Inhibitory effects of rosmarinic acid on the proliferation of cultured murine mesangial cells

Makino, Toshiaki; Ono, Takahiko; Muso, Eri; Yoshida, Haruyoshi; Honda, Gisho; Sasayama, Shígetake

doi:10.1093/ndt/15.8.1140

Cited by 65 publications

(37 citation statements)

References 13 publications

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“…In vitro studies revealed that RA inhibits cytokine-induced murine mesangial cell proliferation, suggesting that this substance may be useful in preventing the progression of mesangioproliferative glomerulonephritis. 16) This result was later confirmed by in vivo experiments, using the experimental model of ATS-induced glomerulonephritis in rats. 17) Again, as in other cases, the dimer of caffeic acid showed a much more pronounced effect than monomeric caffeic acid.…”

mentioning

confidence: 75%

“…15,18) In both cases, the active substances have been determined to be polyphenols: RA in the case of P. frutescens and lithospermate B in the case of S. miltiorrhizae. [15][16][17][18] A detailed investigation of the phenolic compounds in E. sericeum callus and root cultures revealed that RA and rabdosiin are the predominant CAMs synthesized by these cultures. 19) Additionally, the cultures contained trace amounts of eritrichin, a new substance identified as a trimer of caffeic acid that most likely represents a rabdosiin biosynthetic precursor.…”

Section: Discussionmentioning

confidence: 99%

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High Rabdosiin and Rosmarinic Acid Production inEritrichium sericeumCallus Cultures and the Effect of the Calli on Masugi-Nephritis in Rats

Inyushkina

Bulgakov

Веселова

et al. 2007

Bioscience, Biotechnology, and Biochemistry

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mentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

High Rabdosiin and Rosmarinic Acid Production inEritrichium sericeumCallus Cultures and the Effect of the Calli on Masugi-Nephritis in Rats

Inyushkina

Bulgakov

Веселова

et al. 2007

Bioscience, Biotechnology, and Biochemistry

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“…The anti-gout, antiinflammatory and antioxidant activity of celery extracts may be due to the presence of phenolic compounds, long chain fatty acids and phytosterols as reported by Mohamed and Al-okbi (2008). Sweet basil contains rosmarinic acid, which possesses anti-inflammatory and antioxidant activities (Makino et al, 2000;Jayasinghe et al, 2003). Sage leaf aqueous and butanol extracts have analgesic and anti-inflammatory effects due to the presence of carnosol and carnosic acid, which are phenolic diterpenes (Qnais et al, 2010;Kim et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the anti-inflammatory and anti-arthritic effects of some plant extracts

Abdel-Moein¹,

Abdel-Moniem²,

Mohamed³

et al. 2011

Grasas y Aceites

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365plant extracts with different degrees ranging from 47 to 62%. The methanol extract of celery, sage and eucalyptus showed improvement in the level of plasma malondialdehyde, tumor necrosis factor-α and uric acid and also showed significant improvements in body weight and total food intake. The methanol extract of celery, sage and eucalyptus showed complete safety for liver and kidney functions. α-Linolenic acid and linoleic acid were present in all the studied plants. Stigmasterol and b-sitosterol were present in all the studied plants. KEY-WORDS:Anti-arthritic -Anti-inflammatory -Celery -Eucalyptus sage -Sweet basil. INTRODUCTIONRheumatoid arthritis (RA) is one of the major human autoimmune diseases affecting about 1 per cent of the adult population (Lipsky, 2005). The disease is characterized by inflammation of the synovial tissue and damage to the cartilage and bone of the joints, leading to severe deformities (Brennan & McInnes, 2008;Gorman & Cope, 2008). The drugs that inhibit inflammatory reactions are a vital component of the therapeutic arsenal against RA (Kremers et al., 2004). However, the adverse reactions and toxicity associated with the use of these drugs have expeditiously promoted the use of natural plant products or procedures belonging to the diverse traditional systems of medicine by patients with RA (Nozaki et al., 2006;Chang et al., 2010) and other chronic inflammatory disorders (Salvioli et al., 2007;Jung et al., 2007;Alleva et al., 2010). This growing trend warrants a continuous search for new natural anti-arthritic products. Adjuvant-induced arthritis (AIA) is a wellestablished model of rheumatoid arthritis that can be induced in rats by an intradermal injection of Freund's adjuvant (Holmdahl et al., 2001). The AIA model reproduces most of the bone changes found in RA (Holmdahl et al., 2001), including inflammatory bone loss, which has been linked to an increased risk of fracture (Joffe & Epstein, 1991). The role of plant products in various diseases has been known RESUMEN Evaluación de los efectos anti-inflamatorio y antiartrítico de algunos extractos de plantasEl objetivo de la presente investigación ha sido estudiar la actividad anti-inflamatoria de flores de albahaca dulces, hojas de eucalipto, hojas de apio y salvia. Se ha estudiado el efecto sobre la inflamación aguda de extractos metanólicos de apio, salvia y eucalipto y sobre la artritis inducida en ratas. Se han evaluado los efectos de los extractos metanólicos de apio, salvia y eucalipto sobre los parámetros bioquímicos determinados en la artritis inducida y su seguridad en las funciones del hígado y el riñón. Se han estudiado los ácidos grasos, hidrocarburos y fitoesteroles de todas las plantas objeto de la investigación. Los resultados han revelado una actividad antiinflamatoria de los extractos de las plantas estudiadas con diferentes grados entre un 47 y un 62%. Los extractos metanólico de apio, de salvia y de eucalipto han mostrado una mejoría de los niveles de malondialdehído en plasma, factor de necrosis tumoral α y de á...

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“…Its use since ancient times in traditional medicine is justiied by its antiseptic [1,2], antirheumatic [3], anti-inlammatory, antispasmodic [4,5], antimicrobial, and anti-hepatotoxic properties [6]. Its appreciation as a spice for seasoning and food preservation [7] is supported by a very high antioxidant activity [8].…”

Section: Introductionmentioning

confidence: 99%

Phytochemistry, Antioxidant, Antibacterial Activity, and Medicinal Uses of Aromatic (Medicinal Plant Rosmarinus officinalis)

Hameed¹,

Mohammed²

2017

Aromatic and Medicinal Plants - Back to Nature

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Rosemary is a well-known aromatic and medicinal plant whose consumption serves to remedy the number of disorders. Its essential oil (EO) constitutes an important ingredient for well-being feeling improvement through beauty products such as soaps, perfumes, and deodorants. The identiication of phytochemical compounds is based on the peak area, retention time molecular weight, molecular formula, chemical structure, and pharmacological actions. It contains chemical constitutions, which may be useful for various herbal formulations as anti-inlammatory, analgesic, antipyretic, cardiac tonic, and antiasthmatic. Therefore, this chapter reviews the phytochemical compounds of Rosmarinus oicinalis, using methanolic extraction. The phytochemical compound is screened by gas chromatography-mass spectrometry (GC-MS) method and the evaluation of antimicrobial and antioxidant activities of the essential oils.

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Inhibitory effects of rosmarinic acid on the proliferation of cultured murine mesangial cells

Abstract: Rosmarinic acid inhibits cytokine-induced mesangial cell proliferation and suppresses PDGF and c-myc mRNA expression in PDGF-stimulated mesangial cells. Rosmarinic acid in Labiatae herbs might be a promising agent to prevent mesangial cell proliferation.

Cited by 65 publications

References 13 publications

High Rabdosiin and Rosmarinic Acid Production inEritrichium sericeumCallus Cultures and the Effect of the Calli on Masugi-Nephritis in Rats

High Rabdosiin and Rosmarinic Acid Production inEritrichium sericeumCallus Cultures and the Effect of the Calli on Masugi-Nephritis in Rats

Evaluation of the anti-inflammatory and anti-arthritic effects of some plant extracts

Phytochemistry, Antioxidant, Antibacterial Activity, and Medicinal Uses of Aromatic (Medicinal Plant Rosmarinus officinalis)

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