Inhibitory effects of phthalimide derivatives on the activity of the hepatic cytochrome P450 monooxygenases CYP2C9 and CYP2C19

Flexible End2End Workflow Automation of Hit-Discovery Research

“…The PCS that is used (in-house development [10]) for controlling the automated workflow on the automation island does not offer external access opportunities. Therefore, we go back to a manual initiation of this subprocess.…”

“…The process path specified in the following with the syntheses of compounds and the biological primary screening with an enzyme-based assay is highlighted in this figure. The chosen bioscreening application is an example for other automated tests against further targets [8][9][10]. The results can be generalized.…”

“…For the synthesis of the compounds, a fully automated laboratory robot system ( Figure 5) was available, which among other things can The PCS that is used (in-house development [10]) for controlling the automated workflow on the automation island does not offer external access opportunities. Therefore, we go back to a manual initiation of this subprocess.…”

Uranium pollution in South Africa: past research and future needs

“…While such extrapolation of results from animals to humans is successful in many cases, medical history also records cases where this approach failed spectacularly and resulted in enormous human suffering (e.g. the Contergan scandal in Germany) (Hartung 2010, Kolukisaoglu et al, 2010. i sredstva preko koji dolazi do kontakta nazivamo kanalima izloženosti.…”