Initial Experience of Surgical Microwave Tissue Precoagulation in Liver Resection for Hepatocellular Carcinoma in Cirrhotic Liver

Abdelraouf, Amr; Hamdy, Hussam; Erian, El; Elsebae, Magdy M.A.; S, Taha; He, Elshafey; Ismail, Sahar A.; Hassany, Mohamed

doi:10.12816/0006472

Cited by 6 publications

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“…A great deal of experimental researches showed that the tumor cell with the volume, less than 2 mm 3 mainly depends on diffusion for supply of energy and oxygen, waste excretion as well as to maintain its own survival till the growth of any blood vessel in tumor (20)(21)(22). At this stage, the apoptosis and the hyperplasia of tumor cells are in the balance.…”

Section: Discussionmentioning

confidence: 99%

β-elemene enhances anticancer and anti-metastatic effects of osteosarcoma of ligustrazine inï¿½vitro and inï¿½vivo

et al. 2018

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Abstract. The present study aimed to determine the anticancer effects of the combination of β-elemene and ligustrazine in vitro as well as in in vivo. Following evaluation using an MTT assay, β-elemene, ligustrazine and the β-elemene-ligustrazine combination treatments all exhibited the capacity to inhibit the growth of OS-732 cells, with inhibitory rates of 43.3, 54.4, and 75.0%, respectively. Using a flow cytometry assay, it was determined that the β-elemene-ligustrazine combination possessed the highest apoptotic rate (30.6%). Furthermore, β-elemene-ligustrazine combination treatment resulted in the highest downregulation of G protein-coupled receptor 124, vascular endothelial growth factor, matrix metallopeptidase (MMP)-2 and MMP-9 mRNA, and protein expression levels. In addition, the combined treatment led to an increase in the mRNA and protein expression of endostatin, TIMP metallopeptidase inhibitor (TIMP)-1 and TIMP-2 in OS-732 cells. Additionally, β-elemene-ligustrazine caused a decrease in nuclear factor-κB, interleukin-8, C-X-C motif chemokine receptor 4 and urokinase-type plasminogen activator mRNA expression, as well as an increase in caspase-3, caspase-8, and caspase-9 mRNA expression. In vivo, the β-elemene-ligustrazine combination was able to reduce the weight and the bulk of the tumor in BALB/c-nu/nu nude mice compared with any other group. All the results described above regarding changes to mRNA and protein expression were further confirmed in vivo in the tumor tissue of mice. The results of the present study have suggested that the combination of β-elemene-ligustrazine exhibits greater anticancer effects compared with β-elemeneor ligustrazine-alone treatment.

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Section: Discussionmentioning

confidence: 99%

β-elemene enhances anticancer and anti-metastatic effects of osteosarcoma of ligustrazine inï¿½vitro and inï¿½vivo

et al. 2018

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“…Microwave technology has been used recently to reduce bleeding from the liver parenchyma by coagulating the tissue before liver transection [7][8][9]. Francone et al [17] found that thermoablative precoagulation of the transection line for laparoscopic ultrasound-guided liver resection can achieve minimal blood loss and reduce the need for perioperative transfusions during parenchymal transection.…”

Section: Discussionmentioning

confidence: 99%

“…In a previous study, we reported successful control of emergent intraoperative hepatic tumor bleeding by MWA [6]. Recently, microwave technology has been used for cutting by coagulating the liver parenchyma prior to transection [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Precoagulation with microwave ablation for hepatic parenchymal transection during liver partial resection

Rao

Ling

Dai

et al. 2018

International Journal of Hyperthermia

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Purpose: To evaluate the feasibility of precoagulation with microwave ablation (MWA) for hepatic parenchymal transection during liver partial resection. Methods: A total of 66 eligible patients were enrolled in this double-blind, randomized, controlled study. Patients were randomized to receive either the traditional clamp-crushing method (Control group) or the MWA precoagulation method (MWA group) for hepatic parenchymal transection during liver partial resection. The operative time, hepatic portal occlusion time, intraoperative blood loss and transfusion, postoperative complications and recovery outcomes were compared. Results: Compared to the Control group, the MWA group had significantly less intraoperative blood loss. Fewer red blood cell transfusions were observed in the MWA group but without statistical significance. The MWA group showed significantly higher serum alanine aminotransferase and aspartate aminotransferase levels at day 1 postoperatively, but no differences between the MWA and Control groups were found at days 3 and 7. There were no significant differences in terms of operative time, hepatic portal occlusion time, postoperative total bilirubin levels, human albumin solution consumption or length of hospital stay. Postoperative complications such as impaired renal function, pyrexia, admission to ICU, abscess, biliary leakage, intrahepatic and distant tumor recurrence and in-hospital mortality were comparable between the two groups. Conclusion: Precoagulation with MWA reduced intraoperative blood loss with similar postoperative complications, providing a safe, effective, novel alternative for hepatic parenchymal transection during liver partial resection. Additional results from larger series are recommended to confirm these findings.

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“…Microwave energy has also been used as precoagulation method in liver surgery [23][24][25] and similarly causes coagulative necrosis of the liver parenchyma, but can potentially achieve a larger coagulation volume in a shorter time in comparison with radiofrequency ablation, although results seem comparable [26,27].…”

Section: Back In 2002 Weber Et Al Introduced a New Technique For Liver Resectionmentioning

confidence: 99%

The journey of radiofrequency-assisted liver resection

et al. 2018

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Initial Experience of Surgical Microwave Tissue Precoagulation in Liver Resection for Hepatocellular Carcinoma in Cirrhotic Liver

Cited by 6 publications

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β-elemene enhances anticancer and anti-metastatic effects of osteosarcoma of ligustrazine inï¿½vitro and inï¿½vivo

β-elemene enhances anticancer and anti-metastatic effects of osteosarcoma of ligustrazine inï¿½vitro and inï¿½vivo

Precoagulation with microwave ablation for hepatic parenchymal transection during liver partial resection

The journey of radiofrequency-assisted liver resection

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