Initial management of candidemia at an academic medical center: Evaluation of the IDSA guidelines

Observational study of the epidemiology and outcomes of vancomycin-resistantEnterococcusbacteraemia treated with newer antimicrobial agents

“…Second, there were important differences in patients who received daptomycin or linezolid therapy, including neutropenia and number of ID consultations. Differences in ID consultation may be relevant, as published reports demonstrate decreased mortality in patients with candidemia and staphylococcal bacteremia in patients who received ID consultation [32, 33]. Lastly, our finding that transplant patients had a lower mortality is likely spurious and suggests confounding in this investigation.…”

The impact of infectious diseases consultation on oncology practice

“…Since 2005-2006, the proportion of hospitalized patients at our tertiary cancer center for whom infectious diseases consultation services were sought increased from 7.0 to 13.8% in 2011-2012 (Victor Mulanovich, personal communication, 15 January 2013). Existing literature, composed mostly of noncancer patients, showed the importance of infectious diseases consultation in reducing mortality associated with bloodstream infection, from S. aureus bacteremia [19] to candidemia [24,25]. The role of infectious diseases consultation in managing the transition from inpatient to outpatient settings was pointed out, including discontinuation of antibiotics, change to an oral agent, or change in selection of antibiotic [27,29].…”

“…A study conducted in Alabama showed a 33% increase in mortality associated with variation from guidelines (57 vs. 24%, P ¼ 0.003) [24]. In addition, infectious diseases consultation resulted in a 21% reduction in 6-week mortality (18 vs. 39%, P < 0.01) [24]. A study conducted in Japan demonstrated a 34% increase in 30-day survival (78 vs. 44%, P ¼ 0.04), 31% increase in appropriate antifungal use (81 vs. 50%, P ¼ 0.046), and 33% increase in appropriate duration of therapy (95 vs. 62%, P < 0.01) [25].…”

“…A study conducted in Alabama showed a 33% increase in mortality associated with variation from guidelines (57 vs. 24%, P ¼ 0.003) [24]. In addition, infectious diseases consultation resulted in a 21% reduction in 6-week mortality (18 vs. 39%, P < 0.01) [24].…”

The Hidden Threats ofCandida spp.to the Respiratory Tract

“…1 However, for specimens from colonized sites, the criteria continues to be controversial and still needs to be well established. We would like to share our past experience with an intensive care unit (ICU) patient who likely developed pneumonia due to Candida tropicalis (C. tropicalis), but the findings were ignored because of the difficulty in distinguishing infection from normal colonization.…”