Inhibitory effects of different medicinal plants on Candida albicans growth

Abstract

The objective of this study was to evaluate the in vitro antifungal properties of ethanol extracts and essential oils of medicinal plants from Serbia against Candida albicans (C. albicans) ATCC 10231. Ethanol extracts of fifteen plants were investigated, and their effects were compared with those of three different essential oils. The sensitivity of C. albicans to all plants was tested by the agar dilution method. The assay plates were estimated to contain 300, 150, 75, and 37.5 µg/ml of active extracts and 100, 50, 25, and 12.5 µg/ml of active essential oils. Inocula were applied to agar surfaces, giving approximately 106 cfu/ml of C. albicans. No inhibitory effects were observed for ethanol extracts of Hypericum perforatum and Salvia officinalis (MIC > 300 µg/ml). The most effective were the ethanol extract of Aesculus hippocastanum (MIC = 37.5 µg/ml) and the essential oil of Satureja kitaibelii (MIC = 12.5 µg/ml). Other plants showed MIC from 25 to 300 µg/ml. As far as we know, the inhibitory effects of these medicinal plants against the reference strain of C. albicans have not been commonly investigated in our country. Although the essential oil of Satureja kitaibelii shows strong activity against C. albicans, these results need clinical evaluation..

Hypericum Essential Oils—Composition and Bioactivities: An Update (2012–2022)

“…EOs [17,19,20]. Since then, 71 papers have been published describing relevant research work [10,[14][15][16]18,, 34 of them referring to biological activities [20,22,24,32,34,[38][39][40][41][42]46,49,52,54,57,58,60,[62][63][64][65][66][67][68][69][70][71][72]74,77,79,82,83,86] of which antiviral, antimalarial, cytotoxic, neuroprotective, tyrosinase inhibition, immunomodulatory, anti-angiogenic, hepatoprotective, and wound-healing effects had not been tested earlier, thus later data are not described in previous reviews. As a result, we updated the latest information regarding Hypericum EOs' chemical composition and biological activities and we attempted to bridge the potential relationship between traditional uses and Hypericum EOs.…”

Biological Flora of the British Isles:Aesculus hippocastanum

“…Seed extracts also have anti-inflammatory and anti-oedematous properties (Dumitriu, Olariu, Nita, Zglimbe, & Rosoiu, 2013;Matsuda et al, 1997;Sirtori, 2001;Vasiliauskas, Leonavičienė, Vaitkienė, Bradūnaitė, & Lukšienė, 2010;Wilkinson & Brown, 1999) and so have proved effective at clearing skin conditions as an antiwrinkle treatment and in reducing skin ageing (Fujimura et al, 2007;Masaki, Sakaki, Atsumi, & Sakurai, 1995) and may help against cellulite and hair loss (Bellini & Nin, 2005). Extracts of leaves and the bark of young branches have also proved effective as an antioxidant and anti-inflammatory drug (Braga et al, 2012;Margină et al, 2015) and one of the most effective plant extracts in inhibiting Candida albicans (Tambur et al, 2018).…”

Mycostatic Activity of Extracts From Leaves of Plantago Media L. And Plantago Altissima L.

“…About 60 secondary metabolites have been identified during phytochemical studies of Plantago species including phenylethanoid glycosides, triterpenoids, polysaccharides, phenolic acids and other compounds such as alkaloids, caffeic acid derivatives, coumarins, fats and oils, mucilage, polysaccharides, sterols and volatile substances [7,10,[13][14][15]. According to various studies, the antimicrobial and mycostatic effect of plantain extracts is associated with the content of phenolic acids, iridoids, flavonoids and saponins [15][16][17].…”