in resident general practitioners and improve motivation to initiate a needed medication in the general young and older immigrant population should be addressed in Catalan PC.

Effect of copayment policies on initial medication non-adherence according to income: a population-based study

“…In line with our results, the study showed an increase in non-adherence to costly drugs and this was especially pronounced in the pensioner population 12. IMNA occurs when a first prescription of a new treatment is not dispensed, and rational use of medicines is not relevant, although it could partially explain IMNA in analgesics 16. The only two studies that assessed a similar situation21 22 observed that fixed copayment followed by an income-based copayment caused an increase in IMNA in antidepressant and inhaled medications compared with the period when this medication was free of charge and that the impact of the fixed copayment was greater than that of the coinsurance measure.…”

“…IMNA prevalence ranged from 9.7% to 24.9% in the initial period, with population groups containing higher proportions of older people16 showing lower IMNA levels.…”

“…To identify newly prescribed medicines, we considered a 3-month preperiod (time with no prescriptions for drugs from the same pharmacotherapeutic group) (1 month for penicillins) 16. Information was collected on prescriptions and used to estimate IMNA.…”

“…We gathered sociodemographic and clinical data from patients, including sex, age, place of origin (Spain, Europe, Africa, Americas and Asia-Oceania), socioeconomic status (five categories, from low to high for urban areas, and a rural category) and comorbidities (recorded in the International Classification of Diseases, 10th Revision, and grouped into most prevalent pathologies16). Month and week of prescription were also used as covariates.…”

Once Again About the Hierarchy of Evidences in Medicine or Whether It Is Possible to Choose the Most Effective and Safe Drug With the Help of Observational Studies

“…Согласно сообщению ABDA (Федеральный союз аптечных ассоциаций Гер-мании), каждый второй пациент при долгосрочной терапии принимает лекарственные препараты не в со-ответствии с врачебными рекомендациями [26,27]. По данным испанских ученых (проанализированы дан-ные 1,6 млн пациентов, которым было выписано 2,9 млн рецептов), начальная неприверженность медикамен-тозному лечению (больной не получил препарат по вы-писанному рецепту) в среднем составила 17,6% (наи-высшая -для анилидов (парацетамол) -22,6%, наи-меньшая -для ингибиторов АПФ -7,4% [28]. Согласно результатам другого подобного исследования (75,5 тысяч пациентов, около 200000 рецептов) первично были реализованы только 78% рецептов (для новых ле-карственных препаратов -только 72%).…”