Inhibitory effects of sasanquasaponin on over-expression of ICAM-1 and on enhancement of capillary permeability induced by burns in rats

Huang, Qiren; Shao, Longquan; He, Ming; Chen, Heping; Liú, Dan; Luo, Yongming; Dai, Yucheng

doi:10.1016/j.burns.2005.02.006

Cited by 29 publications

(15 citation statements)

References 27 publications

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“…Moreover, the plasma levels of ICAM-1 shows parallelism with the significance of inflammation in diseases and it is elevated in various diseases such as infectious, inflammatory and neoplastic (Li et al, 1999;Hajilooi et al, 2004;Huang et al;Miller et al, 2007;Fotis et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

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Age-Related Changes in the Expression of ICAM-1 in the Aorta of Wistar Albino Rats

et al. 2016

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KETANI, S.; KARAKOÇ, Z.; KETANI, M. A. & KILINÇ, M.Age-related changes in the expression of ICAM-1 in the aorta of Wistar albino rats. Int. J. Morphol., 34(4):1482Morphol., 34(4): -1486Morphol., 34(4): , 2016. SUMMARY:ICAM-1 which is expressed by endothelial cells and leukocytes are observed as first markers in diseases such as transplant rejection, diabetes and atherosclerosis and in infections caused by various pathogens. In the present study, it is aimed to reveal the age-related changes in the expression of ICAM-1 on rats. Therefore, a total of 30 albino rats were taken at the age of 6, 18 and 24 months without gender discrimination. Rats were fed with standard pellet feed during the study. Afterwards, rats were sacrificed and tissue samples were collected from their rats, and the samples were evaluated under the light microscope by staining with immnunohistochemical method. It was determined that the expression of both aortic endothelial cells and endothelial cells in the media layer had been significantly increased based on the age.

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Section: Discussionmentioning

confidence: 99%

“…Plasma levels of ICAM-1 shows parallelism with the significance of inflammation in diseases. In various diseases such as infectious, inflammatory and neoplastic, an elevation was detected in the serum levels of ICAM-1 (Huang et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Age-Related Changes in the Expression of ICAM-1 in the Aorta of Wistar Albino Rats

et al. 2016

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“…Control effect of saponin against insects, pests and mites has been reported (Kawai et al, 1999). In addition, It is used as a medicine for the treatment of intestinal disorders (Huang et al, 2007) and burn injuries (Huang et al, 2005). Saponin has also been reported to exert many pharmacological effects, including antihyperlipidemic (Yoshikawa et al, 2005), antiallergic (Matsuda et al, 2010), and cardioprotective effects (Liao et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Boran¹,

Ciftci²,

Er³

et al. 2015

Turk. J. Fish. Aquat. Sci.

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In aquaculture, bacterial fish diseases are still one of the most serious problem and fish mortality of bacterial origin can cause significant economic losses worldwide. The evolution of microorganism resistance to antibiotics has resulted in growing need for new antibacterial compounds. In the present study, the antibacterial activity of green tea (Camellia sinensis L.)seed and its secondary metabolite saponin were evaluated on five bacterial fish pathogens that cause diseases in rainbow trout (Oncorhynchus mykiss, Walbaum). In addition to this, possible histological effects were investigated on the vital organs of fish. The antibacterial activity of tea seed and saponin were determined using the agar diffusion method. Watered tea seed (WTS) powder and saponin used in this research as the feed additives demonstrated antibacterial activity against the five pathogens but statistically significant inhibition was observed only with Listonella anguillarum. Accordingly, significantly higher survival levels were observed in fish infected with L. anguillarum in WTS and saponin diet groups. However, organs of fish fed with WTS and saponin showed some nonvital symptoms such as hyperplasia and epithelial lifting in the gills and lipid droplets, intercellular edema and nuclear degeneration in liver. Results from this study confirmed the potential use of WTS as a source of antibacterial compounds or as a feed additive for prevention of disease against L. anguillarum infection in trout culture.Keywords: Tea seed, saponin, antibacterial activity, histopathology, rainbow trout.Yeşil Çay (Camellia sinensis L.) Tohumunun Bazı Balık Patojenlerine Karşı Antibakteriyel Aktivitesinin Gökkuşağı Alabalıklarında (Oncorhynchus mykiss, Walbaum) Değerlendirilmesi ÖzetAkuakültürde bakteriyel balık hastalıkları günümüzde hala en önemli problemlerden bir tanesini oluşturmakta ve bakteriyel kaynaklı balık ölümleri dünya çapında önemli ekonomik kayıplara sebep olabilmektedir. Mikroorganizmalarda antibiyotiklere karşı direnç gelişimi, yeni antibakteriyel bileşiklere olan ihtiyacın artmasına neden olmuştur. Bu çalışmada, yeşil çay (Camellia sinensis L.) tohumu ve onun ikincil bir metaboliti olan saponinin gökkuşağı alabalıklarında (Oncorhynchus mykiss, Walbaum) hastalığa sebep olan beş farklı bakteriyel balık patojeni üzerindeki antibakteriyel aktiviteleri araştırılmıştır. Ayrıca, balıkların hayati organlarına ait dokularda oluşabilecek histopatolojik etkiler incelenmiştir. Çay tohumu ve saponinin antibakteriyel aktivitesi agar difüzyon yöntemi kullanılarak belirlenmiştir. Bu çalışmada yem katkı maddesi olarak kullanılan sulandırılmış çay tohumu (SÇT) tozu ve saponin beş balık patojenine karşı antibakteriyel aktivite göstermiştir, fakat sadece Listonella anguillarum bakterisine karşı istatistiksel olarak önemli derecede bir etki tespit edilmiştir. Benzer şekilde, L. anguillarum ile enfekte edilen balıklarda, SÇT ve saponin diyet gruplarında istatistiksel olarak önemli derecede bir hayatta kalma oranı gözlenmiştir. Bunun yanında, SÇT ve s...

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“…Among them, foliatheasaponins III, I, II, and IV [25] 38 -41, resp., as well as theasaponin B 1 (42) [33] and isotheasaponins B 1 -B 3 (43 -45, resp.) [34] were reported as new saponins.…”

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confidence: 99%

“…), together with jegosaponin B (81), were isolated from the flower buds [20]. From the defatted seed cake, sasanquasaponin (37) [42], theasaponin E 2 methyl ester (82), [43], and a saponin mixture containing 36 [44] were isolated.…”

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confidence: 99%