Inhibitory effects of the ethanol extract of Gleditsia sinensis thorns on human colon cancer HCT116 cells in vitro and in vivo

Lee, Se-Jung; Cho, Younghwa; Kim, Heejong; Park, Keerang; Park, Sung-Kyu; Ha, Sandie; Kim, Wun-Jae; Moon, Sung‐Kwon

doi:10.3892/or_00000594

Cited by 13 publications

(4 citation statements)

References 29 publications

(47 reference statements)

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“…Dai et al [24] demonstrated that the ethanolic extract from the anomalous fruits of Gleditsia sinensis possesses antiallergic and anti-inflammatory activities, which may mediated by decreasing the release of mediators like histamine from mast cells and also weakening the inflammatory action of all these mediators. Hou et al [25] stated that the saponin fraction from anomalous fruits of Gleditsia sinensis Lam. (SFGS) should be a candidate important therapeutic agent for rheumatoid arthritis.…”

Section: Problem Statement and Analysis Of The Recent Researches And Publicationsmentioning

confidence: 99%

“…(Caryophyllaceae) has a remarkable anti-CPID effect, probably due to inhibition of the inflammation reaction by the promotion, and the induction of the apoptosis of inflammatory cells and down regulation of the serum levels of inflammation cytokines. Lee et al [38] recognized a novel molecular mechanism for the ethanol extract of Gleditsia sinensis thorns (EEGS) in the treatment of colon cancer and might provide a theoretical basis for the possible therapeutic use of EEGS in malignancies treatment. Tong et al [39] indicated that Gleditsioside B (GB), a triterpene saponin isolated from the anomalous fruits of Gleditsia sinensis Lam.…”

Section: Problem Statement and Analysis Of The Recent Researches And Publicationsmentioning

confidence: 99%

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Study of Chinese Honey Locust (Gleditsia Sinensis) and Shallot (Allium Ascalonicum L.) for Integrate Traditional Chinese Medicine Into Other Countries' Medicine in Order to Improve Public Health

Shahrajabian

Sun

Khoshkharam

et al. 2020

LPPU

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The population health is an important component of the country development, since the working capacity and workers' safety in the workplace depends on their health status. Toxic substances that are used the manufacturing process often cause allergies, inflammatory processes of the skin and internal organs, sometimes diabetes and cancer. To strengthen immunity and improve the health of workers, traditional Chinese medicine, which has achieved great success at present, can be recommended. The aim of this manuscript is review of health benefits and pharmaceutical impacts of Chinese honey locust and shallot. Literature search was conducted in Medline, Research Gate, Scopus, PubMed and Google Scholar Databases. The keywords were Chinese honeylocust, shallot, traditional Chinese medicine, Asian medicine and modern pharmaceutical Sciences. Gleditsia sinensis Lam. (G. sinensis) is a perennial arbour spread in most parts of the world, especially in China. It is a classical traditional Chinese medical herb. All relevant papers in the English language of researchers from different countries were collected. The most important benefits of shallots are high source of antioxidants, improve heart health, cancer prevention, and diabetes, anti-inflammatory, antimicrobial, might help fight obesity, and help to prevent or treat allergies. The most important components of Gleditsia sinensis are triterpenoid saponins, triterpenes, flavonoids, alkaloids, phenolics, sterols, and their important derivatives are responsible for tremendous medicinal effects. It has been reported that Gleditsia sinensis Lam thorn (GST) possesses a wide spectrum of pharmacological activities such as antioxidant, anti-inflammatory, anti-microbial, anti-angiogenic and anti-tumor effects. Its fruit is antibacterial, antifungal, antitussive, astringent, emetic, expectorant, haemostatic and stimulant. The seed is emetic, expectorant, decongestant and purgative, and its root bark is both anthelmintic and antifebrile. The obtained findings suggest potential of Shallot and Chinese honey locust in both food and pharmaceutical industries. The demand for shallot products is increasing every year with increase population growth and food industries. More clinical studies may necessary to uncover the numerous substances and their effects in shallot that contribute to public health.

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Section: Problem Statement and Analysis Of The Recent Researches And Publicationsmentioning

confidence: 99%

Section: Problem Statement and Analysis Of The Recent Researches And Publicationsmentioning

confidence: 99%

Study of Chinese Honey Locust (Gleditsia Sinensis) and Shallot (Allium Ascalonicum L.) for Integrate Traditional Chinese Medicine Into Other Countries' Medicine in Order to Improve Public Health

Shahrajabian

Sun

Khoshkharam

et al. 2020

LPPU

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Section: Introductionmentioning

confidence: 99%

“…Zao-Jiao-Ci (ZJC), also known as Gleditsia sinensis , is a traditional Chinese medicine with a variety of bioactivities, especially antitumor activity, which has been widely used in clinic [ 5 ]. It was investigated that the ethanol extract of Gleditsia sinensis (EEGS) could suppress the growth of human colon cancer HCT116 cells in vitro and in vivo [ 6 ]. The extract of Gleditsia sinensis fruit performed inhibitory effects on esophageal squamous cell carcinoma (ESCC) cells, breast cancer MCF-7 cells, hepatoblastoma HepG2 cells, and so on [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Zao-Jiao-Ci in the Treatment of LSCC

Xiang¹,

Lin

et al. 2021

Journal of Oncology

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Objective. Zao-Jiao-Ci (ZJC), a traditional Chinese medicine, is considered as a promising candidate to treat laryngeal squamous cell carcinoma (LSCC). However, the underlying molecular mechanism remains unclear. Methods. Gene expression profiles of GSE36668 were available from the GEO database, and differentially expressed genes (DEGs) of LSCC were obtained by R package; subsequently, enrichment analysis on KEGG and GO of DEGs was performed. The active ingredients of ZJC were screened from the TCMSP database, and the matched candidate targets were obtained by PharmMapper. Furthermore, we constructed protein-protein interaction (PPI) networks of DEGs and candidate targets, respectively, and we screened the core network from the merged network through combining the two PPI networks using Cytoscape 3.7.2. The key targets derived from the core network were analyzed to find out the associated KEGG signal enrichment pathway. By the GEPIA online website, Kaplan–Meier analysis was used to complete the overall survival and disease-free survival of the selected genes in the core module. Results. We identified 96 candidate targets of ZJC and 86 DEGs of LSCC, the latter including 50 upregulated genes and 36 downregulated genes. DEGs were obviously enriched in the following biological functions: extracellular structure organization, the extracellular matrix organization, and endodermal cell differentiation. The 60 key targets from the core network were enriched in the signal pathways including transcriptional misregulation cancer, cell cycle, and so on. We found that LSCC patients with high expression of HIST1H3J, HIST1H3F, and ITGA4 had worse overall survival, while higher expression of NTRK1, COPS5, HIST1H3A, and HIST1H3G had significantly worse disease-free survival. Conclusion. It suggested that the interaction between ZJC and LSCC was related to the signal pathways of transcriptional misregulation cancer and cell cycle, revealing that it may be the mechanism of ZJC in the treatment of LSCC.

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Comprehensive profiling of chemical composition of Gleditsiae spina using ultra‐high‐performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry

Bai

Jing

Yang

et al. 2023

Rapid Comm Mass Spectrometry

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RationaleGleditsiae spina (GS) is an important herb used in traditional and folk medicinal systems of East Asian countries for its various medicinal properties. In China, it has been traditionally used through the centuries for its anticancer, detoxication, detumescence, apocenosis, and antiparasitic effects. Although some of its ingredients have been isolated and identified, most active constituents remain unknown. Past research mostly exploited nuclear magnetic resonance for the identification of compounds, which is suitable for monomers only. Moreover, the extraction and isolation procedures for obtaining purified molecules are time consuming. Therefore, establishing an efficient approach will assist in rapid discovery of the potential active ingredients of GS. The present study aimed to identify the chemical constituents in GS by a data analysis strategy using ultra‐high‐performance liquid chromatography combined with quadrupole time‐of‐flight tandem mass spectrometry.MethodsFirst, the theoretical formula of the candidate compound was calculated using the accurate mass of the precursor/adduct ions. Second, the compounds were classified by the diagnostic ions from the MS/MS data. Third, characteristic ion filtering was used to identify the structures. Finally, the diverse skeletons and substitutions were further identified through the neutral loss in the GS.ResultsA total of 277 compounds were identified in GS, comprising 169 flavonoids, 70 lignans, and 38 other compounds. At least 43 potential new compounds were represented.ConclusionsThis experiment devised an efficient and systematic method for detecting complex compounds and provided a foundation for future research into bioactive ingredients and quality control of GS.

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Inhibitory effects of the ethanol extract of Gleditsia sinensis thorns on human colon cancer HCT116 cells in vitro and in vivo

Cited by 13 publications

References 29 publications

Study of Chinese Honey Locust (Gleditsia Sinensis) and Shallot (Allium Ascalonicum L.) for Integrate Traditional Chinese Medicine Into Other Countries' Medicine in Order to Improve Public Health

Study of Chinese Honey Locust (Gleditsia Sinensis) and Shallot (Allium Ascalonicum L.) for Integrate Traditional Chinese Medicine Into Other Countries' Medicine in Order to Improve Public Health

Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Zao-Jiao-Ci in the Treatment of LSCC

Comprehensive profiling of chemical composition of Gleditsiae spina using ultra‐high‐performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry

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