Inhibitory Effects of Lyophilized Dropwort Vinegar Powder on Adipocyte Differentiation and Inflammation

박윤희,; 최준혁,; 황기,; 이승욱,; 양선아,; 유미희,

doi:10.5352/jls.2014.24.5.476

Cited by 16 publications

(5 citation statements)

References 25 publications

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“…been reported have effects that include managing constipation [16], diabetes [17,18], obesity [14,19,20,21,22], inflammation [22], hypertension [23], immunity [24], lipid metabolism [19,20], and fatigue [25]. Additionally, many studies have reported that acetic acid, the key component of vinegar and contained, exhibits anti-obesity properties and improves lipid metabolism in animal models [17,19,26,27].…”

mentioning

confidence: 99%

Comparison of Anti-obesity Effects of Spirit Vinegar and Natural Fermented Vinegar Products on the Differentiation of 3T3-L1 Cells and Obese Rats Fed a High-fat Diet

Son¹,

Kim²,

Shin³

et al. 2017

JFNR

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This study aimed to compare the effects of spirit vinegar and four types of natural fermented vinegar products (apple vinegar, brown rice vinegar, lemon vinegar, and balsamic vinegar) on the differentiation of 3T3-L1 cells and obesity in rats fed a high-fat diet (HFD). Vinegar inhibited the accumulation of lipid droplets during the differentiation of 3T3-L1 cells. Body weight gains, visceral fat pad weights, serum leptin and triglyceride levels, and hepatic lipogenic enzyme mRNA levels were significantly decreased in the HF-vinegar administered groups compared with those in the HF group. Furthermore, oral administration of vinegars significantly reduced the occurrence of fatty liver deposits and steatosis, and inhibited the HF diet-induced increase in adipocyte size. The anti-obesity and lipid-lowering effects were slightly greater in the HF-natural fermented vinegar groups than in the HF-spirit vinegar group. Apple vinegar had the strongest anti-obesity effects in 3T3-L1 cells and obese rats compared with the other tested vinegars. These findings indicated that vinegar administration may have potential for improving some obesity-related parameters in 3T3-L1 cells and obese rats.

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confidence: 99%

Comparison of Anti-obesity Effects of Spirit Vinegar and Natural Fermented Vinegar Products on the Differentiation of 3T3-L1 Cells and Obese Rats Fed a High-fat Diet

Son¹,

Kim²,

Shin³

et al. 2017

JFNR

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“…As shown in Figure 3 a, cell viability was higher than 96%, indicating low cytotoxicity in all experimental groups. Similarly, Park et al found that lyophilized dropwort vinegar powder had low cytotoxicity in 3T3-L1 cells [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, Anti-Obesity, and Anti-Aging Activities of Jeju Citrus Blended Vinegar

Yun¹,

Park²,

Kim³

et al. 2021

Foods

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Various types of vinegars have been developed as interest in their health benefits has increased. In this study, we prepared Jeju citrus blended vinegars (CBVs) by mixing premature mandarin vinegar and mandarin vinegar, with mandarin vinegar used as a control. The physicochemical properties of the vinegars, including pH, total acidity, and sugar content was determined. Moreover, antioxidant, anti-obesity, and anti-aging activities of the vinegars were investigated. Physicochemical analysis revealed that the CBVs had a pH similar to that of mandarin vinegar, whereas CBVs with relatively high premature mandarin vinegar content showed higher acidity and lower sugar content (p < 0.05). Moreover, the antioxidant activities and phenol contents of CBVs were significantly higher than those of mandarin vinegar (p < 0.05). Meanwhile, CBVs showed significantly decreased intracellular triglyceride, lipid accumulation, and anti-obesity related gene levels (p < 0.05), thereby highlighting their anti-obesity activity. In addition, CBVs showed anti-aging activity by increasing cell viability and cell lifespan, while decreasing the expression of senescence-related genes under H2O2-induced oxidative stress. Therefore, CBVs may be useful as a functional food with antioxidant, anti-obesity, and anti-aging effects in various food fields.

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“…지방전구세포를 분화시키는 전사인자 및 하위인 자에는 CCAAT/enhancer-binding protein alpha, beta (C/EBPα, β), peroxisome proliferator-activated receptor gamma(PPARγ), sterol-regulatory element binding protein-1c(SREBP-1c), fatty acid synthase(FAS), fatty acid binding protein 4(FABP4)가 존재한다 (Jeong, 2016;Park 등, 2020). C/EBPβ는 분화 초기 단계에 C/EBPα와 PPARγ의 발현을 유도하며, 이후 하위인자 SREBP-1c, FAS, FABP4 발현을 활성화한다 (Ho 등, 2013;Park, 2014;Williams 등, 2020) (William 등, 2002). 이 두 adipokine은 AMPK 활성에 의해 조절되는 것으로 알려져 있다 (Goransson 등, 2023).…”

Section: 서 론unclassified

Anti-Obesity Effect of Aster yomena Extracts through Regulation of AMPK/SIRT1 Signaling

Hwang,

et al. 2024

JKFN

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In this study, the anti-obesity effect of a 50% ethanol extract from Aster yomena (AY), a natural material with various physiological activities, including anti-inflammatory and anti-allergic effects, was investigated in C3H/ 10T1/2 cells. The AY extract (10, 200, or 500 μg/mL) suppressed both the accumulation of lipid droplets, as stained with Oil Red O, and the production of intracellular triglycerides. The extract also suppressed factors related to adipogenesis (CCAAT/enhancer-binding protein alpha, beta, and peroxisome proliferator-activated receptor gamma; PPARγ) and lipogenesis (sterol-regulatory element binding protein-1c, fatty acid synthase, and fatty acid binding protein 4), but it enhanced the expressions of β-oxidation-related mRNA and proteins (AMP-activated protein kinase, acetyl-CoA carboxylase, PPARγ coactivator-1 alpha, and carnitine palmitoyltransferase-1 alpha). In addition, the extract dose-dependently regulated leptin and adiponectin levels. These results suggest the anti-obesity effect of the AY extract is caused by its targeting the above-mentioned adipogenic and β-oxidation factors and that it has potential use for treating obesity.

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Inhibitory Effects of Lyophilized Dropwort Vinegar Powder on Adipocyte Differentiation and Inflammation

Cited by 16 publications

References 25 publications

Comparison of Anti-obesity Effects of Spirit Vinegar and Natural Fermented Vinegar Products on the Differentiation of 3T3-L1 Cells and Obese Rats Fed a High-fat Diet

Comparison of Anti-obesity Effects of Spirit Vinegar and Natural Fermented Vinegar Products on the Differentiation of 3T3-L1 Cells and Obese Rats Fed a High-fat Diet

Antioxidant, Anti-Obesity, and Anti-Aging Activities of Jeju Citrus Blended Vinegar

Anti-Obesity Effect of Aster yomena Extracts through Regulation of AMPK/SIRT1 Signaling

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