Genomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease

Oyama, Mark A.; Chittur, Sridar V.

doi:10.2460/ajvr.67.8.1307

Cited by 78 publications

(122 citation statements)

References 44 publications

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“…It has been suggested that MMVD is functionally and pathologically similar in humans and dogs [13]. In a previous study, increased circulating 5-HT concentration as a potential source of heightened 5-HT signaling was demonstrated in small dogs with MMVD [11]. 5-HT concentration was decreasing with the increase of MMVD severity [13].…”

Section: Introductionmentioning

confidence: 99%

“…In relation to appetite, 5-HT interacts with leptin, the first identified adipokine. In the cardiovascular system, it has been recently reported that 5-HT has a role in the development of mitral valve disease [11]. 5-HT-related mechanism which is increased 5-HT signaling or decreased 5-HT clearance may lead to valvulopathy in humans and animal models.…”

Section: Introductionmentioning

confidence: 99%

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Serum serotonin concentration in lean and obese dogs with myxomatous mitral valve disease

Kim

Park

Hyun

et al. 2016

Korean Journal of Veterinary Research

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Abstract:The aim of the present study is to investigate the potential influence of obesity as a factor in 5-hydroxytryptamine (5-HT) concentration in myxomatous mitral valve disease (MMVD) dogs. Fifty-five client-owned dogs were enrolled in a randomized trial. Dogs were classified by echocardiography into healthy (control), mild, and moderate to severe MMVD groups. Each group was subclassified by using a 9-point body condition score (BCS); lean (BCS 5-6/9) and obese groups (BCS 7.5-9/9). Dogs with moderate to severe MMVD had lower serotonin (5-HT) concentrations than the control group (p = 0.03). Dogs with moderate to severe MMVD (p = 0.017) had lower serum 5-HT concentrations than the control group in the obese group (BCS 7.5-9/9). Significant difference was found between the lean and obese groups (p = 0.015) which are not consider severe in the MMVD group. These results suggested that 5-HT concentration was decreased with the increasing severity of MMVD, and obesity might be taken into consideration when interpreting the serotonin concentration in MMVD dogs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum serotonin concentration in lean and obese dogs with myxomatous mitral valve disease

Kim

Park

Hyun

et al. 2016

Korean Journal of Veterinary Research

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“…Such studies do not reveal which are the genes responsible for the particular disease, but do allow the assessment of gene expression, as they enable the analysis of the whole genome. Gene expression may play a role in the development and progression of heart diseases and the studies can be used to further our knowledge of canine MVD by showing differences between healthy and diseased dogs, as well as between the different stages of MVD (6,18). They might provide not only information about the disease process, but also possible new biomarkers to be used in cardiovascular diagnostics and therapy assessment.…”

Section: Introductionmentioning

confidence: 99%

“…Studies on affected tissues have shown up-regulation of MMP-1 and MMP-9 as well as collagen III (25), serotonin receptor 2B (18), MMP-1, MMP-14, and tissue inhibitors of metalloproteinases (TIMPs) such as TIMP-2, TIMP-3, and TIMP-4 (2, 3). Studies of tissue from affected hearts have also shown down-regulation of gene expression in the course of mitral valve disease, namely down-regulation of the microfibrillar, glycoprotein, and noncollagen extracellular matrix genes, TGF-ßR2, TGF-ß R3, and connective tissue growth factor (25); several MMPs, including MMP-2 (2), MMP-1, and MMP-13 (4); and TGF-ß3, TßR-II, αSMA, and MMP-3 (16).…”

Section: Introductionmentioning

confidence: 99%

“…Transcriptome profiling tissue studies in dogs with MVD have shown an increase in the transcription of several signalling pathways including cell signalling, inflammation, extracellular matrix, cell defence, immune function, and metabolism (18). Studies on affected tissues have shown up-regulation of MMP-1 and MMP-9 as well as collagen III (25), serotonin receptor 2B (18), MMP-1, MMP-14, and tissue inhibitors of metalloproteinases (TIMPs) such as TIMP-2, TIMP-3, and TIMP-4 (2, 3).…”

Section: Introductionmentioning

confidence: 99%

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Transcriptomic profiling of peripheral blood nucleated cells in dogs with and without clinical signs of chronic mitral valve disease

Garncarz

Hulanicka

Parzeniecka-Jaworska

et al. 2014

Bulletin of the Veterinary Institute in Pulawy

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The aim of the study was to demonstrate differences in the gene expression of signalling pathways between healthy dogs and dogs with chronic mitral valve disease in different heart failure groups. Blood samples were collected from 49 dogs of various breeds between 1.4 and 15.2 years of age. Isolated RNA samples were analysed for quality and integrity and the gene expression profile was determined. The study demonstrated that nucleated cells from peripheral blood can be used to assess the status of heart failure in dogs. Furthermore, significant differences in the expression of the genes were noticed between healthy dogs and dogs with clinical signs of chronic mitral valve disease. This is a preliminary non-invasive study showing the feasibility of genetic testing from peripheral blood nucleated cells, which at the same time has made it possible to set the future directions of genetic studies in clinical cases of canine chronic mitral valve disease.

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Pathophysiology of Aortic Stenosis and Mitral Regurgitation

Perrucci

Zanobini

Gripari

et al. 2017

Comprehensive Physiology

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The global impact of the spectrum of valve diseases is a crucial, fast-growing, and underrecognized health problem. The most prevalent valve diseases, requiring surgical intervention, are represented by calcific and degenerative processes occurring in heart valves, in particular, aortic and mitral valve. Due to the increasing elderly population, these pathologies will gain weight in the global health burden. The two most common valve diseases are aortic valve stenosis (AVS) and mitral valve regurgitation (MR). AVS is the most commonly encountered valve disease nowadays and affects almost 5% of elderly population. In particular, AVS poses a great challenge due to the multiple comorbidities and frailty of this patient subset. MR is also a common valve pathology and has an estimated prevalence of 3% in the general population, affecting more than 176 million people worldwide. This review will focus on pathophysiological changes in both these valve diseases, starting from the description of the anatomical aspects of normal valve, highlighting all the main cellular and molecular features involved in the pathological progression and cardiac consequences. This review also evaluates the main approaches in clinical management of these valve diseases, taking into account of the main published clinical guidelines. © 2017 American Physiological Society. Compr Physiol 7:799-818, 2017.

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Genomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease

Abstract: Evaluation of global expression patterns provides a molecular portrait of mitral valve disease, yields insight into the pathophysiologic aspects of DMVD, and identifies intriguing genes and pathways for further study.

Cited by 78 publications

References 44 publications

Serum serotonin concentration in lean and obese dogs with myxomatous mitral valve disease

Serum serotonin concentration in lean and obese dogs with myxomatous mitral valve disease

Transcriptomic profiling of peripheral blood nucleated cells in dogs with and without clinical signs of chronic mitral valve disease

Pathophysiology of Aortic Stenosis and Mitral Regurgitation

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