2011
DOI: 10.1590/s0103-507x2011000200007
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Inibição da atividade da citrato sintase cerebral em um modelo animal de sepse

Abstract: Objective: An extensive body of evidence from experimental studies indicates that sepsis is associated with increased reactive oxygen species production, depletion of antioxidants, and accumulation of markers of oxidative stress. Moreover, mitochondrial dysfunction has been implicated in the pathogenesis of multiple organ dysfunction syndrome (MODS). Citrate synthase is an enzyme localized in the mitochondrial matrix and an important component of the Krebs cycle; consequently, citrate synthase has been used as… Show more

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Cited by 9 publications
(1 citation statement)
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“…To determine the function of mitochondria in the Krebs cycle, we examined the activity of citrate synthase (CS). CS is an enzyme localized in the mitochondrial matrix and is used as a quantitative enzymatic marker for the presence of intact mitochondria [ 65 , 66 ]. Our data indicate that long-term DEXA administration decreased CS activity in the hippocampus, while vitamin D 3 supplementation contributed to maintaining proper enzyme activity.…”
Section: Discussionmentioning
confidence: 99%
“…To determine the function of mitochondria in the Krebs cycle, we examined the activity of citrate synthase (CS). CS is an enzyme localized in the mitochondrial matrix and is used as a quantitative enzymatic marker for the presence of intact mitochondria [ 65 , 66 ]. Our data indicate that long-term DEXA administration decreased CS activity in the hippocampus, while vitamin D 3 supplementation contributed to maintaining proper enzyme activity.…”
Section: Discussionmentioning
confidence: 99%