Inhibitory role of regucalcin in the regulation of nitric oxide synthase activity in rat brain cytosol: involvement of aging

Genomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease

“…24 In our study, nitric oxide synthase expression may also have been increased by downregulation of senescence marker protein-30 (2.5-fold decrease), which normally exerts an inhibitory effect on this enzyme. 25 The importance of nitric oxide and endothelin-1 in dogs with DMVD has been previously demonstrated by increased NADPH-diaphorase activity 5 (a surrogate marker for nitric oxide synthase activity), endothelin-1 receptor density, 4 and insulinlike growth factor 26 (a stimulus for endothelial nitric oxide production).…”

Regucalcin is widely distributed in the male reproductive tract and exerts a suppressive effect on in vitro sperm capacitation in the water buffalo (Bubalus bubalis)

“…Regucalcin participates in Ca 2+ homeostasis by regulating ion transport across the cell membrane and between the cytoplasm and the nucleus, microsomes, endoplasmic reticulum, and mitochondria (Yamaguchi, ). Regucalcin also reportedly interacts with several intracellular signaling pathways through its regulation of Ca 2+ ‐dependent enzymes such as tyrosine kinases, phosphatases, phosphodiesterase, and nitric oxide synthase (Katsumata and Yamaguchi, ; Baba and Yamaguchi, ; Tobisawa and Yamaguchi, ; Fukaya and Yamaguchi, ; Yamaguchi, , ).…”

Calcium Regulatory Protein, Regucalcin, may be a Key Molecule in Brain Disease

“…Moreover, regucalcin has been found to inhibit nitric oxide (NO) synthase activity in the cytosol of rat brain tissues [32]. NO synthase is activated by Ca 2+ /calmodulin which relates to Ca 2+ signaling.…”