Initial butyrate producers during infant gut microbiota development are endospore formers

Appert, Olivia; Garcia, Alejandro Ramirez; Frei, Remo; Roduit, Caroline; Constancias, Florentin; Bunešová, Věra; Ferstl, Ruth; Zhang, Jianbo; Akdiş, Cezmi A.; Lauener, Roger; Lacroix, Christophe; Schwab, Clarissa

doi:10.1111/1462-2920.15167

Cited by 65 publications

(100 citation statements)

References 54 publications

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“…have important roles in improving both glucose homeostasis and weight loss [ 23 ]. Meanwhile, Phascolarctobacterium is a producer of short-chain fatty acids (SCFAs), including butyrate, acetate, and propionate, which positively correlate with weight loss, and Faecalibacterium prausnitzii also produces butyrate [ 24 , 25 ]. It is also known that Succinivibrio helps regulate the energy balance [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Both Gut Microbiota and Differentially Expressed Proteins Are Relevant to the Development of Obesity

Peng

et al. 2020

BioMed Research International

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Although the role of the gut microbiota in obesity has recently received considerable attention, the exact mechanism is unclear. This study was aimed at investigating the profiles of bacterial communities in fecal samples and differentially expressed proteins (DEPs) in the peripheral blood in mice fed a high-fat diet (HFD) and standard diet (SD) and at providing new insights into the pathogenesis of obesity. The profiles of bacterial communities in fecal samples and DEPs in the peripheral blood were characterized in mice fed HFD and SD, respectively. The levels of 3 DEPs increased in HFD mice. The alpha diversity was significantly lower after 4 and 12 weeks in HFD mice. The beta diversity was higher after 4, 8, and 12 weeks in HFD mice. A total of 16 gut bacterial clades were significantly different with the linear discriminant analysis (LDA) score higher than 4 over time. The relative abundance levels of Proteobacteria and Deferribacteres were higher, while those of Bacteroidetes and Firmicutes were lower in HFD mice at the phylum level. The relative abundance of Desulfovibrionaceae and Rikenellaceae increased in HFD mice at the family level. The relative abundance of the Bacteroidetes_S24-7_group and Lachnospiraceae was lower in HFD mice. The gut microbiota had a significant correlation with serum lipid indexes and expression of DEPs at the phylum and family levels. The changes in the gut microbiota of HFD mice and their associations with the levels of inflammatory proteins could be one of the major etiological mechanisms underlying obesity.

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Section: Discussionmentioning

confidence: 99%

Both Gut Microbiota and Differentially Expressed Proteins Are Relevant to the Development of Obesity

Peng

et al. 2020

BioMed Research International

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“…At 90 days, endospore-forming Clostridium senso stricto was the highest of the butyrate-producing bacteria present in the infant gut microbiome. 97 Low levels of butyrate, a short-chain fatty acid and product of glycolysis have been linked to allergic diseases later in life. 98,99…”

Section: Development Of the Sporobiota Over Timementioning

confidence: 99%

The Sporobiota of the Human Gut

et al. 2021

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“…observed in human faecal metagenomes, which together contribute about 85% of all gdh in human faecal metagenomes (Zhang et al, 2019a) (Supplementary Table 2). Reactions were performed as described by Appert et al (2020). Full method is provided in the supplementary information.…”

Section: Preparation Of a Hallii Dsm 3353 Culturesmentioning

confidence: 99%

Impact of manipulation of glycerol/diol dehydratase activity on intestinal microbiota ecology and metabolism

Garcia

Zhang

Greppi

et al. 2021

Environmental Microbiology

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Glycerol/diol dehydratases (GDH) are enzymes that catalyse the production of propionate from 1,2-propanediol, and acrolein from glycerol. Acrolein reacts with dietary carcinogenic heterocyclic amines (HCA), reducing HCA mutagenicity, but is itself also an antimicrobial agent and toxicant. Gut microbial GDH activity has been suggested as an endogenous acrolein source; however, there is limited information on the potential of the intestinal microbiota to have GDH activity, and what impact it can have on the intestinal ecosystem and host health. We hypothesized that GDH activity of gut microbiota is determined by the abundance and distribution of GDH-active taxa and can be enhanced by supplementation of the GDH active Anaerobutyricum hallii, and tested this hypothesis combining quantitative profiling of gdh, model batch fermentations, microbiota manipulation, and kinetic modelling of acrolein formation. Our results suggest that GDH activity is a common trait of intestinal microbiota shared by a few taxa, which was dependent on overall gdh abundance. Anaerobutyricum hallii was identified as a key taxon in GDH metabolism, and its supplementation increased the rate of GDH activity and acrolein release, which enhanced the transformation of HCA and reduced fermentation activity. The findings of this first systematic study on acrolein release by intestinal microbiota indicate that dietary and microbial modulation might impact GDH activity, which may influence host health.

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Initial butyrate producers during infant gut microbiota development are endospore formers

Cited by 65 publications

References 54 publications

Both Gut Microbiota and Differentially Expressed Proteins Are Relevant to the Development of Obesity

Both Gut Microbiota and Differentially Expressed Proteins Are Relevant to the Development of Obesity

The Sporobiota of the Human Gut

Impact of manipulation of glycerol/diol dehydratase activity on intestinal microbiota ecology and metabolism

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