Inhibitory effects of Morus nigra L. (Moraceae) against local paw edema and mechanical hypernociception induced by Bothrops jararacussu snake venom in mice

Ribeiro, Anita Eugênia Alencar Santos; Soares, Juliana Mikaelly Dias; Silva, Helder Anderson Lima; Wanderley, Carlos Wagner de Souza; Moura, Celuane Alves; Oliveira-Júnior, Raimundo Gonçalves de; Oliveira, Ana Paula de; Rolim, Larissa Araújo; Costa, Emmanoel V.; Almeida, Jackson Roberto Guedes da Silva; Palheta-Junior, Raimundo C.

doi:10.1016/j.biopha.2019.01.011

Cited by 20 publications

(6 citation statements)

References 78 publications

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“…Its roots and bark may have anti-anemic, anti-inflammatory action when associated with arthritis and rheumatism, in addition to anti-hypertensive (Özgen et al, 2009;Hu et al, 2018). Other research also has been shown anti-aging (Hu et al, 2018;), antibacterial, cytotoxic and antioxidant, antidepressant and neuroprotective, anti-inflammatory and antinocepective (Chen et al, 2016;Cruz-Calsavara et al, 2018Ribeiro et al, 2019Lim & Choi, 2019), neuroprotective effect (Kawvised, Wattanathorn & Thukham-Mee 2017) and nutraceutical (Miljkovick et al, 2015).…”

Section: Resultsmentioning

confidence: 98%

What is the impact of research with Morus nigra? – A scientometric study

Brandão

Romano

Paz

et al. 2021

RSD

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Mulberry (Morus spp.) is an evergreen tree belonging to the Moraceae family. The genus Morus has numerous described species, including Morus nigra, an important plant in agriculture and traditional cultures. The objective of this study was to conduct a scientometric research on the species M. nigra. Bibliographic data was been obtained from the Web of Science database considering two times periods. These analyzes showed that research involving M. nigra is concentrated in the areas of nutrition, pharmacology and agronomy science. Eastern countries and Brazil are the largest producers of knowledge about M. nigra. The research has shown different interests in recent decades, showing that the scientific knowledge produced about the species is associated with the objective for which the plant was used throughout history. There is a trend in the growth of publications focused on the potential antioxidant of M. nigra products. The articles had a greater impact factor in the past, however, a significant growth trend in research with M. nigra in the last three years, also suggested by the increase in the number of publications in the period. Understanding the publication standards assist in directing future research as well as in understanding the current panorama of research associated with the species.

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Section: Resultsmentioning

confidence: 98%

What is the impact of research with Morus nigra? – A scientometric study

Brandão

Romano

Paz

et al. 2021

RSD

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“…Nonsteroid anti-inflammatory drugs are usually used to treat inflammatory processes associated with snake bites. Based on the association of various side effects, for example gastric and duodenal ulcer, bleeding and renal failure, Ribeiro et al [ 83 ] evaluated the anti-inflammatory and antinociceptive effects of Morus nigra ethanolic extract, as well as its activity, when incorporated into electrospun fibers and polymeric microparticles, on mouse paw lesions induced by Bothrops jararacussu venom. Treatment with extract-containing fibers and microparticles decreased the edema of paw 2 and 4 h after venom infiltration, respectively, and altered the extract pharmacokinetics in vivo.…”

Section: Polymeric Microparticles In Biological Testsmentioning

confidence: 99%

Microparticles in the Development and Improvement of Pharmaceutical Formulations: An Analysis of In Vitro and In Vivo Studies

Silva

Menezes

Oliveira

et al. 2023

IJMS

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Microparticulate systems such as microparticles, microspheres, microcapsules or any particle in a micrometer scale (usually of 1–1000 µm) are widely used as drug delivery systems, because they offer higher therapeutic and diagnostic performance compared to conventional drug delivery forms. These systems can be manufactured with many raw materials, especially polymers, most of which have been effective in improving the physicochemical properties and biological activities of active compounds. This review will focus on the in vivo and in vitro application in the last decade (2012 to 2022) of different active pharmaceutical ingredients microencapsulated in polymeric or lipid matrices, the main formulation factors (excipients and techniques) and mostly their biological activities, with the aim of introducing and discussing the potential applicability of microparticulate systems in the pharmaceutical field.

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“…Phenolic compounds constitute the predominant group of substances that are responsible for the inhibition of snake venom. Within this group, the subclasses of flavonoids ( 117 – 120 ), hydroxycinnamic acids and derivatives ( 103 , 121 – 125 ); hydroxybenzoic acids ( 81 , 126 – 130 ), tannins ( 109 – 133 ), coumarins ( 103 , 134 ), among others. The second majority group of substances with antivenom activity are terpenes ( 97 , 105 , 106 , 112 , 135 – 139 ), which are followed by alkaloids ( 140 – 146 ), modified glycosides ( 110 , 111 , 147 ), saponins ( 100 , 101 , 103 , 148 ) and polyketides ( 86 , 149 , 150 ).…”

Section: Ethnopharmacology For Snakebite Treatmentmentioning

confidence: 99%

“…Flavonols are among the most studied analogues, especially because they are more recurrent and often isolated in phytochemical approaches. Aglycone quercetin ( 42 ), isolated from Morus nigra (Moraceae) ( 117 ), Phyllanthus klotzschianus (Phyllanthaceae) ( 103 ) and Erythroxylum ovalifolium (Erythroxylaceae) ( 168 ), have been shown to be potent inhibitors of edema, proteolytic activity and lethality induced by the venom of the snakes B. jararacussu , L. muta and B. jararaca , respectively. Compound 42 , of synthetic origin, was also able to inhibit the PLA 2 s activity of D. russelli (IC 50 2 µM) and N. naja venoms (maximum inhibition of 40%) ( 169 ).…”

Section: Plant Products As Antivenom Agentsmentioning

confidence: 99%

Plant-Derived Toxin Inhibitors as Potential Candidates to Complement Antivenom Treatment in Snakebite Envenomations

et al. 2022

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Snakebite envenomations (SBEs) are a neglected medical condition of global importance that mainly affect the tropical and subtropical regions. Clinical manifestations include pain, edema, hemorrhage, tissue necrosis, and neurotoxic signs, and may evolve to functional loss of the affected limb, acute renal and/or respiratory failure, and even death. The standard treatment for snake envenomations is antivenom, which is produced from the hyperimmunization of animals with snake toxins. The inhibition of the effects of SBEs using natural or synthetic compounds has been suggested as a complementary treatment particularly before admission to hospital for antivenom treatment, since these alternative molecules are also able to inhibit toxins. Biodiversity-derived molecules, namely those extracted from medicinal plants, are promising sources of toxin inhibitors that can minimize the deleterious consequences of SBEs. In this review, we systematically synthesize the literature on plant metabolites that can be used as toxin-inhibiting agents, as well as present the potential mechanisms of action of molecules derived from natural sources. These findings aim to further our understanding of the potential of natural products and provide new lead compounds as auxiliary therapies for SBEs.

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Inhibitory effects of Morus nigra L. (Moraceae) against local paw edema and mechanical hypernociception induced by Bothrops jararacussu snake venom in mice

Cited by 20 publications

References 78 publications

What is the impact of research with Morus nigra? – A scientometric study

What is the impact of research with Morus nigra? – A scientometric study

Microparticles in the Development and Improvement of Pharmaceutical Formulations: An Analysis of In Vitro and In Vivo Studies

Plant-Derived Toxin Inhibitors as Potential Candidates to Complement Antivenom Treatment in Snakebite Envenomations

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