Inhibitory effects of progestogens on the estrogen stimulation of melanocytes in vitro

Wiedemann, Christine; Nägele, Ursula; Schramm, Georg; Berking, Carola

doi:10.1016/j.contraception.2009.03.005

Cited by 32 publications

(39 citation statements)

References 25 publications

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“…16 However, another study reported that progesterone can inhibit proliferation of human melanocytes. 17 Therefore, the expression of hormone receptors appears to play a critical role in the development of melasma in men, too.…”

Section: Discussionmentioning

confidence: 99%

The histopathological characteristics of male melasma: Comparison with female melasma and lentigo

Jang

Sim

Kang

et al. 2012

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

The histopathological characteristics of male melasma: Comparison with female melasma and lentigo

Jang

Sim

Kang

et al. 2012

Journal of the American Academy of Dermatology

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“…13,14) In order to examine the eŠect of progesterone on the number of pigment cells, exogenous progesterone (1 mg/0.2 ml/mouse/day, i.p.) was given to DBA/2 mice for 13 days.…”

Section: Treatment Of Dba/2 Mice Exposed To Progesterone With Kbymentioning

confidence: 99%

Effects of <i>keishibukuryoganryokayokuinin</i> (gui-zhi-fu-ling-wanliao-jia-yiyiren) on the Epidermal Pigment Cells from DBA/2 Mice Exposed to Ultraviolet B (UVB) and/or Progesterone

Norimoto¹,

Yomoda²,

Fujita³

et al. 2011

YAKUGAKU ZASSHI

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The production of melanin is not only activated by external factors such as sunlight or UV-exposure, but is also considered to be triggered by hormonal factors, particularly sex hormones such as ovarian hormones. Previously, keishibukuryoganryokayokuinin (KBY) was reported to increase the pigmentation and moisture content of dermis in women during the luteal phase of the menstrual cycle, thus suggesting that progesterone could play a critical role in the development of skin pigmentation. In the present study, female DBA/2 mice, a dilute brown strain, were used to examine the effects of KBY on the increase in epidermal pigment cells in mice exposed to ultraviolet B (UVB) radiation or progesterone in an attempt to elucidate its mechanism. An increase in epidermal pigment cells was observed in mice exposed to progesterone. To the best of our knowledge, this is the first study to demonstrate that progesterone causes pigmentation in vivo. Furthermore, administration of KBY to progesterone-exposed mice significantly reduced the number of epidermal pigment cells. However, KBY had no such effects on UVB-induced pigmentation. Another important finding was the gain in body weight in progesterone-exposed mice, while body weight gain was reduced by KBY. The body weight gain was believed to be due to sodium and fluid retention, a kind of adverse effect of progesterone, which may further affect the intracellular pH of melanosomes, which synthesize melanin, in turn, leading to melanin production because tyrosinase activity is linked to the intracellular pH environment. This may help explain the mechanism of the role of KBY in pigmentation.

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“…Beispielsweise reagieren Melanozyten, die Östrogenrezeptoren im Zytosol und im Zellkern besitzen [12], auf β-Ös-tradiol dosisabhängig mit erhöhter Tyrosinase-Aktivität -ein Effekt, der die erhöhte Wahrscheinlichkeit des Auftretens von Melasma in der Schwangerschaft und bei Einnahme von östrogenhaltigen Kontrazeptiva erklären könnte [15]. Neuere Untersuchungen weisen darauf hin, dass der jeweilige Gestagenanteil in oralen Kontrazeptiva entscheidend sein könnte, ob die pigmentierungsfördernden Eigenschaften des Östrogens zum Tragen kommen oder ihnen gegengesteuert wird [26]. …”

Section: > Uv-strahlung Führt Zu Einer Raschen Erhöhung Der Expressiounclassified

Grundlagen der Hautpigmentierung

Brenner

Berking

2010

Hautarzt

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Skin pigmentation is highly determined by genetic factors and so far more than 150 genes have been identified that affect skin color either directly or indirectly. The production of eu- and pheomelanin in melanosomes results from the complex interaction between melanogenic regulators in melanocytes and factors derived from keratinocytes and fibroblasts. Besides genetic determination, pigmentation depends on environmental and endocrine factors that modulate the amount, type and distribution of melanins in the skin. Understanding the intrinsic mechanisms of melanogenesis is the basis for modifications of skin pigmentation which are of great interest pharmaceutically and cosmeceutically.

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Inhibitory effects of progestogens on the estrogen stimulation of melanocytes in vitro

Cited by 32 publications

References 25 publications

The histopathological characteristics of male melasma: Comparison with female melasma and lentigo

The histopathological characteristics of male melasma: Comparison with female melasma and lentigo

Effects of <i>keishibukuryoganryokayokuinin</i> (gui-zhi-fu-ling-wanliao-jia-yiyiren) on the Epidermal Pigment Cells from DBA/2 Mice Exposed to Ultraviolet B (UVB) and/or Progesterone

Grundlagen der Hautpigmentierung

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