2019
DOI: 10.1007/s10571-019-00750-z
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Atorvastatin Relieves Cognitive Disorder After Sepsis Through Reverting Inflammatory Cytokines, Oxidative Stress, and Neuronal Apoptosis in Hippocampus

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Cited by 17 publications
(10 citation statements)
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“…Similar to our ndings, endotoxin LPS, an in ammatory stimulator, has been reported to induce cognitive de cits in mice through neuroin ammation and neuronal apoptosis [16]. Inhibition of in ammatory cytokines, oxidative stress, and neuronal apoptosis in the hippocampus also ameliorated cognitive de cits in mouse model of AD [50], vascular dementia and Sepsis [51].…”
Section: Discussionsupporting
confidence: 88%
“…Similar to our ndings, endotoxin LPS, an in ammatory stimulator, has been reported to induce cognitive de cits in mice through neuroin ammation and neuronal apoptosis [16]. Inhibition of in ammatory cytokines, oxidative stress, and neuronal apoptosis in the hippocampus also ameliorated cognitive de cits in mouse model of AD [50], vascular dementia and Sepsis [51].…”
Section: Discussionsupporting
confidence: 88%
“…Although we assessed inflammatory mediators, we did not detect oxidative stress biomarkers, which were also reported to be involved in SAE-induced learning and memory impairment. 88 , 89 2. In this study, we assessed the learning and memory ability, VP level, cytokine levels, and BDNF levels at a single time point (ie, after 30 days of housing).…”
Section: Discussionmentioning
confidence: 99%
“…Robust evidence indicates that atorvastatin may be helpful in treating various cardiovascular diseases, such as coronary heart disease, atherosclerosis, and hypertension. Tian and coworkers [ 3 ] found that atorvastatin improved cognitive disorders in a sepsis mouse model by mediating inflammatory cytokines, oxidative stress, and neuronal apoptosis in the hippocampus. Thassakorn et al [ 16 ] reported that atorvastatin exerts antioxidant and anti-inflammatory effects in dogs with heart failure.…”
Section: Discussionmentioning
confidence: 99%
“…Statins, which inhibit 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA) activity, are widely used in the treatment of dyslipidemia and to decrease the severity of other cardiovascular events in patients with coronary heart disease. More recently, pleiotropic protective effects of statins, including antioxidant, pro-apoptosis, and anti-inflammatory effects in vascular tissue, have been described [ 1 3 ]. These findings indicate that statins may have additional therapeutic uses.…”
Section: Introductionmentioning
confidence: 99%