Inhibitory Effects of Prior Low-dose X-ray Irradiation on Carbon Tetrachloride-induced Hepatopathy in Acatalasemic Mice

Abstract

The catalase activities in blood and organs of the acatalasemic (C3H/AnLCs(b)Cs(b)) mouse of C3H strain are lower than those of the normal (C3H/AnLCs (a)Cs(a)) mouse. We examined the effects of prior low-dose (0.5 Gy) X-ray irradiation, which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in the acatalasemic or normal mice. The acatalasemic mice showed a significantly lower catalase activity and a significantly higher glutathione peroxidase activity compared with those in the normal mice. Moreover, low-dose irradiation increased the catalase activity in the acatalasemic mouse liver to a level similar to that of the normal mouse liver. Pathological examinations and analyses of blood glutamic oxaloacetic and glutamic pyruvic transaminase activity and lipid peroxide levels showed that carbon tetrachloride induced hepatopathy was inhibited by low-dose irradiation. These findings may indicate that the free radical reaction induced by the lack of catalase and the administration of carbon tetrachloride is more properly neutralized by high glutathione peroxidase activity and low-dose irradiation in the acatalasemic mouse liver.

Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage

“…These results were consistent with the results in our previous reports [17,18]. Taken together, these findings suggest that radon inhalation has a similar biological effect to that of low-dose X-irradiation.…”

“…These findings indicate that the free radical accumulation induced by the lack of catalase and the administration of CCl 4 is more completely neutralized by high GPx activity and low-dose irradiation in acatalasemic mice [17]. We also reported that the effects of post-treatment with low-dose (0.5 Gy) X-irradiation reduced the oxidative damage associated with CCl 4 -induced hepatopathy in acatalasemic mice.…”

“…We also reported that the effects of post-treatment with low-dose (0.5 Gy) X-irradiation reduced the oxidative damage associated with CCl 4 -induced hepatopathy in acatalasemic mice. These findings suggest that low-dose irradiation after CCl 4 administration accelerates the rate of recovery and that catalase plays an important role in the recovery from hepatopathy induced by CCl 4 [18].…”

“…Low-dose X-or γ-irradiation activate antioxidative functions in some organs and inhibit oxidative injury [17][18][19][20][21][22]. We have reported that pretreatment with low-dose X-irradiation inhibited CCl 4 -induced hepatopathy in mice with a catalase deficiency (acatalasemic mice).…”

Protective Effects of Radon Inhalation on Carrageenan-Induced Inflammatory Paw Edema in Mice

“…Low-dose X-or γ-irradiation activates antioxidative functions in some organs and, consequently, inhibits oxidative injury [8][9][10][11][12][13]. In mice for example, pretreatment with low-dose X-irradiation inhibits carbon tetrachloride (CCl 4 )-induced hepatopathy [8] and treatment with low-dose (0.5 Gy) X-irradiation following exposure to CCl 4 reduced the oxidative damage associated with CCl 4 -induced hepatopathy. [9].…”