‘Drugs don't work in patients who don't take them’ (C. Everett Koop, MD, US Surgeon General, 1985)

Lindenfeld, JoAnn; Jessup, Mariell

doi:10.1002/ejhf.920

Cited by 34 publications

(16 citation statements)

References 9 publications

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“…Data from other studies in different countries of LA show adherence rates ranging between 50 and 70%. The data obtained from this survey shows a significant worsening of adherence, at least from the 1 st months of the pandemic [18][19][20][21][22] .…”

Section: Discussionmentioning

confidence: 80%

Impacto de la pandemia COVID-19 en pacientes cardiometabólicos sin infección por SARS-CoV-2 en Latinoamérica

Camilletti¹,

Renna²,

Santi³

et al. 2024

ACM

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A cross-sectional survey including 38 questions about demography, clinical condition, changes in health habits, and medical treatments for cardiometabolic patients in outpatient follow-up was conducted. From June 15 to July 15, 2020, a total of 13 Latin-American countries participated in enrolling patients. These countries were divided into 3 geographic regions: Region 1 including North, Central, and Caribbean Regions (NCCR), Region 2 including the Andean Region (AR), and Region 3 including the Southern Cone Region (SCR). 4.216 patients were analyzed, resulting in a coefficient of 33.82%, 32.23%, and 33.94% for NCCR, AR, and SCR, respectively. Significant differences were found between the AR, SCR, and NCCR regions. The analysis of habitual medication usage showed that discontinued use of medication was more present in AR, reaching almost 30% (p < 0.001). The main finding of this study was the negative impact that restrictive measures have on adherence to medications and physical activity: Rs = 0.84 (p = 0.0003) and Rs = 0.61 (p = 0.0032), respectively. AR was the most vulnerable region. Restrictive quarantine measures imposed by the different countries showed a positive correlation with medication discontinuation and a negative correlation with physical activity levels in patients analyzed. These findings characterize the impact of the consequences left by this pandemic. Undoubtedly, restrictive measures have been and will continue to have reverberating negative effects in most Latin-American countries.

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Section: Discussionmentioning

confidence: 80%

Impacto de la pandemia COVID-19 en pacientes cardiometabólicos sin infección por SARS-CoV-2 en Latinoamérica

Camilletti¹,

Renna²,

Santi³

et al. 2024

ACM

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“…He understood there must be trust and honesty between both parties, and a doctor’s help can only go as far as patients are willing to cooperate. Every patient has the power to render any oral medication 100% ineffective, no matter how much money, time, or human resources the pharmaceutical industry infuses into its creation; a drug is only effective if it is taken [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Use of an Ingestible, Sensor-Based Digital Adherence System to Strengthen the Therapeutic Relationship in Serious Mental Illness

Richey¹,

Kovacs²,

Browne³

2022

JMIR Ment Health

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Serious mental illness is a chronic condition that requires long-term pharmacological treatment. Adherence to oral antipsychotic medication has specific nuances that affects patients and physicians alike. For patients with serious mental illness, nonadherence increases their risk of hospitalization and relapse. Nonadherence is a formidable barrier for physicians in accurately assessing medication efficacy and helping patients achieve their fullest potential. A digital adherence system approved by the Food and Drug Administration can provide near–real time aripiprazole ingestion information. The system records ingestions through an embedded ingestible sensor in oral aripiprazole, which sends a transient local signal to a patch worn on the patient’s torso that is then stored on a paired smartphone app. With patient permission, these data can be viewed remotely by their physician, along with a patient’s mood, activity, and time spent resting. Such data are able to do the following: reveal broad patterns of medication adherence behavior to the patient as well as their physician; help physicians and patients understand and create more realistic expectations for adherence; promote discussion of treatment options; and minimize therapeutic appointment time devoted to determining actual adherence, thereby maximizing the time available to address each patient’s distinctive reasons for their adherence pattern. Crucially, extra time created during appointments can be used to strengthen the therapeutic relationship, which may translate into both improvements in adherence and patient attitude toward their medication. Future investigations are needed to examine how this technology impacts the development of training and best practice guidelines for its use. Otherwise, the potential benefits of this technology may be lost, or worse, inadequate and inappropriate use may harm the therapeutic relationship.

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“…A number of studies have shown that SPC regimens are associated with improved adherence [ [6] , [7] , [8] ]. Moreover, adherence is a key factor in successful hypertension management and high adherence could reduce complications and hospitalizations [ [9] , [10] , [11] ]. SPC has also been shown to reduce clinical inertia, one of the main challenges contributing to the low global efficiency of antihypertensive treatment [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Projecting the long-term benefits of single pill combination therapy for patients with hypertension in five countries

Borghi

Wang

Родионов

et al. 2021

International Journal of Cardiology Cardiovascular Risk and Pre

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‘Drugs don't work in patients who don't take them’ (C. Everett Koop, MD, US Surgeon General, 1985)

Cited by 34 publications

References 9 publications

Impacto de la pandemia COVID-19 en pacientes cardiometabólicos sin infección por SARS-CoV-2 en Latinoamérica

Impacto de la pandemia COVID-19 en pacientes cardiometabólicos sin infección por SARS-CoV-2 en Latinoamérica

Use of an Ingestible, Sensor-Based Digital Adherence System to Strengthen the Therapeutic Relationship in Serious Mental Illness

Projecting the long-term benefits of single pill combination therapy for patients with hypertension in five countries

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